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公开(公告)号：US08975235B2
公开(公告)日：2015-03-10
申请号：US13585716
申请日：2012-08-14
IPC分类号： C07D495/04 , C07D307/66 , C07D213/75 , C07D413/10 , C07D417/12 , C07D231/40 , C07D401/10 , C07D405/12 , C07D413/04 , C07D249/06 , C07D257/06 , C07D401/04 , A61K31/381 , A61K31/426 , C07D333/20 , A61K31/4192 , A61K31/4427 , A61K31/415 , C07D275/03 , C07D261/14 , A61K31/4155 , C07D471/04 , C07H15/26 , C07D491/04 , A61K31/425 , A61K31/421 , C07D491/048 , C07D277/46 , C07D263/48 , C07D207/34 , A61K31/42
CPC分类号： C07D495/04 , A61K31/381 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/4427 , C07D207/34 , C07D213/75 , C07D231/40 , C07D249/06 , C07D257/06 , C07D261/14 , C07D263/48 , C07D275/03 , C07D277/46 , C07D307/66 , C07D333/20 , C07D401/04 , C07D401/10 , C07D405/12 , C07D413/04 , C07D413/10 , C07D417/12 , C07D471/04 , C07D491/04 , C07D491/048 , C07H15/26
摘要： Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.
摘要翻译： 提供了化合物，制备这种化合物的方法，药物组合物和包含这些化合物的药物，以及使用这些化合物治疗，预防或诊断与一种或多种溶血磷脂酸受体相关的疾病，病症或病症的方法。
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公开(公告)号：US20130072449A1
公开(公告)日：2013-03-21
申请号：US13585716
申请日：2012-08-14
IPC分类号： A61K31/7042 , C07D495/04 , C07D261/14 , C07D417/12 , C07D413/10 , C07D491/048 , C07H15/26 , C07D213/75 , A61K31/519 , C07D487/04 , A61K31/5025 , A61K31/53
CPC分类号： C07D495/04 , A61K31/381 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/4427 , C07D207/34 , C07D213/75 , C07D231/40 , C07D249/06 , C07D257/06 , C07D261/14 , C07D263/48 , C07D275/03 , C07D277/46 , C07D307/66 , C07D333/20 , C07D401/04 , C07D401/10 , C07D405/12 , C07D413/04 , C07D413/10 , C07D417/12 , C07D471/04 , C07D491/04 , C07D491/048 , C07H15/26
摘要： Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.
摘要翻译： 提供了化合物，制备这种化合物的方法，药物组合物和包含这些化合物的药物，以及使用这些化合物治疗，预防或诊断与一种或多种溶血磷脂酸受体相关的疾病，病症或病症的方法。
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公开(公告)号：US06995156B2
公开(公告)日：2006-02-07
申请号：US10947635
申请日：2004-09-22
申请人： Judi A. Bryant , Brad O. Buckman , Imadul Islam , Raju Mohan , Michael M. Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
发明人： Judi A. Bryant , Brad O. Buckman , Imadul Islam , Raju Mohan , Michael M. Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
IPC分类号： A61K31/496 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
CPC分类号： C07D295/205 , C07D215/48 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译： 下式（I）的化合物：化学式id =“CHEM-US-00001”num =“000
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公开(公告)号：US07268140B2
公开(公告)日：2007-09-11
申请号：US11248618
申请日：2005-10-13
申请人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
发明人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
IPC分类号： A61K31/4965 , C07D241/04
CPC分类号： C07D295/185 , C07D215/18 , C07D241/04 , C07D241/38 , C07D261/14 , C07D295/192 , C07D307/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
摘要翻译： 本发明涉及可用作抗炎剂的酰基哌嗪衍生物。 本发明还涉及含有本发明化合物的药物组合物，以及使用该化合物治疗人类炎性疾病的方法。
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公开(公告)号：US06977258B2
公开(公告)日：2005-12-20
申请号：US10347530
申请日：2003-01-17
申请人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
发明人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
IPC分类号： A61K31/4965 , A61K31/497 , A61P29/00 , A61P43/00 , C07D241/04 , C07D261/14 , C07D295/185 , C07D307/52 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/495
CPC分类号： C07D295/185 , C07D215/18 , C07D241/04 , C07D241/38 , C07D261/14 , C07D295/192 , C07D307/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： This invention is directed to acyl piperazine derivatives of formula (Ia): wherein R1a, R2, R3, R4, R5 and R6 are defined herein, which are useful as anti-inflammatory agents. This invention is also directed to other acyl piperazine derivatives, pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
摘要翻译： 本发明涉及式（Ia）的酰基哌嗪衍生物：其中R 1a，R 2，R 3，R 4， 本文定义的R 5和R 6是有用的抗炎剂。 本发明还涉及其它酰基哌嗪衍生物，含有本发明化合物的药物组合物，以及使用该化合物治疗人类炎性疾病的方法。
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公开(公告)号：US06861424B2
公开(公告)日：2005-03-01
申请号：US10163742
申请日：2002-06-05
申请人： Judi A. Bryant , Brad O. Buckman , Imadul Islam , Raju Mohan , Michael M. Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
发明人： Judi A. Bryant , Brad O. Buckman , Imadul Islam , Raju Mohan , Michael M. Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
IPC分类号： C07D295/20 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P7/02 , A61P43/00 , C07D215/48 , C07D215/54 , C07D215/56 , C07D295/205 , C07D307/33 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
CPC分类号： C07D295/205 , C07D215/48 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译： 下式（I）的化合物：其中a，b，R 1，R 2，R 3，R 4和R 6如本文所述，可用作血小板二磷酸腺苷的抑制剂 。 本文还描述了含有这些化合物的药物组合物，使用这些化合物作为抗血栓形成剂的方法和合成这些化合物的方法。
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公开(公告)号：US06555537B2
公开(公告)日：2003-04-29
申请号：US09726808
申请日：2000-11-29
申请人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
发明人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
IPC分类号： A61K31495
CPC分类号： C07D295/185 , C07D215/18 , C07D241/04 , C07D241/38 , C07D261/14 , C07D295/192 , C07D307/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： This invention is directed to acyl piperazine derivatives, for example, of the following formula (Ia): wherein R1a, R2, R3, R4, R5, and R6 are described herein. These derivatives are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the derivatives, and methods of using the derivatives to treat inflammatory disorders in humans.
摘要翻译： 本发明涉及例如下式（Ia）的酰基哌嗪衍生物：其中R1a，R2，R3，R4，R5和R6如本文所述。 这些衍生物可用作抗炎剂。 本发明还涉及含有衍生物的药物组合物，以及使用该衍生物治疗人类炎性疾病的方法。
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公开(公告)号：US06534509B1
公开(公告)日：2003-03-18
申请号：US09713881
申请日：2000-11-15
申请人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
发明人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
IPC分类号： A61K31495
CPC分类号： C07D295/185 , C07D215/18 , C07D241/04 , C07D241/38 , C07D261/14 , C07D295/192 , C07D307/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： This invention is directed to acyl piperazine derivatives, for example, of the following formula (1a): wherein R1a, R2, R3, R4, R5, and R6are descried herein. These derivatives are useful as anti-inflammatory agents. This invention is also directed to pharmacetutical compostions containing the derivatives, and methods of using the derivatives to treat inflammatory disorders in humans.
摘要翻译： 本发明涉及例如下式（1a）的酰基哌嗪衍生物：其中R1a，R2，R3，R4，R5和R6如本文所述。 这些衍生物可用作抗炎剂。 本发明还涉及含有衍生物的药物组合物，以及使用衍生物治疗人类炎症性疾病的方法。
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公开(公告)号：US06207665B1
公开(公告)日：2001-03-27
申请号：US09094397
申请日：1998-06-09
申请人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Guo Ping Wei , Wei Xu , Wei Zheng
发明人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Guo Ping Wei , Wei Xu , Wei Zheng
IPC分类号： A61K315377
CPC分类号： C07D295/185 , C07D215/18 , C07D241/04 , C07D241/38 , C07D261/14 , C07D295/192 , C07D307/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： This invention is directed to acyl piperazine derivatives of formula (Ia): wherein R1a, R2, R3, R4, R5 and R6 are defined herein, which are useful as anti-inflammatory agents. This invention is also directed to other acyl piperazine derivatives, pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
摘要翻译： 本发明涉及式（Ia）的酰基哌嗪衍生物：其中R1a，R2，R3，R4，R5和R6如本文所定义，其可用作抗炎剂。 本发明还涉及其它酰基哌嗪衍生物，含有本发明化合物的药物组合物，以及使用该化合物治疗人类炎性疾病的方法。
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公开(公告)号：US08008325B2
公开(公告)日：2011-08-30
申请号：US12332619
申请日：2008-12-11
申请人： Brad O. Buckman , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendong Yuan
发明人： Brad O. Buckman , Kumar Emayan , Imadul Islam , Karen May , Judi Bryant , Raju Mohan , Christopher West , Shendong Yuan
IPC分类号： A61K31/445 , C07D211/00
CPC分类号： C07F9/655345 , C07C323/58 , C07C327/34 , C07D211/34 , C07F9/301 , C07F9/302 , C07F9/306 , C07F9/3211 , C07F9/3241 , C07F9/3882 , C07F9/4006 , C07F9/4056 , C07F9/4087 , C07F9/6524
摘要： Compounds of the following formula (I), for example: wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译： 下列通式（I）的化合物，其中R1，R2，R3和R4如本文所述，可用作血浆羧肽酶B的抑制剂。含有这些化合物的药物组合物，使用这些化合物作为抗血栓形成剂和方法 用于合成这些化合物也在本文中描述。
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