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    PCV2 immunogenic compositions and methods of producing such compositions
    6.
    发明授权
    PCV2 immunogenic compositions and methods of producing such compositions 有权

    公开(公告)号：US10576142B2

    公开(公告)日：2020-03-03

    申请号：US15886531

    申请日：2018-02-01

    申请人： Boehringer Ingelheim Vetmedica, Inc.

    发明人： Marc Allan Eichmeyer ,  Gregory Paul Nitzel ,  Merrill Lynn Schaeffer

    IPC分类号： A61K39/12 ,  G01N33/569 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

    摘要： An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. The method generally involves the steps of transfecting recombinant virus containing open reading frame 2 coding sequences into cells contained in growth media, causing the virus to express open reading frame 2, and recovering the expressed protein in the supernate. This recovery should take place beginning approximately 5 days after infection of the cells in order to permit sufficient quantities of recombinant protein to be expressed and secreted from the cell into the growth media. Such methods avoid costly and time consuming extraction procedures required to separate and recover the recombinant protein from within the cells.

    USE OF A PCV2 IMMUNOGENIC COMPOSITION FOR LESSENING CLINICAL SYMPTOMS IN PIGS
    7.
    发明申请
    USE OF A PCV2 IMMUNOGENIC COMPOSITION FOR LESSENING CLINICAL SYMPTOMS IN PIGS 审中-公开

    公开(公告)号：US20180236057A1

    公开(公告)日：2018-08-23

    申请号：US15957663

    申请日：2018-04-19

    申请人： Boehringer Ingelheim Vetmedica, Inc.

    发明人： Michael B. Roof ,  Phillip Wayne Hayes ,  Marc Allan Eichmeyer ,  Gregory Paul Nitzel ,  Merrill Lynn Schaeffer

    IPC分类号： A61K39/12 ,  C12N7/00 ,  A61K39/00

    摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.