公开(公告)号：USD496973S1

公开(公告)日：2004-10-05

申请号：US29195537

申请日：2003-12-12

申请人： Bret Wahl ,  Marni Ines ,  Vinh-Duy Thai Nguyen ,  Michael Walker

设计人： Bret Wahl ,  Marni Ines ,  Vinh-Duy Thai Nguyen ,  Michael Walker

公开(公告)号：USD488201S1

公开(公告)日：2004-04-06

申请号：US29163726

申请日：2002-07-09

申请人： Bret Wahl ,  John B. Hoeflich ,  Marni Ines ,  Michael Walker

设计人： Bret Wahl ,  John B. Hoeflich ,  Marni Ines ,  Michael Walker

公开(公告)号：USD489106S1

公开(公告)日：2004-04-27

申请号：US29168702

申请日：2002-10-07

申请人： Bret Wahl ,  John B. Hoeflich ,  Sean Toulon ,  Michael Walker ,  Maresala Milo ,  Marni Ines

设计人： Bret Wahl ,  John B. Hoeflich ,  Sean Toulon ,  Michael Walker ,  Maresala Milo ,  Marni Ines

公开(公告)号：USD531688S1

公开(公告)日：2006-11-07

申请号：US29241379

申请日：2005-10-25

申请人： Nicholas Frame ,  Marni Ines ,  Jose Miraflor ,  Bret H. Wahl ,  Michael Walker

设计人： Nicholas Frame ,  Marni Ines ,  Jose Miraflor ,  Bret H. Wahl ,  Michael Walker

公开(公告)号：USD554212S1

公开(公告)日：2007-10-30

申请号：US29267550

申请日：2006-10-16

申请人： Robert Nunez ,  Craig Kevin Barez ,  Marni Ines ,  Michael Walker ,  Jose Miraflor

设计人： Robert Nunez ,  Craig Kevin Barez ,  Marni Ines ,  Michael Walker ,  Jose Miraflor

公开(公告)号：US20140064435A1

公开(公告)日：2014-03-06

申请号：US13822508

申请日：2012-05-18

申请人： Dirk Blavius ,  Erhard Friedrich ,  Bernd Block ,  Viktor Ruder ,  Corey Long ,  Michael Walker

发明人： Dirk Blavius ,  Erhard Friedrich ,  Bernd Block ,  Viktor Ruder ,  Corey Long ,  Michael Walker

IPC分类号： G21C3/356

CPC分类号： G21C3/3566 ,  G21C3/332 ,  G21C3/34 ,  Y02E30/40

摘要： A nuclear fuel assembly for boiling water reactor is provided. The nuclear fuel assembly includes a base, a head, a bundle of fuel rods extending longitudinally between the base and the head, a tubular fuel channel encasing the bundle of fuel rods, and at least one fuel channel spacer for transversely spacing the fuel assembly from an adjacent element. The or each fuel channel spacer includes a support having at least one plate and at least one corresponding leaf spring supported by the corresponding plate, the or each plate being fixed to a corresponding sidewall of the fuel channel.

摘要翻译： 提供了一种用于沸水反应堆的核燃料组件。 核燃料组件包括基座，头部，在基部和头部之间纵向延伸的一组燃料棒，包围燃料棒束的管状燃料通道，以及用于将燃料组件横向间隔开的至少一个燃料通道间隔件 相邻元素。 该或每个燃料通道间隔件包括具有至少一个板的支撑件和由对应的板支撑的至少一个对应的板簧，该板或每个板固定到燃料通道的相应侧壁。

公开(公告)号：US08273544B2

公开(公告)日：2012-09-25

申请号：US13083156

申请日：2011-04-08

申请人： Wendy J. Fantl ,  David B. Rosen ,  Alessandra Cesano ,  Santosh K. Putta ,  James R. Hackett ,  Michael Walker ,  Jing Shi

发明人： Wendy J. Fantl ,  David B. Rosen ,  Alessandra Cesano ,  Santosh K. Putta ,  James R. Hackett ,  Michael Walker ,  Jing Shi

IPC分类号： G01N33/53 ,  G01N33/567 ,  G01N33/00

CPC分类号： G01N33/57426 ,  A61K31/4709 ,  A61K31/513 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/7076 ,  G01N33/50 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/5047 ,  G01N33/5055 ,  G01N33/5073 ,  G01N33/5094 ,  G01N33/53 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/6893 ,  G01N2333/705 ,  G01N2800/22 ,  G01N2800/52

摘要： The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

公开(公告)号：US20110269154A1

公开(公告)日：2011-11-03

申请号：US13083156

申请日：2011-04-08

申请人： Wendy J. FANTL ,  David B. Rosen ,  Alessandra Cesano ,  Santosh K. Putta ,  James R. Hackett ,  Michael Walker ,  Jing Shi

发明人： Wendy J. FANTL ,  David B. Rosen ,  Alessandra Cesano ,  Santosh K. Putta ,  James R. Hackett ,  Michael Walker ,  Jing Shi

IPC分类号： G01N33/567 ,  G01N33/574

CPC分类号： G01N33/57426 ,  A61K31/4709 ,  A61K31/513 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/7076 ,  G01N33/50 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/5047 ,  G01N33/5055 ,  G01N33/5073 ,  G01N33/5094 ,  G01N33/53 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/6893 ,  G01N2333/705 ,  G01N2800/22 ,  G01N2800/52

摘要： The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

摘要翻译： 本发明提供了用于确定单细胞中多种蛋白质的活化状态的方法。 这种方法允许基于活化状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及在细胞群体内表现出相关的激活变化的细胞亚群的鉴定。 此外，这种方法允许细胞活动或性质的相关性。 此外，使用细胞激活的调节剂允许表征途径和细胞群体。 可以使用本发明分析的几种示例性疾病包括AML，MDS和MPN。

公开(公告)号：USD647985S1

公开(公告)日：2011-11-01

申请号：US29380776

申请日：2010-12-10

申请人： Zac Atwell ,  Robert Nunez ,  Chris Piniarski ,  Brian Bazzel ,  Sean Toulon ,  Bret H. Wahl ,  Allan Capili Saliba ,  Marni D. Ines ,  Michael Walker

设计人： Zac Atwell ,  Robert Nunez ,  Chris Piniarski ,  Brian Bazzel ,  Sean Toulon ,  Bret H. Wahl ,  Allan Capili Saliba ,  Marni D. Ines ,  Michael Walker

公开(公告)号：US20110250206A1

公开(公告)日：2011-10-13

申请号：US13026181

申请日：2011-02-11

申请人： Robert C. Axtell ,  Lawrence Steinman ,  May H. Han ,  Brigit A. de Jong ,  Chander Raman ,  Michael Walker ,  Jing Shi ,  Tito A. Serafini

发明人： Robert C. Axtell ,  Lawrence Steinman ,  May H. Han ,  Brigit A. de Jong ,  Chander Raman ,  Michael Walker ,  Jing Shi ,  Tito A. Serafini

IPC分类号： A61K39/395 ,  A61P3/10 ,  A61P11/06 ,  G06F19/00 ,  A61P1/16 ,  A61P25/16 ,  A61P9/10 ,  A61P3/04 ,  A61P29/00 ,  A61P11/00

CPC分类号： A61K31/225 ,  A61K31/18 ,  G01N33/6863 ,  G01N33/6896 ,  G01N2333/54 ,  G01N2800/285 ,  Y02A90/26

摘要： Compositions and methods are provided for prognostic classification of inflammatory diseases, e.g. inflammatory demyelinating disease, patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Assessment of this signature pattern thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is multiple sclerosis or neuromyelitis optica.