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    METHODS AND COMPOSITIONS FOR CHROMOSOME MAPPING
    1.
    发明申请
    METHODS AND COMPOSITIONS FOR CHROMOSOME MAPPING 审中-公开
    染色体映射的方法和组合

    公开(公告)号：US20160362729A1

    公开(公告)日：2016-12-15

    申请号：US14498352

    申请日：2014-09-26

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： John Frederick Regan ,  Svilen Tzonev

    IPC: C12Q1/68

    CPC classification number: C12Q1/6816 ,  C12Q1/6827 ,  C12Q1/6869 ,  G16C99/00 ,  C12Q2537/143 ,  C12Q2537/165 ,  C12Q2531/113 ,  C12Q2535/122 ,  C12Q2563/107

    Abstract: Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable directional chromosome mapping e.g., using chromosome phasing/haplotyping. The improved methods, compositions, and kits can also enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g., whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.

    Abstract translation: 本文提供了用于分析核酸的改进的方法，组合物和试剂盒。 改进的方法，组合物和试剂盒可以实现定向染色体定位，例如使用染色体定相/单倍型。 改进的方法，组合物和试剂盒还可以使样品中核酸的拷贝数估计。 本文还提供了用于确定样品中靶核酸的两个或多个拷贝（例如，两个或多个拷贝是位于同一染色体或不同染色体上）或用于定相等位基因的连接的方法，组合物和试剂盒。

    AFFINITY-BASED PARTITION ASSAY FOR DETECTION OF TARGET MOLECULES
    3.
    发明申请
    AFFINITY-BASED PARTITION ASSAY FOR DETECTION OF TARGET MOLECULES 有权
    用于检测目标分子的基于AFFINITY的分区测定

    公开(公告)号：US20140228239A1

    公开(公告)日：2014-08-14

    申请号：US14173562

    申请日：2014-02-05

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Adam M. McCoy ,  Svilen Tzonev ,  Frank Hsiung

    IPC: G01N33/566

    CPC classification number: C12Q1/00 ,  G01N33/542 ,  G01N33/581

    Abstract: The present invention provides methods of detecting a target molecule in a sample comprising incubating the sample with two or more detectably labeled probes, partitioning the sample into multiple partitions, and detecting the presence of the two or more probes in the same partition.

    Abstract translation: 本发明提供了检测样品中靶分子的方法，包括用两个或多个可检测标记的探针孵育样品，将样品分成多个分区，以及检测两个或更多个探针在同一分区中的存在。

    METHODS FOR POLYMERASE CHAIN REACTION COPY NUMBER VARIATION ASSAYS
    7.
    发明申请
    METHODS FOR POLYMERASE CHAIN REACTION COPY NUMBER VARIATION ASSAYS 审中-公开
    用于聚合酶链反应的方法复制数变异性测定

    公开(公告)号：US20140162266A1

    公开(公告)日：2014-06-12

    申请号：US14097923

    申请日：2013-12-05

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Niels Klitgord ,  John Regan ,  Svilen Tzonev ,  Eli Hefner ,  Jennifer R. Berman

    IPC: C12Q1/68

    CPC classification number: C12Q1/6851 ,  C12Q2537/16 ,  C12Q2563/159

    Abstract: This disclosure provides methods for measuring the copy number for highly amplified and/or abundant genomic loci. Recognized herein is a need for methods for determining nucleic acid copy number, particularly in instances where one locus to be quantified (i.e., the target) is relatively more abundant than a locus of known abundance (i.e., the reference). In some cases, the method involves combining a query nucleic acid sample with a diluting nucleic acid sample and measuring the relative copy number of a target sequence compared with a reference sequence in the combined sample.

    Abstract translation: 本公开提供了用于测量高度扩增和/或丰富的基因组基因座的拷贝数的方法。 本文认识到需要用于确定核酸拷贝数的方法，特别是在一个待定量的位点（即目标）相对于已知丰度的基因座（即参考文献）相对更丰富的情况下。 在一些情况下，该方法包括将查询核酸样品与稀释的核酸样品组合，并测量与组合样品中的参考序列相比的靶序列的相对拷贝数。

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