公开(公告)号：US20220154266A1

公开(公告)日：2022-05-19

申请号：US17665170

申请日：2022-02-04

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yi XUE ,  Joshua RITCHEY ,  Robert MELTZER

IPC: C12Q1/6848 ,  C12Q1/686 ,  C12Q1/6844

Abstract: Emulsion compositions are provided herein. Also provided herein are kits containing one or more emulsion compositions or components for making such emulsion compositions. Also provided herein are methods of using such emulsion compositions, such as for amplification of target nucleic acids in emulsion droplets.

公开(公告)号：US20240076726A1

公开(公告)日：2024-03-07

申请号：US18386975

申请日：2023-11-03

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yi XUE ,  Joshua RITCHEY ,  Robert MELTZER

IPC: C12Q1/6848 ,  C12Q1/6844 ,  C12Q1/686

CPC classification number: C12Q1/6848 ,  C12Q1/6846 ,  C12Q1/686 ,  C12Q1/6816 ,  C12Q2527/125 ,  C12Q2563/159

Abstract: Emulsion compositions are provided herein. Also provided herein are kits containing one or more emulsion compositions or components for making such emulsion compositions. Also provided herein are methods of using such emulsion compositions, such as for amplification of target nucleic acids in emulsion droplets.

公开(公告)号：US20180171133A1

公开(公告)日：2018-06-21

申请号：US15847762

申请日：2017-12-19

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Joshua RITCHEY

IPC: C08L51/00 ,  C08L23/08 ,  B01J19/12

Abstract: Compositions, devices, and methods are disclosed for the covalent modification of polymer surfaces with graft copolymers having a blend of side chains. The halogenated acrylic and polyalkylene glycol acrylic side chains of the graft copolymer provide the polymer surface with high hydrophobicity, as well as increased resistance to biofouling with proteinaceous material. The polymer surfaces can be particularly useful in microfluidic devices and methods that involve the contacting of the covalently modified polymer surfaces with emulsions of aqueous droplets containing biological macromolecules within an oil carrier phase.

公开(公告)号：US20180178213A1

公开(公告)日：2018-06-28

申请号：US15855913

申请日：2017-12-27

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Joshua RITCHEY ,  Yi XUE ,  Robert MELTZER

IPC: B01L3/00

CPC classification number: B01L3/50273 ,  B01L3/502707 ,  B01L3/502784 ,  B01L2200/06 ,  B01L2300/12 ,  B01L2300/165 ,  B01L2400/04 ,  B81C1/00206 ,  C09D183/00 ,  C09D183/04 ,  C12Q1/686 ,  C08K3/36

Abstract: Compositions, devices, and methods are disclosed for the modification of polymer surfaces with coatings having a dispersion of silicone polymer and hydrophobic silica. The surface coatings provide the polymer surface with high hydrophobicity, as well as increased resistance to biofouling with proteinaceous material. The polymer surfaces can be particularly useful in microfluidic devices and methods that involve the contacting of the covalently modified polymer surfaces with emulsions of aqueous droplets containing biological macromolecules within an oil carrier phase.

公开(公告)号：US20240024870A1

公开(公告)日：2024-01-25

申请号：US18229545

申请日：2023-08-02

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Joshua RITCHEY ,  Yi XUE ,  Robert MELTZER

IPC: B01L3/00 ,  C09D183/04 ,  C09D183/00 ,  B81C1/00

CPC classification number: B01L3/50273 ,  C09D183/04 ,  C09D183/00 ,  B81C1/00206 ,  B01L3/502707 ,  B01L3/502784 ,  B01L2300/165 ,  C12Q1/686

Abstract: Compositions, devices, and methods are disclosed for the modification of polymer surfaces with coatings having a dispersion of silicone polymer and hydrophobic silica. The surface coatings provide the polymer surface with high hydrophobicity, as well as increased resistance to biofouling with proteinaceous material. The polymer surfaces can be particularly useful in microfluidic devices and methods that involve the contacting of the covalently modified polymer surfaces with emulsions of aqueous droplets containing biological macromolecules within an oil carrier phase.

公开(公告)号：US20210162406A1

公开(公告)日：2021-06-03

申请号：US17153311

申请日：2021-01-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Joshua RITCHEY ,  Yi XUE ,  Robert MELTZER

IPC: B01L3/00 ,  C09D183/04 ,  C09D183/00 ,  B81C1/00

Abstract: Compositions, devices, and methods are disclosed for the modification of polymer surfaces with coatings having a dispersion of silicone polymer and hydrophobic silica. The surface coatings provide the polymer surface with high hydrophobicity, as well as increased resistance to biofouling with proteinaceous material. The polymer surfaces can be particularly useful in microfluidic devices and methods that involve the contacting of the covalently modified polymer surfaces with emulsions of aqueous droplets containing biological macromolecules within an oil carrier phase.

公开(公告)号：US20200332354A1

公开(公告)日：2020-10-22

申请号：US16921453

申请日：2020-07-06

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yi XUE ,  Joshua RITCHEY ,  Robert MELTZER

IPC: C12Q1/6848 ,  C12Q1/686 ,  C12Q1/6844

Abstract: Emulsion compositions are provided herein. Also provided herein are kits containing one or more emulsion compositions or components for making such emulsion compositions. Also provided herein are methods of using such emulsion compositions, such as for amplification of target nucleic acids in emulsion droplets.

公开(公告)号：US20180216171A1

公开(公告)日：2018-08-02

申请号：US15882098

申请日：2018-01-29

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yi XUE ,  Joshua RITCHEY ,  Robert MELTZER

IPC: C12Q1/6848 ,  C12Q1/686

Abstract: Emulsion compositions are provided herein. Also provided herein are kits containing one or more emulsion compositions or components for making such emulsion compositions. Also provided herein are methods of using such emulsion compositions, such as for amplification of target nucleic acids in emulsion droplets.