公开(公告)号：US20240182601A1

公开(公告)日：2024-06-06

申请号：US18409586

申请日：2024-01-10

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Jiali LIAO ,  Tom BERKELMAN

IPC: C07K19/00 ,  A61K47/69 ,  B01D15/34 ,  B01D15/38 ,  C07K1/16 ,  C07K16/00

CPC classification number: C07K19/00 ,  A61K47/6929 ,  B01D15/34 ,  B01D15/3809 ,  B01D15/3847 ,  C07K1/16 ,  C07K16/00

Abstract: Methods and kits for purifying protein-nanoparticle conjugates are provided. In some embodiments, a multimodal medium having a size exclusion mode and a capture mode is used to purify the protein-nanoparticle conjugates.

公开(公告)号：US20180086850A1

公开(公告)日：2018-03-29

申请号：US15714736

申请日：2017-09-25

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： Jiali LIAO ,  Tom BERKELMAN

IPC: C07K19/00 ,  C07K1/16 ,  C07K16/00 ,  B01D15/34 ,  B01D15/38

CPC classification number: C07K19/00 ,  A61K47/6929 ,  B01D15/34 ,  B01D15/3809 ,  B01D15/3847 ,  C07K1/16 ,  C07K16/00

Abstract: Methods and kits for purifying protein-nanoparticle conjugates are provided. In some embodiments, a multimodal medium having a size exclusion mode and a capture mode is used to purify the protein-nanoparticle conjugates.

公开(公告)号：US20210179736A1

公开(公告)日：2021-06-17

申请号：US17165704

申请日：2021-02-02

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Jiali LIAO ,  Tom BERKELMAN

IPC: C07K19/00 ,  A61K47/69 ,  B01D15/34 ,  B01D15/38 ,  C07K1/16 ,  C07K16/00

Abstract: Methods and kits for purifying protein-nanoparticle conjugates are provided. In some embodiments, a multimodal medium having a size exclusion mode and a capture mode is used to purify the protein-nanoparticle conjugates.

公开(公告)号：US20160184813A1

公开(公告)日：2016-06-30

申请号：US15063235

申请日：2016-03-07

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Jiali LIAO ,  Lee OLECH ,  Hong CHEN ,  Xuemei HE ,  Russell FROST

IPC: B01J39/26 ,  C07K1/16

Abstract: Proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of no more than three atoms between the hydrophobic group and the support matrix.

公开(公告)号：US20230087779A1

公开(公告)日：2023-03-23

申请号：US17800515

申请日：2020-02-19

Applicant: Bio-Rad Laboratories, Inc.

Inventor： James Wei XU ,  Jiali LIAO ,  Christopher BELISLE ,  Fang SONG ,  Haihui YUAN ,  Juan YOU ,  Wenli CAO ,  Xiaozhong BAO

IPC: B01J20/32 ,  B01J20/286 ,  B01J20/30

Abstract: Methods of preparing polymer-filled chromatography resin and their uses are provided.

公开(公告)号：US20170232433A1

公开(公告)日：2017-08-17

申请号：US15581569

申请日：2017-04-28

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Jiali LIAO ,  Russell FROST

IPC: B01J41/20 ,  B01J20/22 ,  B01J20/28 ,  B01J20/289 ,  C07K16/00 ,  B01J20/32 ,  B01J41/04 ,  B01J41/09 ,  C07K1/16 ,  B01J20/26 ,  B01J20/288

Abstract: Anion exchange-hydrophobic mixed mode ligands and methods of their use are provided.