-
公开(公告)号：US09056832B2
公开(公告)日：2015-06-16
申请号：US13821732
申请日：2011-09-16
Applicant: Chiyou Ni , Bin Shao , Laykea Tafesse , Jiangchao Yao , Jianming Yu , Xiaoming Zhou
Inventor： Chiyou Ni , Bin Shao , Laykea Tafesse , Jiangchao Yao , Jianming Yu , Xiaoming Zhou
IPC: C07D401/04 , C07D213/81 , C07D213/30 , C07D401/12 , C07D213/58 , C07D213/643 , C07D401/14 , C07D213/79 , C07D213/74 , A61K31/444 , A61K31/4418 , A61P23/00 , C07D213/46 , C07D213/84 , C07D403/14
CPC classification number: C07D213/81 , C07D213/30 , C07D213/46 , C07D213/50 , C07D213/57 , C07D213/58 , C07D213/643 , C07D213/65 , C07D213/74 , C07D213/79 , C07D213/84 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
Abstract: The invention relates to substituted pyridine compounds of Formula (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, A1, A2, E, G, Z1, and Z2 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
Abstract translation: 本发明涉及式（I）的取代吡啶化合物及其药学上可接受的盐，前体药物和溶剂合物，其中R1a，A1，A2，E，G，Z1和Z2如本说明书所述定义。 本发明还涉及式I化合物用于治疗对钠通道阻断有反应的病症。 本发明的化合物特别适用于治疗疼痛。
-
2.发明授权公开(公告)号：US08791264B2
公开(公告)日：2014-07-29
申请号：US12296799
申请日：2007-04-13
Applicant: Zhengming Chen , Bin Shao , Jiangchao Yao , Xiaoming Zhou
Inventor： Zhengming Chen , Bin Shao , Jiangchao Yao , Xiaoming Zhou
IPC: C07D211/98 , C07D211/58
CPC classification number: C07D211/58
Abstract: The invention relates to piperidinyl and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
Abstract translation: 本发明涉及式（I）的哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂合物，其中R1-R3，Z和q如说明书所述定义。 本发明还涉及使用式（I）化合物来治疗，预防或改善对阻断钙通道，特别是N型钙通道的病症。 本发明的化合物特别适用于治疗疼痛。
-
公开(公告)号：US20090306136A1
公开(公告)日：2009-12-10
申请号：US12296788
申请日：2007-04-13
Applicant: Akira Matsumura , Hidenori Mikamiyama , Bin Shao , Naoki Tsuno , Jiangchao Yao
Inventor： Akira Matsumura , Hidenori Mikamiyama , Bin Shao , Naoki Tsuno , Jiangchao Yao
IPC: A61K31/4468 , G01N33/53 , A61K31/4545 , A61K31/454 , C07D401/06 , C07D211/56 , A61P25/00
CPC classification number: C07D211/58 , A61K31/4468 , A61K31/4545
Abstract: The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z, p and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
Abstract translation: 本发明涉及式（I）的氮杂环丁烷基，吡咯烷基，哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂化物，其中R1-R3，Z，p和q如说明书所述定义。 本发明还涉及使用式（I）化合物来治疗，预防或改善对阻断钙通道，特别是N型钙通道的病症。 本发明的化合物特别适用于治疗疼痛。
-
公开(公告)号：US08846929B2
公开(公告)日：2014-09-30
申请号：US12712042
申请日：2010-02-24
Applicant: Kouki Fuchino , R. Richard Goehring , Bin Shao , Yoshiyuki Taoda , Naoki Tsuno , John William Frank Whitehead , Jiangchao Yao
Inventor： Kouki Fuchino , R. Richard Goehring , Bin Shao , Yoshiyuki Taoda , Naoki Tsuno , John William Frank Whitehead , Jiangchao Yao
IPC: C07D295/00
CPC classification number: C07D451/14 , A61K31/498 , C07D401/04 , C07D401/14 , C07D451/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D498/08 , C07D519/00
Abstract: The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound.
Abstract translation: 本发明涉及取代的喹喔啉型哌啶化合物，包含有效量的取代的喹喔啉型哌啶化合物的组合物和治疗或预防诸如疼痛的病症的方法，包括向有需要的动物施用有效量 的取代的喹喔啉型哌啶化合物。
-
公开(公告)号：US08765736B2
公开(公告)日：2014-07-01
申请号：US12599608
申请日：2008-09-26
Applicant: Bin Shao , Jiangchao Yao
Inventor： Bin Shao , Jiangchao Yao
CPC classification number: C07D211/58 , C07D401/04
Abstract: The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1, R2, R3, Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
Abstract translation: 本发明涉及式（I）的氮杂环丁烷基，吡咯烷基，哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂化物，其中R1，R2，R3，Z和q如说明书所述定义。 本发明还涉及使用式I化合物来治疗对阻断钙通道，特别是N型钙通道有响应的病症。 本发明的化合物特别适用于治疗疼痛。
-
Patent Agency Ranking
公开(公告)号：US20140005212A1
公开(公告)日：2014-01-02
申请号：US13996082
申请日：2011-12-21
Applicant: Chiyou Ni , Minnie Park , Bin Shao , Laykea Tafesse , Jiangchao Yao , Mark Youngman , Xiaoming Zhou
Inventor： Chiyou Ni , Minnie Park , Bin Shao , Laykea Tafesse , Jiangchao Yao , Mark Youngman , Xiaoming Zhou
IPC: C07D213/75 , C07D413/12 , C07D401/12 , C07D401/14 , C07D213/81 , C07D213/76
CPC classification number: C07D213/75 , C07D213/76 , C07D213/81 , C07D401/02 , C07D401/12 , C07D401/14 , C07D413/12
Abstract: The invention relates to substituted pyridine compounds of Formula I: (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, R1b, R2a, R2b, R2c, A1, A2, and X are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
Abstract translation: 本发明涉及式I的取代的吡啶化合物：（I）及其药学上可接受的盐，前药和溶剂化物，其中R1a，R1b，R2a，R2b，R2c，A1，A2和X定义如 规范。 本发明还涉及式I化合物用于治疗对钠通道阻断有反应的病症。 本发明的化合物特别适用于治疗疼痛。
-
公开(公告)号：US20090239910A1
公开(公告)日：2009-09-24
申请号：US12225743
申请日：2007-03-29
Applicant: Zhengning Chen , Khondaker Islam , Bin Shao , Jiangchao Yao , Xiaoming Zhou , Donald J. Kyle
Inventor： Zhengning Chen , Khondaker Islam , Bin Shao , Jiangchao Yao , Xiaoming Zhou , Donald J. Kyle
IPC: A61K31/445 , C07D207/14 , C07D211/56 , A61K31/40 , A61P25/18 , A61P25/28 , A61P25/08 , A61P25/06 , A61P25/22 , A61P25/24 , A61P29/00 , A61P9/12 , A61P9/06
CPC classification number: C07D211/42 , C07D207/14 , C07D401/12
Abstract: The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula I and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
Abstract translation: 本发明涉及式I的氮杂环丁烷基，吡咯烷基，哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂合物，其中R1-R3和Z如说明书所述定义。 本发明还涉及使用式I的化合物来治疗，预防或改善对阻断钙通道，特别是N型钙通道有响应的病症。 本发明的化合物特别适用于治疗疼痛。
-
公开(公告)号：US08247442B2
公开(公告)日：2012-08-21
申请号：US12225743
申请日：2007-03-29
Applicant: Zhengming Chen , Khondaker Islam , Bin Shao , Jiangchao Yao , Donald J. Kyle
Inventor： Zhengming Chen , Khondaker Islam , Bin Shao , Jiangchao Yao , Donald J. Kyle
IPC: A61K31/40 , C07D207/14
CPC classification number: C07D211/42 , C07D207/14 , C07D401/12
Abstract: The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula I and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
Abstract translation: 本发明涉及式I的氮杂环丁烷基，吡咯烷基，哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂合物，其中R1-R3和Z如说明书所述定义。 本发明还涉及使用式I的化合物来治疗，预防或改善对阻断钙通道，特别是N型钙通道有响应的病症。 本发明的化合物特别适用于治疗疼痛。
-
公开(公告)号：US20090291947A1
公开(公告)日：2009-11-26
申请号：US12350450
申请日：2009-01-08
Applicant: Bin Shao , Jiangchao Yao
Inventor： Bin Shao , Jiangchao Yao
IPC: A61K31/535 , C07D265/36 , A61P3/10
CPC classification number: C07D409/12 , C07D207/48 , C07D403/12 , C07D409/14
Abstract: The present invention relates to Proline Analog Compounds that are ligands for cannabinoid receptors, compositions comprising a Proline Analog Compound and a pharmaceutically-acceptable carrier, methods of making such Proline Analog Compounds, and methods for treating or preventing a Condition comprising administering an effective amount of a Proline Analog Compound to an animal in need thereof.
Abstract translation: 本发明涉及作为大麻素受体配体的脯氨酸类似物化合物，包含脯氨酸类似物化合物和药学上可接受的载体的组合物，制备此类脯氨酸类似物的方法，以及用于治疗或预防病症的方法，包括给予有效量的 脯氨酸类似物化合物给有需要的动物。
-
公开(公告)号：US09656959B2
公开(公告)日：2017-05-23
申请号：US13996082
申请日：2011-12-21
Applicant: Chiyou Ni , Minnie Park , Bin Shao , Laykea Tafesse , Jiangchao Yao , Mark A. Youngman , Xiaoming Zhou
Inventor： Chiyou Ni , Minnie Park , Bin Shao , Laykea Tafesse , Jiangchao Yao , Mark A. Youngman , Xiaoming Zhou
IPC: C07D213/75 , C07D401/02 , C07D401/12 , C07D401/14 , C07D213/76 , C07D213/81 , C07D413/12
CPC classification number: C07D213/75 , C07D213/76 , C07D213/81 , C07D401/02 , C07D401/12 , C07D401/14 , C07D413/12
Abstract: The invention relates to substituted pyridine compounds of Formula I: (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, R1b, R2a, R2b, R2c, A1, A2, and X are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
-
-
-
-
-
-
-
-
-
Search Results
61
records
(took 0.029 seconds)
