公开(公告)号：US08190270B2

公开(公告)日：2012-05-29

申请号：US13347675

申请日：2012-01-10

申请人： Brett M. Wingeier ,  Martha Morrell ,  Carl Lance Boling

发明人： Brett M. Wingeier ,  Martha Morrell ,  Carl Lance Boling

IPC分类号： A61N1/00

CPC分类号： A61N1/0529 ,  A61N1/0536 ,  A61N1/0568

摘要： Medical electrical lead systems and related methods are described. The medical electrical lead systems may be configured to be at least partially implanted in a body of a subject. Some variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and a lumen extending at least partially therebetween, at least one electrode in the proximity of the distal end of the lead body, and a reservoir in fluid communication with the lumen, where the reservoir is located at a position removed from the distal end of the lead body. Certain variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and first and second lumens extending at least partially therebetween, and at least one electrode in the proximity of the distal end of the lead body.

摘要翻译： 描述医用电引线系统及相关方法。 医疗电引线系统可以被配置为至少部分地植入受试者的身体。 医疗电引线系统的一些变型可以包括引线主体，引线主体包括近端和远端以及至少部分延伸到其间的内腔，在引线主体的远端附近的至少一个电极和 与内腔流体连通，其中储存器位于从引线主体的远端移除的位置。 医疗电引线系统的某些变型可以包括引线本体，该引线主体包括近端和远端以及至少部分地延伸的第一和第二内腔以及在引线主体的远端附近的至少一个电极。

公开(公告)号：US08160720B2

公开(公告)日：2012-04-17

申请号：US12881171

申请日：2010-09-13

申请人： Brett M. Wingeier ,  Martha Morrell ,  Carl Lance Boling

发明人： Brett M. Wingeier ,  Martha Morrell ,  Carl Lance Boling

IPC分类号： A61N1/00

CPC分类号： A61N1/0529 ,  A61N1/0536 ,  A61N1/0568

摘要： Medical electrical lead systems and related methods are described. The medical electrical lead systems may be configured to be at least partially implanted in a body of a subject. Some variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and a lumen extending at least partially therebetween, at least one electrode in the proximity of the distal end of the lead body, and a reservoir in fluid communication with the lumen, where the reservoir is located at a position removed from the distal end of the lead body. Certain variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and first and second lumens extending at least partially therebetween, and at least one electrode in the proximity of the distal end of the lead body.

公开(公告)号：US08311632B2

公开(公告)日：2012-11-13

申请号：US12392938

申请日：2009-02-25

申请人： Benjamin David Pless ,  Carl Lance Boling ,  Barbara Gibb ,  Adolf van der Heide ,  Brett M. Wingeier

发明人： Benjamin David Pless ,  Carl Lance Boling ,  Barbara Gibb ,  Adolf van der Heide ,  Brett M. Wingeier

IPC分类号： A61N1/00

CPC分类号： A61N1/3785 ,  H02N2/18 ,  H02N11/002

摘要： In some embodiments, the power generator for converting mechanical energy to electrical energy is described may include a compressible element adapted and configured to be placed in an environment having a variable compressive force such as varying ambient pressures. The compressible element may be compressed by a force applied by the variable pressure to the compressible element. The power generator may further include a transducer that may be coupled to the compressible element and that may convert mechanical energy from the compression of the compressible element to electrical energy. In some embodiments, the power generator may be adapted to be an implantable power generator for converting mechanical energy from a patient to electrical energy, such that the compressible element adapted and configured to be placed between two adjacent tissue layers of the patient and to be compressed by a force applied from the two adjacent tissue layers to the compressible element.

摘要翻译： 在一些实施例中，描述了用于将机械能转换成电能的功率发生器可以包括可压缩元件，该可压缩元件适于并被配置为放置在具有可变压缩力（例如变化的环境压力）的环境中。 可压缩元件可以通过由可变压力施加到可压缩元件的力而被压缩。 发电机还可以包括可耦合到可压缩元件并且可将机械能从可压缩元件的压缩转换为电能的换能器。 在一些实施例中，发电机可以适于作为可植入的发电机，用于将来自患者的机械能转换成电能，使得可压缩元件适于并被配置成放置在患者的两个相邻组织层之间并被压缩 通过从两个相邻组织层施加到可压缩元件的力。

公开(公告)号：US20090216292A1

公开(公告)日：2009-08-27

申请号：US12392938

申请日：2009-02-25

申请人： Benjamin David Pless ,  Carl Lance Boling ,  Barbara Gibb ,  Adolf van der Heide ,  Brett M. Wingeier

发明人： Benjamin David Pless ,  Carl Lance Boling ,  Barbara Gibb ,  Adolf van der Heide ,  Brett M. Wingeier

IPC分类号： A61N1/378 ,  H02K7/18 ,  H02N11/00 ,  H02N2/18

CPC分类号： A61N1/3785 ,  H02N2/18 ,  H02N11/002

摘要： In some embodiments, the power generator for converting mechanical energy to electrical energy is described may include a compressible element adapted and configured to be placed in an environment having a variable compressive force such as varying ambient pressures. The compressible element may be compressed by a force applied by the variable pressure to the compressible element. The power generator may further include a transducer that may be coupled to the compressible element and that may convert mechanical energy from the compression of the compressible element to electrical energy. In some embodiments, the power generator may be adapted to be an implantable power generator for converting mechanical energy from a patient to electrical energy, such that the compressible element adapted and configured to be placed between two adjacent tissue layers of the patient and to be compressed by a force applied from the two adjacent tissue layers to the compressible element.

摘要翻译： 在一些实施例中，描述了用于将机械能转换成电能的功率发生器可以包括可压缩元件，该可压缩元件适于并被配置为放置在具有可变压缩力（例如变化的环境压力）的环境中。 可压缩元件可以通过由可变压力施加到可压缩元件的力而被压缩。 发电机还可以包括可耦合到可压缩元件并且可将机械能从可压缩元件的压缩转换为电能的换能器。 在一些实施例中，发电机可以适于作为可植入的发电机，用于将来自患者的机械能转换成电能，使得可压缩元件适于并被配置成放置在患者的两个相邻组织层之间并被压缩 通过从两个相邻组织层施加到可压缩元件的力。

公开(公告)号：US20130073003A1

公开(公告)日：2013-03-21

申请号：US13674729

申请日：2012-11-12

申请人： Benjamin David Pless ,  Carl Lance Boling ,  Barbara Gibb ,  Adolf van der Heide ,  Brett M. Wingeier

发明人： Benjamin David Pless ,  Carl Lance Boling ,  Barbara Gibb ,  Adolf van der Heide ,  Brett M. Wingeier

IPC分类号： A61N1/378

CPC分类号： A61N1/3785 ,  H02N2/18 ,  H02N11/002

摘要： In some embodiments, the power generator for converting mechanical energy to electrical energy may include a compressible element adapted and configured to be placed in an environment having a variable compressive force such as varying ambient pressures. The compressible element may be compressed by a force applied by the variable pressure to the compressible element. The power generator may further include a transducer that may be coupled to the compressible element and that may convert mechanical energy from the compression of the compressible element to electrical energy. In some embodiments, the power generator may be adapted to be an implantable power generator for converting mechanical energy from a patient to electrical energy, such that the compressible element adapted and configured to be placed between two adjacent tissue layers of the patient and to be compressed by a force applied from the two adjacent tissue layers to the compressible element.

摘要翻译： 在一些实施例中，用于将机械能转换成电能的发电机可以包括可压缩元件，该可压缩元件适于并被配置为放置在具有可变压缩力（例如变化的环境压力）的环境中。 可压缩元件可以通过由可变压力施加到可压缩元件的力而被压缩。 发电机还可以包括可耦合到可压缩元件并且可将机械能从可压缩元件的压缩转换为电能的换能器。 在一些实施例中，发电机可以适于作为可植入的发电机，用于将来自患者的机械能转换成电能，使得可压缩元件适于并被配置成放置在患者的两个相邻组织层之间并被压缩 通过从两个相邻组织层施加到可压缩元件的力。

公开(公告)号：US20120109253A1

公开(公告)日：2012-05-03

申请号：US13347675

申请日：2012-01-10

申请人： Brett M. Wingeier ,  Martha Morrell ,  C. Lance Boling

发明人： Brett M. Wingeier ,  Martha Morrell ,  C. Lance Boling

IPC分类号： A61N1/36

CPC分类号： A61N1/0529 ,  A61N1/0536 ,  A61N1/0568

摘要： Medical electrical lead systems and related methods are described. The medical electrical lead systems may be configured to be at least partially implanted in a body of a subject. Some variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and a lumen extending at least partially therebetween, at least one electrode in the proximity of the distal end of the lead body, and a reservoir in fluid communication with the lumen, where the reservoir is located at a position removed from the distal end of the lead body. Certain variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and first and second lumens extending at least partially therebetween, and at least one electrode in the proximity of the distal end of the lead body.

摘要翻译： 描述医用电引线系统及相关方法。 医疗电引线系统可以被配置为至少部分地植入受试者的身体。 医疗电引线系统的一些变型可以包括引线主体，引线主体包括近端和远端以及至少部分延伸到其间的内腔，在引线主体的远端附近的至少一个电极和 与内腔流体连通，其中储存器位于从引线主体的远端移除的位置。 医疗电引线系统的某些变型可以包括引线本体，该引线主体包括近端和远端以及至少部分地延伸的第一和第二内腔以及在引线主体的远端附近的至少一个电极。

公开(公告)号：US20130172774A1

公开(公告)日：2013-07-04

申请号：US13539301

申请日：2012-06-30

申请人： Tara L. Crowder ,  Brett M. Wingeier ,  Martha J. Morrell ,  Felice Sun ,  Thomas Tcheng

发明人： Tara L. Crowder ,  Brett M. Wingeier ,  Martha J. Morrell ,  Felice Sun ,  Thomas Tcheng

IPC分类号： A61B5/04 ,  A61B5/00

CPC分类号： A61B5/04 ,  A61B5/0002 ,  A61B5/0022 ,  A61B5/04001 ,  A61B5/0484 ,  A61B5/14539 ,  A61B5/14553 ,  A61B5/4082 ,  A61B5/4094 ,  A61B5/4848

摘要： Systems and methods rely on feedback from an active medical device or devices (e.g., neurostimulator coupled to sensing and stimulation elements such as electrodes) to assess the effectiveness of a patient's drug regimen. Such reliance may include analyzing characteristics in physiological data acquired by the medical device(s), for example, in the form of responses evoked from the patient by electrical stimulation waveforms. Systems and methods further involved adjusting one or more parameters according to which a combination therapy consisting of at least a drug regimen and an electrical stimulation therapy are delivered to a patient, in an effort to optimize the therapeutic effect of the combination. The adjustments may be automatically by one or more implanted or external hosts working together or alone, and/or with the input of a physician.

摘要翻译： 系统和方法依赖于来自有源医疗装置或装置（例如耦合到感测和刺激元件例如电极的神经刺激器）的反馈来评估患者药物方案的有效性。 这种依赖可以包括分析由医疗设备获取的生理数据中的特征，例如以电刺激波形从患者诱发的反应形式。 系统和方法还包括调整一个或多个参数，根据该参数，将由至少药物方案和电刺激疗法组合的组合治疗递送给患者，以努力优化组合的治疗效果。 一个或多个植入的或外部的主机可以一起或单独地和/或与医生的输入自动进行调整。

公开(公告)号：US20100305664A1

公开(公告)日：2010-12-02

申请号：US12791690

申请日：2010-06-01

申请人： Brett M. Wingeier ,  Benjamin David Pless ,  Anthony V. Caparso ,  Margaret McLaughlin

发明人： Brett M. Wingeier ,  Benjamin David Pless ,  Anthony V. Caparso ,  Margaret McLaughlin

IPC分类号： A61N1/36

CPC分类号： A61N1/36007 ,  A61N1/0507 ,  A61N1/3605 ,  A61N1/36114 ,  A61N1/36121

摘要： An implantable medical device is provided for the treatment of a variety of disorders. The implantable medical device can be a neurostimulator having a stimulation lead and electrode(s) configured to be implanted on or near neural tissue in communication with the adrenal gland. Application of an electrical waveform to the neural tissue can cause the adrenal gland to release catecholamines to treat hypoglycemia. In other embodiments, chemical, magnetic, optical, or mechanical neuromodulation can be used.

摘要翻译： 提供可植入医疗装置用于治疗各种疾病。 可植入医疗装置可以是具有刺激引线和电极的神经刺激器，该刺激引线和电极被配置为植入在与肾上腺连通的神经组织上或附近。 将电波形应用于神经组织可导致肾上腺释放儿茶酚胺以治疗低血糖。 在其它实施例中，可以使用化学，磁性，光学或机械神经调节。

公开(公告)号：US09186082B2

公开(公告)日：2015-11-17

申请号：US11811190

申请日：2007-06-07

申请人： Brett M. Wingeier ,  Thomas K. Tcheng

发明人： Brett M. Wingeier ,  Thomas K. Tcheng

IPC分类号： A61B5/04 ,  A61B5/0476 ,  A61B5/048 ,  A61B5/0484 ,  A61B5/00 ,  A61B5/07

CPC分类号： A61B5/0476 ,  A61B5/0031 ,  A61B5/048 ,  A61B5/0484 ,  A61B5/076 ,  A61B5/16 ,  A61B5/4094 ,  A61B5/7257

摘要： A system and method for detecting and predicting neurological events with an implantable device uses a relatively low-power central processing unit in connection with signal processing circuitry to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in one or more electrographic signals received from a patient's brain. The features and window-based characteristics are employed within the framework of a programmable finite state machine to identify patterns and sequences in and across the electrographic signals, facilitating early and reliable detection and prediction of complex spatiotemporal neurological events in real time, and enabling responsive action by the implantable device.

摘要翻译： 使用可植入装置检测和预测神经病学的系统和方法使用与信号处理电路相关联的相对低功率的中央处理单元来识别特征（包括半波）并计算基于窗口的特征（包括线路长度和面积 波形的曲线）在从患者的大脑接收的一个或多个电描记信号中。 在可编程有限状态机的框架内采用特征和基于窗口的特征，以识别和跨越电图像信号的图案和序列，便于实时地对复杂的时空神经事件进行早期可靠的检测和预测，并且能够实现响应动作 通过可植入装置。

公开(公告)号：US20110004282A1

公开(公告)日：2011-01-06

申请号：US12871865

申请日：2010-08-30

申请人： C. Lance Boling ,  Daniel Chao ,  Martha J. Morrell ,  Benjamin D. Pless ,  Thomas K. Tcheng ,  Brett M. Wingeier

发明人： C. Lance Boling ,  Daniel Chao ,  Martha J. Morrell ,  Benjamin D. Pless ,  Thomas K. Tcheng ,  Brett M. Wingeier

IPC分类号： A61N1/05

CPC分类号： A61N1/0529 ,  A61N1/0536 ,  A61N1/0539 ,  A61N1/0551 ,  A61N1/36082 ,  B22F3/10 ,  B22F2003/241 ,  B22F2003/242 ,  B22F2998/10 ,  B22F3/24

摘要： Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Examples of bioactive agents that may be used in the lead system include bioactive agents that promote neural adhesion and living cells that have been biologically manipulated, engineered cells, and cells of a particular phenotype and/or adapted to induce a desired neural or glial response. Methods described herein may comprise contacting the substrate of a lead body and/or an electrode of a medical electrical lead system with at least one bioactive agent, where the lead body and the electrode are connected to each other.

摘要翻译： 描述医用电引线系统及相关方法。 引导系统可以被配置为至少部分地植入受试者的神经组织，例如受试者的脑部。 引线系统的一些变型可以包括引线体，连接到引线主体的电极和生物活性剂。 电极和/或引线主体可以包括衬底，并且生物活性剂可以由衬底支撑（例如，通过衬底的大部分区域）。 可用于引导系统的生物活性剂的实例包括促进神经粘附的生物活性剂和已被生物操作的工程细胞，特定表型的细胞和/或适于诱导所需神经或神经胶质反应的活细胞。 本文描述的方法可以包括将铅体的基底和/或医用电引线系统的电极与至少一种生物活性剂接触，其中引线体和电极彼此连接。