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公开(公告)号：US20110257374A1
公开(公告)日：2011-10-20
申请号：US13009764
申请日：2011-01-19
申请人： Brent S. Gaylord , Jean M. Wheeler , Glenn P. Bartholomew , Yongchao Liang , Janice W. Hong , William H. Huisman , Frank Peter Uckert , Lan T. Tran , Adrian Charles Vernon Palmer , Trung Nguyen , Russell A. Baldocchi
发明人： Brent S. Gaylord , Jean M. Wheeler , Glenn P. Bartholomew , Yongchao Liang , Janice W. Hong , William H. Huisman , Frank Peter Uckert , Lan T. Tran , Adrian Charles Vernon Palmer , Trung Nguyen , Russell A. Baldocchi
IPC分类号： C07K16/00 , C07C215/64 , C07C271/16 , C07C237/14 , C07C229/28 , C07H21/04 , C07C43/12 , C07C235/34 , C07C59/72 , C07K14/36 , C07D495/04 , C07F5/02 , C07C43/115
CPC分类号： G01N33/58 , C07K16/2812 , C07K16/2815 , C08G61/02 , C08G2261/1424 , C08G2261/3142 , C08G2261/411 , C09B68/41 , C12Q1/6818 , C12Q1/682 , G01N33/582 , H01L51/0039 , H01L51/0043
摘要： Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
摘要翻译： 本文描述了涉及中性共轭聚合物的方法，组合物和制品，包括用于合成具有沿着聚合物主链结构和末端封端单元的接头的中性共轭水溶性聚合物的方法。 这种聚合物可用于制造新的光电器件和开发高效生物传感器。 本发明还涉及这些聚合物在测定方法中的应用。
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公开(公告)号：US08455613B2
公开(公告)日：2013-06-04
申请号：US13065268
申请日：2011-03-17
申请人： Brent S. Gaylord , Jean M. Wheeler , Glenn P. Bartholomew , Frank Peter Uckert , Janice W. Hong , William H. Huisman
发明人： Brent S. Gaylord , Jean M. Wheeler , Glenn P. Bartholomew , Frank Peter Uckert , Janice W. Hong , William H. Huisman
CPC分类号： G01N33/58 , C07K16/2812 , C07K16/2815 , C08G61/02 , C08G2261/1424 , C08G2261/3142 , C08G2261/411 , C09B68/41 , C12Q1/6818 , C12Q1/682 , G01N33/582 , H01L51/0039 , H01L51/0043
摘要： Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
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公开(公告)号：US20110256550A1
公开(公告)日：2011-10-20
申请号：US13065315
申请日：2011-03-17
申请人： Brent S. Gaylord , Jean M. Wheeler , Glenn P. Bartholomew , Frank Peter Uckert , Janice W. Hong , William H. Huisman , Yongchao Liang
发明人： Brent S. Gaylord , Jean M. Wheeler , Glenn P. Bartholomew , Frank Peter Uckert , Janice W. Hong , William H. Huisman , Yongchao Liang
IPC分类号： G01N21/77 , C07C43/12 , C07F5/04 , C08G65/34 , C07D403/12 , C07C233/40 , C07K17/00 , C12M1/34 , C07C43/115 , C07C59/31
CPC分类号： G01N33/58 , C07K16/2812 , C07K16/2815 , C08G61/02 , C08G2261/1424 , C08G2261/3142 , C08G2261/411 , C09B68/41 , C12Q1/6818 , C12Q1/682 , G01N33/582 , H01L51/0039 , H01L51/0043
摘要： Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
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公开(公告)号：US08575303B2
公开(公告)日：2013-11-05
申请号：US13009764
申请日：2011-01-19
申请人： Brent S. Gaylord , Jean M. Wheeler , Glenn P. Bartholomew , Yongchao Liang , Janice W. Hong , William H. Huisman , Frank Peter Uckert , Lan T. Tran , Adrian Charles Vernon Palmer , Trung Nguyen , Russell A. Baldocchi
发明人： Brent S. Gaylord , Jean M. Wheeler , Glenn P. Bartholomew , Yongchao Liang , Janice W. Hong , William H. Huisman , Frank Peter Uckert , Lan T. Tran , Adrian Charles Vernon Palmer , Trung Nguyen , Russell A. Baldocchi
CPC分类号： G01N33/58 , C07K16/2812 , C07K16/2815 , C08G61/02 , C08G2261/1424 , C08G2261/3142 , C08G2261/411 , C09B68/41 , C12Q1/6818 , C12Q1/682 , G01N33/582 , H01L51/0039 , H01L51/0043
摘要： Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
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公开(公告)号：US08362193B2
公开(公告)日：2013-01-29
申请号：US13065315
申请日：2011-03-17
申请人： Brent S. Gaylord , Jean M. Wheeler , Glenn P. Bartholomew , Frank Peter Uckert , Janice W. Hong , William H. Huisman , Yongchao Liang
发明人： Brent S. Gaylord , Jean M. Wheeler , Glenn P. Bartholomew , Frank Peter Uckert , Janice W. Hong , William H. Huisman , Yongchao Liang
CPC分类号： G01N33/58 , C07K16/2812 , C07K16/2815 , C08G61/02 , C08G2261/1424 , C08G2261/3142 , C08G2261/411 , C09B68/41 , C12Q1/6818 , C12Q1/682 , G01N33/582 , H01L51/0039 , H01L51/0043
摘要： Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
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公开(公告)号：US20110256549A1
公开(公告)日：2011-10-20
申请号：US13065268
申请日：2011-03-17
申请人： Brent S. Gaylord , Jean M. Wheeler , Glenn P. Bartholomew , Frank Peter Uckert , Janice W. Hong , William H. Huisman
发明人： Brent S. Gaylord , Jean M. Wheeler , Glenn P. Bartholomew , Frank Peter Uckert , Janice W. Hong , William H. Huisman
IPC分类号： G01N33/53 , G01N30/96 , C07D207/40 , C07C43/20 , C07C59/72 , C07D403/12 , C07F5/02 , C07C233/29 , C07K16/00 , C07D207/444
CPC分类号： G01N33/58 , C07K16/2812 , C07K16/2815 , C08G61/02 , C08G2261/1424 , C08G2261/3142 , C08G2261/411 , C09B68/41 , C12Q1/6818 , C12Q1/682 , G01N33/582 , H01L51/0039 , H01L51/0043
摘要： Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
摘要翻译： 本文描述了涉及中性共轭聚合物的方法，组合物和制品，包括用于合成具有沿着聚合物主链结构和末端封端单元的接头的中性共轭水溶性聚合物的方法。 这种聚合物可用于制造新的光电器件和开发高效生物传感器。 本发明还涉及这些聚合物在测定方法中的应用。
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公开(公告)号：US08969509B2
公开(公告)日：2015-03-03
申请号：US13378989
申请日：2010-06-25
申请人： Bin Liu , Chun Wang , Ruoyu Zhan , Glenn P. Bartholomew , Janice W. Hong , Jean M. Wheeler , Brent S. Gaylord
发明人： Bin Liu , Chun Wang , Ruoyu Zhan , Glenn P. Bartholomew , Janice W. Hong , Jean M. Wheeler , Brent S. Gaylord
CPC分类号： C08G61/02 , C08G2261/3142 , C08G2261/3422 , C08G2261/5222
摘要： The devices and method are provided for detecting labeled and label-free analytes, such as nucleic acids and proteins, employing conjugated cationic, anionic and neutral polymers. The analytes can be immobilized on a solid support material. The solid support material can be disposed in the pre-fabricated patterns on a substrate. The chemical structures of the polymers employed by the various embodiments of the present invention are described herein.
摘要翻译： 提供的装置和方法用于检测标记和无标记分析物，如核酸和蛋白质，使用共轭阳离子，阴离子和中性聚合物。 分析物可以固定在固体支持材料上。 固体支撑材料可以以衬底上的预制图案设置。 本文描述了由本发明的各种实施方案采用的聚合物的化学结构。
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公开(公告)号：US20120252986A1
公开(公告)日：2012-10-04
申请号：US13378989
申请日：2010-06-25
申请人： Bin Liu , Chun Wang , Ruoyu Zhan , Glenn P. Bartholomew , Janice W. Hong , Jean M. Wheeler , Brent S. Gaylord
发明人： Bin Liu , Chun Wang , Ruoyu Zhan , Glenn P. Bartholomew , Janice W. Hong , Jean M. Wheeler , Brent S. Gaylord
IPC分类号： C08G65/00
CPC分类号： C08G61/02 , C08G2261/3142 , C08G2261/3422 , C08G2261/5222
摘要： The devices and method are provided for detecting labeled and label-free analytes, such as nucleic acids and proteins, employing conjugated cationic, anionic and neutral polymers. The analytes can be immobilized on a solid support material. The solid support material can be disposed in the pre-fabricated patterns on a substrate. The chemical structures of the polymers employed by the various embodiments of the present invention are described herein.
摘要翻译： 提供的装置和方法用于检测标记和无标记分析物，如核酸和蛋白质，使用共轭阳离子，阴离子和中性聚合物。 分析物可以固定在固体支持材料上。 固体支撑材料可以以衬底上的预制图案设置。 本文描述了由本发明的各种实施方案采用的聚合物的化学结构。
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9.发明申请Fluorescent Methods and Materials for Directed Biomarker Signal Amplification 有权用于定向生物标志物信号放大的荧光方法和材料公开(公告)号：US20120028828A1
公开(公告)日：2012-02-02
申请号：US13195747
申请日：2011-08-01
CPC分类号： G01N33/582 , C08G61/02 , C08G61/12 , C08G61/128 , C08G2261/3142 , C08G2261/3221 , C08G2261/3241 , C08G2261/3246 , C08G2261/522 , C08G2261/78 , C08G2261/94 , G01N33/542 , H01L51/0039 , Y10T436/13
摘要： Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.
摘要翻译： 提供了包括用于鉴定靶生物分子的多色素和/或多重色团合成物的方法和组合物。 传感器生物分子，例如抗体可以共价连接到多色素。 另外，信号发色团可以共价连接到多重色素。 这种布置使得信号发色团能够在多重色谱激发时能够从多重色淀中接收能量。 由于传感器生物分子能够与目标生物分子相互作用，多重色谱和/或多重色谱复合物可为目标生物分子提供增强的检测信号。
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10.发明授权Fluorescent methods and materials for directed biomarker signal amplification 有权用于定向生物标记信号放大的荧光方法和材料公开(公告)号：US08802450B2
公开(公告)日：2014-08-12
申请号：US13195747
申请日：2011-08-01
CPC分类号： G01N33/582 , C08G61/02 , C08G61/12 , C08G61/128 , C08G2261/3142 , C08G2261/3221 , C08G2261/3241 , C08G2261/3246 , C08G2261/522 , C08G2261/78 , C08G2261/94 , G01N33/542 , H01L51/0039 , Y10T436/13
摘要： Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.
摘要翻译： 提供了包括用于鉴定靶生物分子的多色素和/或多重色团合成物的方法和组合物。 传感器生物分子，例如抗体可以共价连接到多色素。 另外，信号发色团可以共价连接到多重色素。 这种布置使得信号发色团能够在多重色谱激发时能够从多重色淀中接收能量。 由于传感器生物分子能够与目标生物分子相互作用，多重色谱和/或多重色谱复合物可为目标生物分子提供增强的检测信号。
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