公开(公告)号：US20100092535A1

公开(公告)日：2010-04-15

申请号：US12249611

申请日：2008-10-10

申请人： Brian Cook ,  James Mitchell ,  Feridun Ozdil ,  Natividad Vasquez

发明人： Brian Cook ,  James Mitchell ,  Feridun Ozdil ,  Natividad Vasquez

IPC分类号： A61K9/00 ,  A61K39/395 ,  A61F2/82

CPC分类号： A61F2/04 ,  A61F2/82 ,  A61F2250/0067 ,  A61L17/005 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/256 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/432 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2400/12

摘要： Disclosed herein are controlled release drug delivery systems. The systems comprise a medical device at least one nonoporous surface, at least one bioactive agent and optionally a biodegradable polymer. The nanoporous surfaces of the medical devices contain nanopores capable of acting as reservoirs for drugs that are controllably released.

摘要翻译： 本文公开了控释药物递送系统。 该系统包括至少一个非孔表面的医疗装置，至少一种生物活性剂和任选的可生物降解的聚合物。 医疗装置的纳米多孔表面含有能够作为可控制释放的药物的储存器的纳米孔。

公开(公告)号：US20090093871A1

公开(公告)日：2009-04-09

申请号：US11868742

申请日：2007-10-08

申请人： Susan Rea ,  Feridun Ozdil ,  Robert Rajalingam ,  Noreen F. Moloney ,  Jeffrey Allen ,  Matthew J. Birdsall ,  Darrel Untereker ,  Jeffrey Gross ,  Mark Dolan

发明人： Susan Rea ,  Feridun Ozdil ,  Robert Rajalingam ,  Noreen F. Moloney ,  Jeffrey Allen ,  Matthew J. Birdsall ,  Darrel Untereker ,  Jeffrey Gross ,  Mark Dolan

IPC分类号： A61F2/06

CPC分类号： A61F2/90 ,  A61F2250/0068

摘要： A system for treating a vascular condition includes a catheter and a stent disposed on the catheter. The stent includes tubing having a wall defining a central lumen and a plurality of holes. The system further includes a therapeutic agent disposed within the central lumen of the tubing. A method of manufacturing a therapeutic agent carrying stent includes inserting a therapeutic agent within a therapeutic agent delivery system into the central lumen of a hollow metal tube and forming a stent framework from the hollow tube.

摘要翻译： 用于治疗血管状态的系统包括导管和设置在导管上的支架。 支架包括具有限定中心腔和多个孔的壁的管。 该系统还包括设置在管的中心腔内的治疗剂。 制造治疗剂携带支架的方法包括将治疗剂递送系统内的治疗剂插入中空金属管的中心腔，并从中空管形成支架框架。

公开(公告)号：US20090171265A1

公开(公告)日：2009-07-02

申请号：US12363872

申请日：2009-02-02

申请人： David Doty ,  Feridun Ozdil ,  Josiah Wilcox ,  Robret Murray ,  Prasad Kilari

发明人： David Doty ,  Feridun Ozdil ,  Josiah Wilcox ,  Robret Murray ,  Prasad Kilari

IPC分类号： A61M37/00

CPC分类号： A61B17/12136 ,  A61B17/12045 ,  A61B17/12109 ,  A61B2017/12127 ,  A61B2017/22085 ,  A61M25/1011 ,  A61M2025/09008 ,  A61M2025/1052 ,  A61N5/0601 ,  A61N5/062

摘要： A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes a catheter having a first inflatable member and a guidewire having a second inflatable member. The catheter has an extended tip distal to the first inflatable member that includes multiple perfusion ports. A light emission coil is disposed on the extended tip with individual coil loops interspaced with the perfusion ports. In a method, the guidewire is delivered to a treatment site within a vessel. The catheter is delivered to the treatment site over the guidewire. The inflatable members are inflated to form an enclosed treatment space within the vessel. A photoinitiator is delivered to the enclosed treatment space. Excess photoinitiator is flushed from the treatment space, and a prepolymer is delivered. The prepolymer is cured by light delivered by the light emission coil.

摘要翻译： 通过光聚合将聚合物（水凝胶）施加到容器的内表面的系统包括具有第一可充气构件和具有第二可充气构件的导丝的导管。 导管具有远离第一可充气构件的延伸尖端，其包括多个灌注端口。 发光线圈设置在延伸尖端上，其中单个线圈环与灌注端口间隔开。 在一种方法中，将导丝输送到血管内的治疗部位。 导管通过导丝输送到治疗部位。 充气构件被充气以在容器内形成封闭的处理空间。 光引发剂被输送到封闭的处理空间。 从处理空间冲洗过量的光引发剂，并递送预聚物。 预聚物由发光线圈输送的光固化。

公开(公告)号：US20090035351A1

公开(公告)日：2009-02-05

申请号：US12212817

申请日：2008-09-18

申请人： Joseph Berglund ,  Ankit Shah ,  Feridun Ozdil ,  Christopher Bonny

发明人： Joseph Berglund ,  Ankit Shah ,  Feridun Ozdil ,  Christopher Bonny

IPC分类号： A61F2/82

CPC分类号： A61F2/88 ,  A61F2/022 ,  A61F2/82 ,  A61F2/885 ,  A61F2250/003 ,  A61F2250/0035 ,  A61F2250/0068

摘要： A biodegradable implantable device for delivering a drug to a treatment site includes a biodegradable hypotube defining a lumen and at least one drug disposed within the lumen of the hypotube. At least one drug is released from the lumen upon degradation of the biodegradable hypotube. The lumen may be compartmentalized, each compartment containing a different drug. The hypotube may also include a plurality of pores in fluid communication with the compartments providing different drug release profiles.

摘要翻译： 用于将药物递送到治疗部位的可生物降解的可植入装置包括限定内腔的可生物降解的海波管和设置在海波管内腔内的至少一种药物。 在降解可生物降解海波管时，至少有一种药物从内腔释放。 腔可以是间隔的，每个隔室含有不同的药物。 海波管还可以包括与隔室流体连通以提供不同药物释放曲线的多个孔。

公开(公告)号：US20070010782A1

公开(公告)日：2007-01-11

申请号：US11166850

申请日：2005-06-23

申请人： David Doty ,  Feridun Ozdil ,  Josiah Wilcox ,  Robert Murray ,  Prasad Kilari

发明人： David Doty ,  Feridun Ozdil ,  Josiah Wilcox ,  Robert Murray ,  Prasad Kilari

IPC分类号： A61N1/30 ,  A61B18/18

CPC分类号： A61B17/12136 ,  A61B17/12045 ,  A61B17/12109 ,  A61B2017/12127 ,  A61B2017/22085 ,  A61M25/1011 ,  A61M2025/09008 ,  A61M2025/1052 ,  A61N5/0601 ,  A61N5/062

摘要： A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes a catheter having a first inflatable member and a guidewire having a second inflatable member. The catheter has an extended tip distal to the first inflatable member that includes multiple perfusion ports. A light emission coil is disposed on the extended tip with individual coil loops interspaced with the perfusion ports. In a method, the guidewire is delivered to a treatment site within a vessel. The catheter is delivered to the treatment site over the guidewire. The inflatable members are inflated to form an enclosed treatment space within the vessel. A photoinitiator is delivered to the enclosed treatment space. Excess photoinitiator is flushed from the treatment space, and a prepolymer is delivered. The prepolymer is cured by light delivered by the light emission coil.

摘要翻译： 通过光聚合将聚合物（水凝胶）施加到容器的内表面的系统包括具有第一可充气构件和具有第二可充气构件的导丝的导管。 导管具有远离第一可充气构件的延伸尖端，其包括多个灌注端口。 发光线圈设置在延伸尖端上，其中单个线圈环与灌注端口间隔开。 在一种方法中，将导丝输送到血管内的治疗部位。 导管通过导丝输送到治疗部位。 充气构件被充气以在容器内形成封闭的处理空间。 光引发剂被输送到封闭的处理空间。 从处理空间冲洗过量的光引发剂，并递送预聚物。 预聚物由发光线圈输送的光固化。

公开(公告)号：US07749262B2

公开(公告)日：2010-07-06

申请号：US11252450

申请日：2005-10-17

申请人： Feridun Ozdil ,  Junghwa Jenn Cho ,  Joseph Berglund ,  Susan Rea

发明人： Feridun Ozdil ,  Junghwa Jenn Cho ,  Joseph Berglund ,  Susan Rea

IPC分类号： A61F2/06

CPC分类号： A61F2/92 ,  A61F2/91 ,  A61F2/958 ,  A61F2220/0008 ,  A61F2230/0054

摘要： An intraluminal stent, an intraluminal stent delivery system, and a method of treating a vascular condition. The stent includes a framework with a plurality of flap portions projecting substantially beyond a central core region. The flap portions are movable from a compressed position and an extended position when the stent is deployed. The system includes a catheter and the intraluminal stent. The method includes positioning an intraluminal stent within a vessel. A plurality of flap portions of the stent is extended from a compressed position into contact with the vessel.

摘要翻译： 管腔内支架，腔内支架输送系统和治疗血管病变的方法。 支架包括具有大致突出超过中心芯区域的多个翼片部分的框架。 当支架展开时，翼片部分可从压缩位置和伸出位置移动。 该系统包括导管和管腔内支架。 该方法包括将管腔内支架定位在血管内。 支架的多个翼片部分从压缩位置延伸以与血管接触。

公开(公告)号：US20070088427A1

公开(公告)日：2007-04-19

申请号：US11252450

申请日：2005-10-17

申请人： Feridun Ozdil ,  Junghwa Cho ,  Joseph Berglund ,  Susan Rea

发明人： Feridun Ozdil ,  Junghwa Cho ,  Joseph Berglund ,  Susan Rea

IPC分类号： A61F2/06

CPC分类号： A61F2/92 ,  A61F2/91 ,  A61F2/958 ,  A61F2220/0008 ,  A61F2230/0054

摘要： An intraluminal stent, an intraluminal stent delivery system, and a method of treating a vascular condition. The stent includes a framework with a plurality of flap portions projecting substantially beyond a central core region. The flap portions are movable from a compressed position and an extended position when the stent is deployed. The system includes a catheter and the intraluminal stent. The method includes positioning an intraluminal stent within a vessel. A plurality of flap portions of the stent is extended from a compressed position into contact with the vessel.

摘要翻译： 管腔内支架，腔内支架输送系统和治疗血管病变的方法。 支架包括具有大致突出超过中心芯区域的多个翼片部分的框架。 当支架展开时，翼片部分可从压缩位置和伸出位置移动。 该系统包括导管和管腔内支架。 该方法包括将管腔内支架定位在血管内。 支架的多个翼片部分从压缩位置延伸以与血管接触。

公开(公告)号：US07912539B2

公开(公告)日：2011-03-22

申请号：US12363872

申请日：2009-02-02

申请人： David Doty ,  Feridun Ozdil ,  Josiah Wilcox ,  Robret Murray ,  Prasad Kilari

发明人： David Doty ,  Feridun Ozdil ,  Josiah Wilcox ,  Robret Murray ,  Prasad Kilari

IPC分类号： A61N1/30 ,  A61B18/18

CPC分类号： A61B17/12136 ,  A61B17/12045 ,  A61B17/12109 ,  A61B2017/12127 ,  A61B2017/22085 ,  A61M25/1011 ,  A61M2025/09008 ,  A61M2025/1052 ,  A61N5/0601 ,  A61N5/062

摘要： A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes a catheter having a first inflatable member and a guidewire having a second inflatable member. The catheter has an extended tip distal to the first inflatable member that includes multiple perfusion ports. A light emission coil is disposed on the extended tip with individual coil loops interspaced with the perfusion ports. In a method, the guidewire is delivered to a treatment site within a vessel. The catheter is delivered to the treatment site over the guidewire. The inflatable members are inflated to form an enclosed treatment space within the vessel. A photoinitiator is delivered to the enclosed treatment space. Excess photoinitiator is flushed from the treatment space, and a prepolymer is delivered. The prepolymer is cured by light delivered by the light emission coil.

摘要翻译： 通过光聚合将聚合物（水凝胶）施加到容器的内表面的系统包括具有第一可充气构件和具有第二可充气构件的导丝的导管。 导管具有远离第一可充气构件的延伸尖端，其包括多个灌注端口。 发光线圈设置在延伸尖端上，其中单个线圈环与灌注端口间隔开。 在一种方法中，将导丝输送到血管内的治疗部位。 导管通过导丝输送到治疗部位。 充气构件被充气以在容器内形成封闭的处理空间。 光引发剂被输送到封闭的处理空间。 从处理空间冲洗过量的光引发剂，并递送预聚物。 预聚物由发光线圈输送的光固化。

公开(公告)号：US07515957B2

公开(公告)日：2009-04-07

申请号：US11166850

申请日：2005-06-23

申请人： David Doty ,  Feridun Ozdil ,  Josiah Wilcox ,  Robret Murray ,  Prasad Kilari

发明人： David Doty ,  Feridun Ozdil ,  Josiah Wilcox ,  Robret Murray ,  Prasad Kilari

IPC分类号： A61N1/30 ,  A61B18/18

CPC分类号： A61B17/12136 ,  A61B17/12045 ,  A61B17/12109 ,  A61B2017/12127 ,  A61B2017/22085 ,  A61M25/1011 ,  A61M2025/09008 ,  A61M2025/1052 ,  A61N5/0601 ,  A61N5/062

摘要： A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes a catheter having a first inflatable member and a guidewire having a second inflatable member. The catheter has an extended tip distal to the first inflatable member that includes multiple perfusion ports. A light emission coil is disposed on the extended tip with individual coil loops interspaced with the perfusion ports. In a method, the guidewire is delivered to a treatment site within a vessel. The catheter is delivered to the treatment site over the guidewire. The inflatable members are inflated to form an enclosed treatment space within the vessel. A photoinitiator is delivered to the enclosed treatment space. Excess photoinitiator is flushed from the treatment space, and a prepolymer is delivered. The prepolymer is cured by light delivered by the light emission coil.

摘要翻译： 通过光聚合将聚合物（水凝胶）施加到容器的内表面的系统包括具有第一可充气构件和具有第二可充气构件的导丝的导管。 导管具有远离第一可充气构件的延伸尖端，其包括多个灌注端口。 发光线圈设置在延伸尖端上，其中单个线圈环与灌注端口间隔开。 在一种方法中，将导丝输送到血管内的治疗部位。 导管通过导丝输送到治疗部位。 充气构件被充气以在容器内形成封闭的处理空间。 光引发剂被输送到封闭的处理空间。 从处理空间冲洗过量的光引发剂，并递送预聚物。 预聚物由发光线圈输送的光固化。

公开(公告)号：US20090024209A1

公开(公告)日：2009-01-22

申请号：US11780702

申请日：2007-07-20

申请人： Feridun Ozdil ,  Joseph Berglund

发明人： Feridun Ozdil ,  Joseph Berglund

IPC分类号： A61F2/06

CPC分类号： A61F2/88 ,  A61F2210/0004 ,  A61F2250/003 ,  A61F2250/0035 ,  A61F2250/0068

摘要： An implantable device capable of delivering drugs is disclosed. An example of the device is a stent that comprises at least one hypotube having a lumen and one or more pores. The lumen of the hypotube is configured to retain drugs that can be eluted through the one or more pores after deployment at a treatment site.

摘要翻译： 公开了一种能够输送药物的可植入装置。 该装置的实例是包括至少一个具有内腔和一个或多个孔的海波管的支架。 海波管的管腔被配置为保留在处置部位展开后可以通过一个或多个孔洗脱的药物。