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1.发明申请Heterocyclic compounds process for their preparation and pharmceutical compositions containing them and their use in medicine 失效杂环化合物的制备方法和含有它们的药物组合物及其在医学中的应用公开(公告)号：US20050277678A1
公开(公告)日：2005-12-15
申请号：US10509894
申请日：2003-04-01
申请人： Braj Lohray , Vidya Lohray , Mukul Jain , Gautam Patel , Harikishore Pingali
发明人： Braj Lohray , Vidya Lohray , Mukul Jain , Gautam Patel , Harikishore Pingali
IPC分类号： A61K31/34 , A61K31/341 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4439 , A61K31/444 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/12 , A61P15/08 , A61P17/02 , A61P17/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P35/00 , C07D213/61 , C07D231/12 , C07D261/08 , C07D261/10 , C07D263/38 , C07D277/26 , C07D277/34 , C07D307/46 , C07D307/58 , C07D401/04 , C07D409/04 , A61K31/365 , A61K31/4152 , C07D43/02
CPC分类号： C07D409/04 , C07D213/61 , C07D231/12 , C07D261/08 , C07D261/10 , C07D263/38 , C07D277/34 , C07D307/58 , C07D401/04 , Y02P20/582
摘要： The present invention describes novel compounds having antiinflamatory activity, process for their preparation and pharmaceutical composition containing them.
摘要翻译： 本发明描述了具有抗炎活性的新化合物，其制备方法和含有它们的药物组合物。
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公开(公告)号：US20060142277A1
公开(公告)日：2006-06-29
申请号：US10534726
申请日：2003-11-14
申请人： Braj Lohray , Vidya Lohray , Mukul Jain , Sujay Basu , Harikishore Pingali , Saurin Raval , Preeti Raval
发明人： Braj Lohray , Vidya Lohray , Mukul Jain , Sujay Basu , Harikishore Pingali , Saurin Raval , Preeti Raval
IPC分类号： A61K31/5415 , A61K31/538 , A61K31/517 , A61K31/4704 , A61K31/426 , A61K31/422
CPC分类号： C07D207/325 , C07C43/23 , C07D209/08 , C07D209/86 , C07D213/30 , C07D215/14 , C07D235/06 , C07D239/91 , C07D261/08 , C07D265/38 , C07D279/16 , C07D405/04 , C07D409/04 , C07D413/04
摘要： The present invention relates to novel substituted aralkyl derivatives of the general formula (I) and (IIIa), their derivatives, their analogs, their tautomeric forms, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, pharmaceutical compositions containing them, use of these compounds in medicine and the intermediates involved in their preparation.
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公开(公告)号：US08772302B2
公开(公告)日：2014-07-08
申请号：US13377995
申请日：2010-06-17
IPC分类号： C07D411/12 , C07D411/14 , C07D413/14 , A61K31/454
CPC分类号： C07D411/12 , C07D411/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel GPR 119 agonists of the general Formula (I), their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, stereoisomers, and polymorphs. The invention also relates to processes for the preparation of the compounds of the invention, pharmaceutical compositions containing the compounds and to methods for treating one or both of diabetes and obesity using the compounds of the invention. The present invention is directed to G-protein coupled receptor (GPCR) agonists that are useful for the treatment of obesity, diabetes and related metabolic disorders.
摘要翻译： 本发明涉及通式（I）的新型GPR 119激动剂，其药学上可接受的盐，药学上可接受的溶剂化物，对映异构体，立体异构体和多晶型物。 本发明还涉及制备本发明化合物的方法，含有该化合物的药物组合物以及使用本发明化合物治疗糖尿病和肥胖中的一种或两种的方法。 本发明涉及可用于治疗肥胖，糖尿病和相关代谢紊乱的G蛋白偶联受体（GPCR）激动剂。
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公开(公告)号：US20120122905A1
公开(公告)日：2012-05-17
申请号：US13377995
申请日：2010-06-17
IPC分类号： A61K31/506 , C07D411/14 , A61P3/04 , C07D411/12 , A61K31/4535 , A61P3/10 , C07D413/14 , A61K31/454
CPC分类号： C07D411/12 , C07D411/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel GPR 119 agonists of the general Formula (I), their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, stereoisomers, and polymorphs. The invention also relates to processes for the preparation of the compounds of the invention, pharmaceutical compositions containing the compounds and to methods for treating one or both of diabetes and obesity using the compounds of the invention. The present invention is directed to G-protein coupled receptor (GPCR) agonists that are useful for the treatment of obesity, diabetes and related metabolic disorders.
摘要翻译： 本发明涉及通式（I）的新型GPR 119激动剂，其药学上可接受的盐，药学上可接受的溶剂化物，对映异构体，立体异构体和多晶型物。 本发明还涉及制备本发明化合物的方法，含有该化合物的药物组合物以及使用本发明化合物治疗糖尿病和肥胖中的一种或两种的方法。 本发明涉及可用于治疗肥胖，糖尿病和相关代谢紊乱的G蛋白偶联受体（GPCR）激动剂。
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公开(公告)号：US08742117B2
公开(公告)日：2014-06-03
申请号：US13141757
申请日：2009-12-22
IPC分类号： C07D401/00 , A61K31/505
CPC分类号： C07D413/14
摘要： The present invention relates to novel oxime derivatives of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
摘要翻译： 本发明涉及通式（I）的新型肟衍生物，其互变异构形式，其立体异构体，其药学上可接受的盐，含有它们的药物组合物，其制备方法，这些化合物在医药中的用途以及涉及它们的中间体 制备。
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6.发明授权Heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in medicine 失效杂环化合物的制备方法和含有它们的药物组合物及其在医药中的应用公开(公告)号：US07348342B2
公开(公告)日：2008-03-25
申请号：US10509894
申请日：2003-04-01
IPC分类号： A61K31/444 , A61K31/4439 , A61K31/426 , A61K31/421 , A61K31/42 , A61K31/4155 , A61K31/415 , C07D213/22 , C07D401/04 , C07D277/34 , C07D263/38 , C07D261/12 , C07D231/10 , C07D231/12
CPC分类号： C07D409/04 , C07D213/61 , C07D231/12 , C07D261/08 , C07D261/10 , C07D263/38 , C07D277/34 , C07D307/58 , C07D401/04 , Y02P20/582
摘要： We describe substituted benzenesulfoximine compounds having anti-inflammatory activity, processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of inflammatory diseases.
摘要翻译： 我们描述具有抗炎活性的取代苯磺酰亚胺化合物，其制备方法，含有它们的药物组合物及其在治疗炎性疾病中的用途。
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公开(公告)号：US08822414B2
公开(公告)日：2014-09-02
申请号：US13976598
申请日：2011-12-26
申请人： Harikishore Pingali , Pankaj Makadia , Vrajesh Pandya , Sairam Kalapatapu, V.V.M. , Mukul R. Jain
发明人： Harikishore Pingali , Pankaj Makadia , Vrajesh Pandya , Sairam Kalapatapu, V.V.M. , Mukul R. Jain
IPC分类号： A61K38/28 , A61P5/50 , C07D409/12 , C07D413/12 , A61K31/404 , A61K31/422 , A61K45/06 , C07D215/06 , C07D405/12 , A61K31/506 , A61K31/4433 , A61K31/4155 , A61K31/541 , C07D263/38 , A61K31/5377 , C07D309/04 , A61K31/4709 , C07D213/64 , A61K31/351 , C07D209/32 , A61K31/381 , C07D309/06 , C07D239/28 , A61K31/137
CPC分类号： C07D309/04 , A61K31/137 , A61K31/351 , A61K31/381 , A61K31/404 , A61K31/4155 , A61K31/422 , A61K31/4433 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D209/32 , C07D213/64 , C07D215/06 , C07D239/28 , C07D263/38 , C07D309/06 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation. The present invention is directed towards compounds which can be used to treat diseases such as Hyperlipidemia and also have a beneficial effect on cholesterol.
摘要翻译： 本发明涉及通式（I）的化合物，其互变异构形式，其立体异构体，其药学上可接受的盐，含有它们的药物组合物，其制备方法，这些化合物在医药中的用途以及参与其制备的中间体。 本发明涉及可用于治疗疾病如高脂血症的化合物，并且还对胆固醇具有有益作用。
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公开(公告)号：US08785463B2
公开(公告)日：2014-07-22
申请号：US13824552
申请日：2011-10-05
IPC分类号： A01N43/54 , A61K31/505 , A61K31/506 , C07D239/52
CPC分类号： A61K31/506 , C07D239/52 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel GPR 119 agonists of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
摘要翻译： 本发明涉及通式（I）的新型GPR 119激动剂，其互变异构形式，其立体异构体，其药学上可接受的盐，含有它们的药物组合物，其制备方法，这些化合物在医药中的用途以及涉及 他们的准备。
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公开(公告)号：US20120252796A1
公开(公告)日：2012-10-04
申请号：US13498705
申请日：2010-09-29
IPC分类号： A61K31/422 , C07D405/06 , A61K31/403 , C07D413/14 , G01N33/53 , A61K31/496 , C07D417/14 , A61K31/541 , A61P3/06 , C07D413/06 , A61K31/5377
CPC分类号： C07D413/06 , C07D405/06 , C07D413/14 , C07D417/06 , C07D417/14
摘要： The present invention relates to compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
摘要翻译： 本发明涉及通式（I）的化合物，其互变异构形式，其立体异构体，其药学上可接受的盐，含有它们的药物组合物，其制备方法，这些化合物在医药中的用途以及参与其制备的中间体。
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公开(公告)号：US20120028996A1
公开(公告)日：2012-02-02
申请号：US13141757
申请日：2009-12-22
IPC分类号： A61K31/506 , A61P3/04 , A61P3/10 , C07D413/14
CPC分类号： C07D413/14
摘要： The present invention relates to novel oxime derivatives of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
摘要翻译： 本发明涉及通式（I）的新型肟衍生物，其互变异构形式，其立体异构体，其药学上可接受的盐，含有它们的药物组合物，其制备方法，这些化合物在医药中的用途以及涉及它们的中间体 制备。
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