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8 条记录 (耗时 0.017 秒)

    Methods of providing gene expression profiles for metastatic cancer phenotypes utilizing differentially expressed transcripts associated with circulating tumor cells
    4.
    发明申请
    Methods of providing gene expression profiles for metastatic cancer phenotypes utilizing differentially expressed transcripts associated with circulating tumor cells 审中-公开
    使用与循环肿瘤细胞相关的差异表达的转录物提供转移性癌症表型的基因表达谱的方法

    公开(公告)号：US20070031876A1

    公开(公告)日：2007-02-08

    申请号：US11500631

    申请日：2006-08-08

    申请人： Hsueh-Kung Lin ,  Bradley Kropp

    发明人： Hsueh-Kung Lin ,  Bradley Kropp

    IPC分类号： C12Q1/68 ,  C12N1/08

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

    摘要： Methods of identifying the presence of differentially expressed transcripts associated with the presence of at least one circulating tumor cell in a biological sample of a cancer patient involves the use of suppression subtractive hybridization to identify differentially expressed transcripts present in biological samples of cancer patients not present in healthy patients, as well as differentially expressed transcripts present in biological samples of healthy patients and not present in the cancer patients. Utilizing these methods, a gene expression profile associated with a specific cancer phenotype can be constructed.

    摘要翻译： 识别与癌症患者的生物样品中存在至少一种循环肿瘤细胞相关的差异表达转录物的存在的方法涉及使用抑制消减杂交来鉴定存在于不存在于癌症患者的癌症患者的生物样品中的差异表达的转录物 健康的患者，以及存在于健康患者的生物样品中并且不存在于癌症患者中的差异表达的转录物。 利用这些方法，可以构建与特定癌症表型相关的基因表达谱。

    In vitro engineered, regenerated urinary tract tissue compositions and methods for producing same
    8.
    发明申请
    In vitro engineered, regenerated urinary tract tissue compositions and methods for producing same 审中-公开
    体外工程化，再生尿道组织组合物及其制备方法

    公开(公告)号：US20050271635A1

    公开(公告)日：2005-12-08

    申请号：US11196990

    申请日：2005-08-04

    申请人： Bradley Kropp ,  Earl Cheng ,  Yuan Zhang ,  Rick Cowan ,  Peter Moore

    发明人： Bradley Kropp ,  Earl Cheng ,  Yuan Zhang ,  Rick Cowan ,  Peter Moore

    IPC分类号： A61F2/02 ,  A61K35/12 ,  C12N5/071 ,  A61K45/00

    CPC分类号： C12N5/0684 ,  A61F2/02 ,  A61K35/12 ,  C12N2502/1347 ,  C12N2502/23 ,  C12N2533/92

    摘要： A method for providing a urinary tract tissue graft composition includes providing a tissue culture frame and a segment of small intestinal submucosa and positioning the segment of small intestinal submucosa in the tissue culture frame such that the segment of small intestinal submucosa is suspended and held in a taut position by the tissue culture frame. Smooth muscle and urothelial cells are isolated from a tissue specimen of a subject and cultured, and then seeded upon the segment of small intestinal submucosa, thereby forming a urinary tract tissue graft. A tissue culture frame in which such a urinary tract tissue graft may be formed is also disclosed.

    摘要翻译： 提供尿道组织移植组合物的方法包括提供组织培养框架和小肠粘膜下层的一部分，并将小肠粘膜下层的部分定位在组织培养框架中，使得小肠粘膜下层的部分被悬浮并保持在 由组织培养框架拉紧位置。 从受试者的组织标本中分离平滑肌和尿路上皮细胞并培养，然后接种在小肠粘膜下层的段上，从而形成尿道组织移植物。 还公开了可以形成这种尿道组织移植物的组织培养框架。