公开(公告)号：US20160184813A1

公开(公告)日：2016-06-30

申请号：US15063235

申请日：2016-03-07

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Jiali LIAO ,  Lee OLECH ,  Hong CHEN ,  Xuemei HE ,  Russell FROST

IPC: B01J39/26 ,  C07K1/16

Abstract: Proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of no more than three atoms between the hydrophobic group and the support matrix.

公开(公告)号：US20170232433A1

公开(公告)日：2017-08-17

申请号：US15581569

申请日：2017-04-28

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Jiali LIAO ,  Russell FROST

IPC: B01J41/20 ,  B01J20/22 ,  B01J20/28 ,  B01J20/289 ,  C07K16/00 ,  B01J20/32 ,  B01J41/04 ,  B01J41/09 ,  C07K1/16 ,  B01J20/26 ,  B01J20/288

Abstract: Anion exchange-hydrophobic mixed mode ligands and methods of their use are provided.