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    Benzenesulfonamide compounds and their use as blockers of calcium channels
    6.
    发明授权
    Benzenesulfonamide compounds and their use as blockers of calcium channels 有权
    苯磺酰胺化合物及其作为钙通道阻断剂的用途

    公开(公告)号：US08791264B2

    公开(公告)日：2014-07-29

    申请号：US12296799

    申请日：2007-04-13

    申请人： Zhengming Chen ,  Bin Shao ,  Jiangchao Yao ,  Xiaoming Zhou

    发明人： Zhengming Chen ,  Bin Shao ,  Jiangchao Yao ,  Xiaoming Zhou

    IPC分类号： C07D211/98 ,  C07D211/58

    CPC分类号： C07D211/58

    摘要： The invention relates to piperidinyl and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

    摘要翻译： 本发明涉及式（I）的哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂合物，其中R1-R3，Z和q如说明书所述定义。 本发明还涉及使用式（I）化合物来治疗，预防或改善对阻断钙通道，特别是N型钙通道的病症。 本发明的化合物特别适用于治疗疼痛。

    THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN
    10.
    发明申请
    THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 审中-公开
    治疗药物有用的治疗药物

    公开(公告)号：US20110281885A1

    公开(公告)日：2011-11-17

    申请号：US12879885

    申请日：2010-09-10

    申请人： Donald J. Kyle ,  Qun Sun ,  Laykea Tafesse ,  Chongwu Zhang ,  Xiaoming Zhou

    发明人： Donald J. Kyle ,  Qun Sun ,  Laykea Tafesse ,  Chongwu Zhang ,  Xiaoming Zhou

    IPC分类号： A61K31/496 ,  A61K31/497 ,  C12N5/07 ,  C07D417/04 ,  C07D401/04 ,  A61P25/00

    CPC分类号： C07D213/74 ,  C07D213/85 ,  C07D237/20 ,  C07D239/42 ,  C07D241/20 ,  C07D285/06 ,  C07D333/16

    摘要： A compound of formula: wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Cyanoiminopiperazine Compound are disclosed.

    摘要翻译： 本文公开的其中A，Ar，R 3，R 6和m的化合物或其药学上可接受的盐（“氰基亚氨基哌嗪化合物”），包含有效量的氰基亚氨基哌嗪化合物的组合物，以及治疗或预防的方法 疼痛，尿失禁，溃疡，炎性肠病，肠易激综合征，成瘾性疾病，帕金森病，帕金森综合征，焦虑症，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷， 限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的氰基亚氨基哌嗪化合物。