-
公开(公告)号：US20180243376A1
公开(公告)日：2018-08-30
申请号：US15885432
申请日：2018-01-31
发明人： Jeffrey R. Binder , Joel C. Higgins , Michael D. Leach , Krista Toler , Jennifer E. Woodell-May
CPC分类号： A61K38/19 , A61K35/14 , A61K38/1703 , A61K38/1793 , A61K45/06 , A61M1/3693
摘要： Methods for making non-immunogenic anti-inflammatory cytokine compositions, comprising (a) obtaining a liquid comprising cytokine producing cells from a mammalian donor; (b) contacting the liquid with a solid extraction material to generate a composition rich in interleukin-1 receptor antagonist; and performing one or both of (i) removing cells from the composition and (ii) freezing the composition. The compositions comprise two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII. Compositions may also contain white blood cells and platelets.
-
公开(公告)号：US09878011B2
公开(公告)日：2018-01-30
申请号：US13841083
申请日：2013-03-15
IPC分类号： A61K38/00 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/20 , A61K45/06 , A61K35/15 , A61K35/19 , A61K35/28 , A61K35/14
CPC分类号： A61K38/19 , A61K35/14 , A61K35/15 , A61K35/19 , A61K35/28 , A61K38/1703 , A61K38/1793
摘要： Methods and therapeutic compositions for treating respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and devices for administering the therapeutic compositions. Methods for treatment include producing a protein solution, producing a concentrated bone marrow aspirate (cBMA), optionally combining the protein solution and cBMA to form an therapeutic composition, and optionally saturating the autologous therapeutic composition with hydrogen gas, and administering the therapeutic composition to a subject in need thereof. The present methods, compositions and devices are useful for treating COPD and the progression of COPD.
-
公开(公告)号：US20170334960A1
公开(公告)日：2017-11-23
申请号：US15616548
申请日：2017-06-07
CPC分类号： C07K14/47 , A61K9/0019 , A61K38/1709 , A61K45/06 , A61K47/34 , C07K1/34
摘要： Methods and compositions generating and using an interleukin-1 receptor antagonist (IL-1ra)-rich solution. Methods for generating and isolating interleukin-1 receptor antagonist include incubating a liquid volume of white blood cells and platelets with polyacrylamide beads to produce interleukin-1 receptor antagonist. The interleukin-1 receptor antagonist is isolated from the polyacrylamide beads to obtain the solution rich in interleukin-1 receptor antagonist. Methods for treating a site of inflammation in a patient include administering to the site of inflammation the solution rich in interleukin-1 receptor antagonist.
-
公开(公告)号：US20150320938A1
公开(公告)日：2015-11-12
申请号：US14271084
申请日：2014-05-06
CPC分类号： A61M5/31596 , A61B10/025 , A61B10/0283 , A61B2010/0258 , A61M5/3145 , A61M5/31511 , A61M2202/0413 , A61M2202/0443 , A61M2202/062 , A61M2202/09 , A61M2202/10
摘要： A device for processing a biological material is disclosed. The device includes a syringe barrel comprising beads, a filter positioned at a close end of the barrel, a plunger insertable into the barrel through an open end, and a needle. The plunger includes a paddle assembly that is configured to mix a biological material with the beads after the biological material has been harvested from a patient.
摘要翻译： 公开了一种用于处理生物材料的装置。 该装置包括注射器筒，其包括珠，位于筒的近端的过滤器，通过开口端插入到筒中的柱塞和针。 柱塞包括桨组件，其被配置成在从患者收获生物材料之后将生物材料与珠混合。
-
公开(公告)号：US20150273360A1
公开(公告)日：2015-10-01
申请号：US14269655
申请日：2014-05-05
CPC分类号： B01D21/003 , A61M1/029 , A61M1/3693 , A61M1/3695 , B01D17/0217 , B01D21/262 , B01D21/307 , B01D2221/10 , B01L3/50215 , B01L2400/0409 , B01L2400/0633 , G01N33/491
摘要： A material separation system and method is disclosed. The system may include a buoy having a volume that includes or houses a reacting component. The buoy may be placed in a container to hold the material to be separated during a separation procedure. The separated material may be used to various procedures following separation.
摘要翻译： 公开了一种材料分离系统和方法。 系统可以包括具有包括或容纳反应组分的体积的浮标。 浮子可以放置在容器中以在分离过程中保持待分离的材料。 分离的材料可以用于分离后的各种程序。
-
公开(公告)号：US20150147300A1
公开(公告)日：2015-05-28
申请号：US14554381
申请日：2014-11-26
CPC分类号： A61K35/15 , A61K35/16 , C12N5/0645 , C12N5/0667 , C12N2501/20 , C12N2502/1382
摘要： Methods of inducing a polarization of macrophages. The method includes obtaining a blood fraction, fractionating the blood fraction to produce a blood fraction, and contacting the blood fraction with a source of macrophages. A blood fraction including platelet-poor plasma polarizes the source of macrophages into M1 macrophages. A blood faction including a protein solution polarizes the source of macrophages into M2 macrophages.
摘要翻译： 诱导巨噬细胞极化的方法。 该方法包括获得血液分数，分馏血液部分以产生血液部分，并使血液部分与巨噬细胞源接触。 含血小板血浆的血液分数将巨噬细胞源极化为M1巨噬细胞。 包括蛋白质溶液在内的血液系将巨噬细胞的来源极化为M2巨噬细胞。
-
7.发明授权公开(公告)号：US10393728B2
公开(公告)日：2019-08-27
申请号：US15866658
申请日：2018-01-10
IPC分类号： B01L3/00 , B01L9/00 , A61K35/14 , A61K35/17 , A61K35/19 , A61K35/28 , B01D21/26 , B01D21/30 , G01N33/49
摘要： An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
-
公开(公告)号：US10143725B2
公开(公告)日：2018-12-04
申请号：US13837480
申请日：2013-03-15
IPC分类号： A61K38/00 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/20 , A61K35/28 , A61K45/06 , A61K35/14
摘要： Methods for treating pain using a protein solution comprising two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII, Compositions may also contain white blood cells and platelets.
-
公开(公告)号：US09950035B2
公开(公告)日：2018-04-24
申请号：US13840562
申请日：2013-03-15
发明人： Jeffrey R. Binder , Joel C. Higgins , Michael D. Leach , Krista O'Shaughnessey , Jennifer E. Woodell-May
IPC分类号： A61K38/18 , A61K38/16 , C07K14/475 , B01D37/00 , A61K38/19 , A61K38/17 , A61K45/06 , A61M1/36 , A61K35/14
CPC分类号： A61K38/19 , A61K35/14 , A61K38/1703 , A61K38/1793 , A61K45/06 , A61M1/3693
摘要： Methods for making non-immunogenic anti-inflammatory cytokine compositions, comprising (a) obtaining a liquid comprising cytokine producing cells from a mammalian donor; (b) contacting the liquid with a solid extraction material to generate a composition rich in interleukin-1 receptor antagonist; and performing one or both of (i) removing cells from the composition and (ii) freezing the composition. The compositions comprise two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII, Compositions may also contain white blood cells and platelets.
-
10.发明授权公开(公告)号：US09897589B2
公开(公告)日：2018-02-20
申请号：US14510828
申请日：2014-10-09
CPC分类号： G01N33/491 , A61K35/14 , A61K35/17 , A61K35/19 , A61K35/28 , B01D21/262 , B01D21/307 , B01L3/502 , B01L3/5021 , B01L3/50215 , B01L9/54 , B01L2200/026 , B01L2300/0681 , B01L2400/0409 , B01L2400/0478 , B01L2400/0605 , A61K2300/00
摘要： An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.028 秒)
