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公开(公告)号：US08999270B2
公开(公告)日：2015-04-07
申请号：US14286271
申请日：2014-05-23
CPC分类号： G01N1/36 , G01N35/00732 , G01N2001/366 , Y10T436/2525 , Y10T436/2575
摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.
摘要翻译： 一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。 该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。 输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。 冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。 安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。 托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。 分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件携带的至少一个组织样本。
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公开(公告)号：US09194779B2
公开(公告)日：2015-11-24
申请号：US14643136
申请日：2015-03-10
CPC分类号： G01N1/36 , G01N35/00732 , G01N2001/366 , Y10T436/2525 , Y10T436/2575
摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.
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公开(公告)号：US20150198509A1
公开(公告)日：2015-07-16
申请号：US14643136
申请日：2015-03-10
IPC分类号： G01N1/36
CPC分类号： G01N1/36 , G01N35/00732 , G01N2001/366 , Y10T436/2525 , Y10T436/2575
摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.
摘要翻译： 一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。 该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。 输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。 冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。 安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。 托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。 分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件携带的至少一个组织样本。
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公开(公告)号：US20140099661A1
公开(公告)日：2014-04-10
申请号：US14105355
申请日：2013-12-13
IPC分类号： G01N1/36
CPC分类号： G01N1/36 , B01L3/508 , B01L9/52 , B01L2300/043 , G01N2001/315 , G01N2001/366 , Y10T436/25
摘要： A method of staging a tissue sample cassette, including a cassette body and a lid, from an upper position in a frame used during a tissue embedding process to a lower position in the frame. The method comprises coupling the cassette with the frame such that the cassette is in the upper position and positively stopped at the upper position by first structure on a wall of the frame. The cassette is moved relative to the frame to the lower position by selectively engaging the cassette with a staging mechanism. An external force is applied to the cassette with the staging mechanism in a direction to move the cassette from the upper position toward the lower position. The cassette is retained in the lower position using second structure on the wall of the frame, such that the cassette is exposed for embedding the cassette in an embedding medium and subsequently slicing the tissue sample embedded in the embedding medium.
摘要翻译： 一种从在组织嵌入过程中使用的框架中的上部位置将组织样本盒（包括盒体和盖子）分层到框架中的下部位置的方法。 该方法包括将盒子与框架连接，使得盒子处于上部位置，并且通过框架壁上的第一结构在上部位置上被主动地停止。 通过选择性地将盒与分段机构接合，盒带相对于框架移动到下部位置。 一个外力作用在盒子上，其中分段机构沿一个使盒子从上部位置向下位置运动的方向。 使用框架壁上的第二结构将盒子保持在下部位置，使得盒子被暴露以将盒子嵌入到嵌入介质中，并随后切片嵌入在嵌入介质中的组织样本。
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5.发明申请公开(公告)号：US20140205515A1
公开(公告)日：2014-07-24
申请号：US14250851
申请日：2014-04-11
IPC分类号： B01L9/00
CPC分类号： B01L9/52 , G01N1/06 , G01N1/312 , G01N1/36 , G01N33/4833 , Y10T436/25
摘要： Tissue orientation devices include a perforated tissue support with at least one perforated channel for receiving a tissue sample, and a plurality of tabs configured to extend along and into the channel to retain the tissue sample during processing and embedding. Tissue orientation devices include elongated legs coupled together for holding one or more biopsy tissue samples therebetween. Associated methods include using the cassettes and orientation devices to hold and orient tissue samples for processing, embedding and microtome sectioning.
摘要翻译： 组织取向装置包括具有至少一个用于接收组织样本的穿孔通道的穿孔组织支撑件，以及多个突出部，其被构造成沿着和延伸通道以在加工和嵌入期间保持组织样本。 组织取向装置包括连接在一起的细长腿以在其间保持一个或多个活检组织样本。 相关方法包括使用盒和取向装置来保持和定向组织样品进行加工，嵌入和切片机切片。
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公开(公告)号：US09097630B2
公开(公告)日：2015-08-04
申请号：US14105355
申请日：2013-12-13
CPC分类号： G01N1/36 , B01L3/508 , B01L9/52 , B01L2300/043 , G01N2001/315 , G01N2001/366 , Y10T436/25
摘要： A method of staging a tissue sample cassette, including a cassette body and a lid, from an upper position in a frame used during a tissue embedding process to a lower position in the frame. The method comprises coupling the cassette with the frame such that the cassette is in the upper position and positively stopped at the upper position by first structure on a wall of the frame. The cassette is moved relative to the frame to the lower position by selectively engaging the cassette with a staging mechanism. An external force is applied to the cassette with the staging mechanism in a direction to move the cassette from the upper position toward the lower position. The cassette is retained in the lower position using second structure on the wall of the frame, such that the cassette is exposed for embedding the cassette in an embedding medium and subsequently slicing the tissue sample embedded in the embedding medium.
摘要翻译： 一种从在组织嵌入过程中使用的框架中的上部位置将组织样本盒（包括盒体和盖子）分层到框架中的下部位置的方法。 该方法包括将盒子与框架连接，使得盒子处于上部位置，并且通过框架壁上的第一结构在上部位置上被主动地停止。 通过选择性地将盒与分段机构接合，盒带相对于框架移动到下部位置。 一个外力作用在盒子上，其中分段机构沿一个使盒子从上部位置向下位置运动的方向。 使用框架壁上的第二结构将盒子保持在下部位置，使得盒子被暴露以将盒子嵌入到嵌入介质中，并随后切片嵌入在嵌入介质中的组织样本。
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7.发明授权Method for orienting tissue samples on a microtome sectionable biopsy support 有权在切片机切片活检支架上定向组织样本的方法公开(公告)号：US08796038B2
公开(公告)日：2014-08-05
申请号：US13678846
申请日：2012-11-16
IPC分类号： G01N1/06 , G01N1/31 , G01N1/36 , G01N33/483
CPC分类号： B01L9/52 , G01N1/06 , G01N1/312 , G01N1/36 , G01N33/4833 , Y10T436/25
摘要： Tissue orientation devices include a perforated tissue support with at least one perforated channel for receiving a tissue sample, and a plurality of tabs configured to extend along and into the channel to retain the tissue sample during processing and embedding. Tissue orientation devices include elongated legs coupled together for holding one or more biopsy tissue samples therebetween. Associated methods include using the cassettes and orientation devices to hold and orient tissue samples for processing, embedding and microtome sectioning.
摘要翻译： 组织取向装置包括具有至少一个用于接收组织样本的穿孔通道的穿孔组织支撑件，以及多个突出部，其被构造成沿着和延伸通道以在加工和嵌入期间保持组织样本。 组织取向装置包括连接在一起的细长腿以在其间保持一个或多个活检组织样本。 相关方法包括使用盒和取向装置来保持和定向组织样品进行加工，嵌入和切片机切片。
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8.发明申请公开(公告)号：US20130078670A1
公开(公告)日：2013-03-28
申请号：US13678846
申请日：2012-11-16
IPC分类号： G01N33/483
CPC分类号： B01L9/52 , G01N1/06 , G01N1/312 , G01N1/36 , G01N33/4833 , Y10T436/25
摘要： Tissue orientation devices include a perforated tissue support with at least one perforated channel for receiving a tissue sample, and a plurality of tabs configured to extend along and into the channel to retain the tissue sample during processing and embedding. Tissue orientation devices include elongated legs coupled together for holding one or more biopsy tissue samples therebetween. Associated methods include using the cassettes and orientation devices to hold and orient tissue samples for processing, embedding and microtome sectioning.
摘要翻译： 组织取向装置包括具有至少一个用于接收组织样本的穿孔通道的穿孔组织支撑件，以及多个突出部，其被构造成沿着和延伸通道以在加工和嵌入期间保持组织样本。 组织取向装置包括连接在一起的细长腿以在其间保持一个或多个活检组织样本。 相关方法包括使用盒和取向装置来保持和定向组织样品进行加工，嵌入和切片机切片。
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