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公开(公告)号：US20050250713A1
公开(公告)日：2005-11-10
申请号：US11114502
申请日：2005-04-26
申请人： Bin Zhu , Brett Marinelli , Mark Macielag
发明人： Bin Zhu , Brett Marinelli , Mark Macielag
IPC分类号： A61K31/7048 , C07H17/00 , C07H17/08
CPC分类号： C07H17/08
摘要： The present invention is directed to novel macrolide antibacterial agents and processes for preparing them. The present invention is further directed to pharmaceutical compositions containing the novel macrolide antibacterial agents disclosed herein and their use in the treatment and prevention of bacterial infections.
摘要翻译： 本发明涉及新型大环内酯类抗菌剂及其制备方法。 本发明进一步涉及含有本文所公开的新型大环内酯抗菌剂及其在治疗和预防细菌感染中的用途的药物组合物。
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2.发明申请公开(公告)号：US20090264450A1
公开(公告)日：2009-10-22
申请号：US12426661
申请日：2009-04-20
申请人： Hugh Alfred Burgoon , Nicole Cathleen Goodwin , Bryce Alden Harrison , Jason Patrick Healy , Ying Liu , Ross Mabon , Brett Marinelli , David Brent Rawlins , Dennis Stewart Rice , Norris Andrew Whitlock
发明人： Hugh Alfred Burgoon , Nicole Cathleen Goodwin , Bryce Alden Harrison , Jason Patrick Healy , Ying Liu , Ross Mabon , Brett Marinelli , David Brent Rawlins , Dennis Stewart Rice , Norris Andrew Whitlock
IPC分类号： A61K31/519 , C07D487/04 , A61P27/02
CPC分类号： C07D487/04
摘要： Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use. Particular compounds are of the formula:
摘要翻译： 公开了LIM激酶2的抑制剂，以及包含它们的药物组合物及其使用方法。 具体化合物具有下式：
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3.发明授权公开(公告)号：US08450332B2
公开(公告)日：2013-05-28
申请号：US13486122
申请日：2012-06-01
申请人： Hugh Alfred Burgoon , Nicole Cathleen Goodwin , Bryce Alden Harrison , Jason Patrick Healy , Ying Liu , Ross Mabon , Brett Marinelli , David Brent Rawlins , Dennis Stewart Rice , Norris Andrew Whitlock
发明人： Hugh Alfred Burgoon , Nicole Cathleen Goodwin , Bryce Alden Harrison , Jason Patrick Healy , Ying Liu , Ross Mabon , Brett Marinelli , David Brent Rawlins , Dennis Stewart Rice , Norris Andrew Whitlock
IPC分类号： A01N43/60 , A61K31/519
CPC分类号： C07D487/04
摘要： Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use. Particular compounds are of the formula:
摘要翻译： 公开了LIM激酶2的抑制剂，以及包含它们的药物组合物及其使用方法。 具体化合物具有下式：
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公开(公告)号：US20120157484A1
公开(公告)日：2012-06-21
申请号：US13290261
申请日：2011-11-07
申请人： Arokiasamy DEVASAGAYARAJ , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
发明人： Arokiasamy DEVASAGAYARAJ , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC分类号： A61K31/505 , A61P1/00 , C07D401/04 , A61K31/506 , C07D239/47 , C07D239/42
CPC分类号： C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要： Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译： 公开了式I和II的化合物，以及包含它们的组合物及其用于治疗，预防和控制5-羟色胺介导的疾病和障碍的方法：
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公开(公告)号：US08063057B2
公开(公告)日：2011-11-22
申请号：US12750278
申请日：2010-03-30
申请人： Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人： Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号： A61K31/505 , C07D239/47 , A61P1/00
CPC分类号： C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要： Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译： 公开了式I和II的化合物，以及包含它们的组合物及其用于治疗，预防和控制5-羟色胺介导的疾病和障碍的方法：
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6.发明授权公开(公告)号：US08193202B2
公开(公告)日：2012-06-05
申请号：US12426661
申请日：2009-04-20
申请人： Hugh Alfred Burgoon , Nicole Cathleen Goodwin , Bryce Alden Harrison , Jason Patrick Healy , Ying Liu , Ross Mabon , Brett Marinelli , David Brent Rawlins , Dennis Stewart Rice , Norris Andrew Whitlock
发明人： Hugh Alfred Burgoon , Nicole Cathleen Goodwin , Bryce Alden Harrison , Jason Patrick Healy , Ying Liu , Ross Mabon , Brett Marinelli , David Brent Rawlins , Dennis Stewart Rice , Norris Andrew Whitlock
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use. Particular compounds are of the formula:
摘要翻译： 公开了LIM激酶2的抑制剂，以及包含它们的药物组合物及其使用方法。 具体化合物具有下式：
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公开(公告)号：US08629156B2
公开(公告)日：2014-01-14
申请号：US13290261
申请日：2011-11-07
申请人： Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
发明人： Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC分类号： C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/18 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12 , A61K31/505 , A61P1/00
CPC分类号： C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要： Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译： 公开了式I和II的化合物，以及包含它们的组合物及其用于治疗，预防和控制5-羟色胺介导的疾病和障碍的方法：
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公开(公告)号：US20100280054A1
公开(公告)日：2010-11-04
申请号：US12750278
申请日：2010-03-30
申请人： Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
发明人： Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC分类号： A61K31/505 , C07D239/47 , A61P1/00
CPC分类号： C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要： Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译： 公开了式I和II的化合物，以及包含它们的组合物及其用于治疗，预防和控制5-羟色胺介导的疾病和障碍的方法：
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公开(公告)号：US07723345B2
公开(公告)日：2010-05-25
申请号：US11638677
申请日：2006-12-12
申请人： Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人： Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要： Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译： 公开了式I和II的化合物，以及包含它们的组合物及其用于治疗，预防和控制5-羟色胺介导的疾病和障碍的方法：
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公开(公告)号：US20100087433A1
公开(公告)日：2010-04-08
申请号：US12571912
申请日：2009-10-01
申请人： Catherine Bomont , Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang
发明人： Catherine Bomont , Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang
IPC分类号： A61K31/5377 , A61K31/4418 , A61K31/444 , A61P25/00
CPC分类号： C07D401/06 , C07D213/74 , C07D213/89 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/14 , C07D417/14
摘要： Compounds, compositions and methods of treating serotonin-mediated diseases and disorders are disclosed.
摘要翻译： 公开了治疗5-羟色胺介导的疾病和病症的化合物，组合物和方法。
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