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    In vitro engineered, regenerated urinary tract tissue compositions and methods for producing same
    3.
    发明申请
    In vitro engineered, regenerated urinary tract tissue compositions and methods for producing same 审中-公开
    体外工程化，再生尿道组织组合物及其制备方法

    公开(公告)号：US20050271635A1

    公开(公告)日：2005-12-08

    申请号：US11196990

    申请日：2005-08-04

    申请人： Bradley Kropp ,  Earl Cheng ,  Yuan Zhang ,  Rick Cowan ,  Peter Moore

    发明人： Bradley Kropp ,  Earl Cheng ,  Yuan Zhang ,  Rick Cowan ,  Peter Moore

    IPC分类号： A61F2/02 ,  A61K35/12 ,  C12N5/071 ,  A61K45/00

    CPC分类号： C12N5/0684 ,  A61F2/02 ,  A61K35/12 ,  C12N2502/1347 ,  C12N2502/23 ,  C12N2533/92

    摘要： A method for providing a urinary tract tissue graft composition includes providing a tissue culture frame and a segment of small intestinal submucosa and positioning the segment of small intestinal submucosa in the tissue culture frame such that the segment of small intestinal submucosa is suspended and held in a taut position by the tissue culture frame. Smooth muscle and urothelial cells are isolated from a tissue specimen of a subject and cultured, and then seeded upon the segment of small intestinal submucosa, thereby forming a urinary tract tissue graft. A tissue culture frame in which such a urinary tract tissue graft may be formed is also disclosed.

    摘要翻译： 提供尿道组织移植组合物的方法包括提供组织培养框架和小肠粘膜下层的一部分，并将小肠粘膜下层的部分定位在组织培养框架中，使得小肠粘膜下层的部分被悬浮并保持在 由组织培养框架拉紧位置。 从受试者的组织标本中分离平滑肌和尿路上皮细胞并培养，然后接种在小肠粘膜下层的段上，从而形成尿道组织移植物。 还公开了可以形成这种尿道组织移植物的组织培养框架。

    Vitro engineered, regenerated urinary tract tissue compositions and methods for producing same
    8.
    发明授权
    Vitro engineered, regenerated urinary tract tissue compositions and methods for producing same 失效
    体外工程化，再生尿道组织组合物及其制备方法

    公开(公告)号：US07122200B2

    公开(公告)日：2006-10-17

    申请号：US10013270

    申请日：2001-12-10

    申请人： Bradley P. Kropp ,  Earl Y. Cheng ,  Yuan Yuan Zhang ,  Rick Cowan ,  Peter Moore

    发明人： Bradley P. Kropp ,  Earl Y. Cheng ,  Yuan Yuan Zhang ,  Rick Cowan ,  Peter Moore

    IPC分类号： A61F13/00 ,  A01N65/00 ,  C12N5/08

    CPC分类号： C12N5/0684 ,  A61F2/02 ,  A61K35/12 ,  C12N2502/1347 ,  C12N2502/23 ,  C12N2533/92

    摘要： A method for providing a urinary tract tissue graft composition includes providing a tissue culture frame and a segment of small intestinal submucosa and positioning the segment of small intestinal submucosa in the tissue culture frame such that the segment of small intestinal submucosa is suspended and held in a taut position by the tissue culture frame. Smooth muscle and urothelial cells are isolated from a tissue specimen of a subject and cultured, and then seeded upon the segment of small intestinal submucosa, thereby forming a urinary tract tissue graft. A tissue culture frame in which such a urinary tract tissue graft may be formed is also disclosed.

    摘要翻译： 提供尿道组织移植组合物的方法包括提供组织培养框架和小肠粘膜下层的一部分，并将小肠粘膜下层的部分定位在组织培养框架中，使得小肠粘膜下层的部分被悬浮并保持在 由组织培养框架拉紧位置。 从受试者的组织标本中分离平滑肌和尿路上皮细胞并培养，然后接种在小肠粘膜下层的段上，从而形成尿道组织移植物。 还公开了可以形成这种尿道组织移植物的组织培养框架。