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    AFFINITY-BASED PARTITION ASSAY FOR DETECTION OF TARGET MOLECULES
    6.
    发明申请
    AFFINITY-BASED PARTITION ASSAY FOR DETECTION OF TARGET MOLECULES 有权
    用于检测目标分子的基于AFFINITY的分区测定

    公开(公告)号：US20140228239A1

    公开(公告)日：2014-08-14

    申请号：US14173562

    申请日：2014-02-05

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Adam M. McCoy ,  Svilen Tzonev ,  Frank Hsiung

    IPC: G01N33/566

    CPC classification number: C12Q1/00 ,  G01N33/542 ,  G01N33/581

    Abstract: The present invention provides methods of detecting a target molecule in a sample comprising incubating the sample with two or more detectably labeled probes, partitioning the sample into multiple partitions, and detecting the presence of the two or more probes in the same partition.

    Abstract translation: 本发明提供了检测样品中靶分子的方法，包括用两个或多个可检测标记的探针孵育样品，将样品分成多个分区，以及检测两个或更多个探针在同一分区中的存在。

    Digital assays with associated targets
    8.
    发明授权
    Digital assays with associated targets 有权

    公开(公告)号：US09856525B2

    公开(公告)日：2018-01-02

    申请号：US14217357

    申请日：2014-03-17

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Adam M. McCoy ,  Niels Klitgord

    IPC: C12Q1/68

    CPC classification number: C12Q1/6851 ,  C12Q1/6844 ,  C12Q2537/165 ,  C12Q2563/159 ,  C12Q2537/143

    Abstract: System, including methods, apparatus, and compositions, for performing a digital assay with associated targets. In some embodiments, the assay of associated targets in partitions may lower the limit of detection (LOD) or otherwise increase assay sensitivity, accuracy, and/or specificity. The targets may represent spaced or overlapping regions of the same template and/or each may represent a region from a different complementary strand of the same template. In some embodiments, the associated targets may be provided by a type of biological particle, and the target content of partitions may be used to identify and quantify the type of biological particle in a sample.

    DIGITAL ASSAYS WITH ASSOCIATED TARGETS
    10.
    发明申请
    DIGITAL ASSAYS WITH ASSOCIATED TARGETS 有权
    具有相关目标的数字测定

    公开(公告)号：US20140274786A1

    公开(公告)日：2014-09-18

    申请号：US14217357

    申请日：2014-03-17

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Adam M. McCoy ,  Niels Klitgord

    IPC: C12Q1/68 ,  G01N33/53

    CPC classification number: C12Q1/6851 ,  C12Q1/6844 ,  C12Q2537/165 ,  C12Q2563/159 ,  C12Q2537/143

    Abstract: System, including methods, apparatus, and compositions, for performing a digital assay with associated targets. In some embodiments, the assay of associated targets in partitions may lower the limit of detection (LOD) or otherwise increase assay sensitivity, accuracy, and/or specificity. The targets may represent spaced or overlapping regions of the same template and/or each may represent a region from a different complementary strand of the same template. In some embodiments, the associated targets may be provided by a type of biological particle, and the target content of partitions may be used to identify and quantify the type of biological particle in a sample.

    Abstract translation: 用于执行具有相关目标的数字测定的系统，包括方法，装置和组合物。 在一些实施方案中，分区中相关靶标的测定可降低检测限（LOD）或以其它方式增加测定灵敏度，准确性和/或特异性。 靶可以表示相同模板的间隔或重叠区域和/或每个可以表示来自相同模板的不同互补链的区域。 在一些实施方案中，相关联的靶可以由一种生物颗粒提供，并且分隔物的目标含量可用于鉴定和定量样品中生物颗粒的类型。

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