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27 条记录 (耗时 0.059 秒)

    Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof
    8.
    发明授权
    Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof 失效
    选择性黑色素浓缩激素-1（MCH1）受体拮抗剂及其用途

    公开(公告)号：US06720324B2

    公开(公告)日：2004-04-13

    申请号：US09899635

    申请日：2001-07-05

    申请人： Mohammad R. Marzabadi ,  John Wetzel ,  John E. DeLeon ,  Bharat Lagu ,  Charles Gluchowski ,  Stewart Noble ,  Dhanapalan Nagarathnam

    发明人： Mohammad R. Marzabadi ,  John Wetzel ,  John E. DeLeon ,  Bharat Lagu ,  Charles Gluchowski ,  Stewart Noble ,  Dhanapalan Nagarathnam

    IPC分类号： C07D23932

    CPC分类号： C07D211/58 ,  C07C233/79 ,  C07C2601/14 ,  C07D211/52 ,  C07D295/073 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/06 ,  C07D471/04 ,  C07D471/10 ,  C07D491/04 ,  C07D491/10

    摘要： This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of modifying feeding behavior of a subject which comprises administering to the subject an amount of a compound of the invention effective to decrease the consumption of food by the subject. This invention further provides a method of treating a feeding disorder in a subject which comprises administering to the subject an amount of a compound of the invention effective to decrease the consumption of food by the subject. In an embodiment of the invention, the feeding disorder is bulimia, bulimia nervosa or obesity.

    摘要翻译： 本发明涉及作为黑色素浓缩激素-1（MCH1）受体的选择性拮抗剂的化合物。 本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明提供通过将治疗有效量的本发明化合物与药学上可接受的载体组合而成的药物组合物。 本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供了改变受试者进食行为的方法，其包括向受试者施用量 的有效减少受试者食物消耗的本发明化合物。 本发明进一步提供了治疗受试者进食障碍的方法，其包括向受试者施用一定量的有效降低受试者食物消耗的本发明化合物。 在本发明的一个实施方案中，喂食障碍是贪食症，神经性贪食症或肥胖症。

    Selective NPY (Y5) antagonists (bicyclics)
    9.
    发明授权
    Selective NPY (Y5) antagonists (bicyclics) 有权
    选择性NPY（Y5）拮抗剂（双环）

    公开(公告)号：US06214853B1

    公开(公告)日：2001-04-10

    申请号：US09343633

    申请日：1999-06-30

    申请人： Mohammad R. Marzabadi ,  Wai C. Wong ,  Yasuchika Yamaguchi ,  Stewart A. Noble

    发明人： Mohammad R. Marzabadi ,  Wai C. Wong ,  Yasuchika Yamaguchi ,  Stewart A. Noble

    IPC分类号： A01K31427

    CPC分类号： C07D277/60 ,  C07D277/42 ,  C07D417/12 ,  C07D513/04

    摘要： This invention is directed to bicyclic compounds which are selective antagonists for NPY (Y5) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明涉及作为NPY（Y5）受体的选择性拮抗剂的双环化合物。 本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明提供通过将治疗有效量的本发明化合物与药学上可接受的载体组合而成的药物组合物。 本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。

    Selective NPY (Y5) antagonists
    10.
    发明授权
    Selective NPY (Y5) antagonists 失效
    选择性NPY（Y5）拮抗剂

    公开(公告)号：US07273880B2

    公开(公告)日：2007-09-25

    申请号：US11040328

    申请日：2005-01-20

    申请人： Mohammad R. Marzabadi ,  Wai C. Wong ,  Stewart A. Noble ,  Yasuchika Yamaguchi

    发明人： Mohammad R. Marzabadi ,  Wai C. Wong ,  Stewart A. Noble ,  Yasuchika Yamaguchi

    IPC分类号： A61K31/426

    CPC分类号： C07D277/60 ,  C07D277/42 ,  C07D417/12 ,  C07D513/04

    摘要： This invention is directed to bicyclic and tricyclic compounds which are selective antagonists for NPY (Y5) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of this invention and a pharmaceutically acceptable carrier. The invention provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides the use of a compound of the invention for the preparation of a pharmaceutical composition for treating an abnormality, wherein the abnormality is alleviated by decreasing the activity of a human Y5 receptor.

    摘要翻译： 本发明涉及作为NPY（Y5）受体的选择性拮抗剂的双环和三环化合物。 本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明提供通过将治疗有效量的本发明化合物和药学上可接受的载体组合而制备的药物组合物。 本发明提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。 本发明还提供了本发明化合物用于制备用于治疗异常的药物组合物的用途，其中所述异常通过降低人Y5受体的活性而减轻。