公开(公告)号：US20060058245A1

公开(公告)日：2006-03-16

申请号：US11211369

申请日：2005-08-24

申请人： Brian Day ,  Richard Sawyer ,  Lee Newman

发明人： Brian Day ,  Richard Sawyer ,  Lee Newman

IPC分类号： A61K31/7048 ,  A61K31/655 ,  A61K31/537 ,  A61K31/353 ,  A61K31/366 ,  A61K31/47

CPC分类号： A61K31/635 ,  A61K31/35 ,  A61K31/353 ,  A61K31/37 ,  A61K31/428 ,  A61K31/47 ,  A61K31/60 ,  A61K31/606 ,  A61K2121/00

摘要： Methods for therapy of cystic fibrosis and other conditions are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis and/or another condition responsive to stimulation of thiol-containing compound transport.

公开(公告)号：US20070014723A1

公开(公告)日：2007-01-18

申请号：US11486682

申请日：2006-07-14

申请人： Richard Sawyer ,  Brian Day ,  Lee Newman

发明人： Richard Sawyer ,  Brian Day ,  Lee Newman

IPC分类号： A61K51/00

CPC分类号： A61K51/08

摘要： The present invention concerns methods and compositions for making and using Be complexes of defined compositions, which may have multiple functionalities and/or binding specificities. In various embodiment, Beryllium (Be) complexes may include Be such as 10Be and 7Be complexes. Such complexes find use in a wide variety of applications, particularly in the field of treatment, detection and/or diagnosis of infections, diseases and other health-related conditions, including but not limited to cancer, autoimmune disease, cardiovascular disease, metabolic diseases, degenerative diseases, and organ transplant rejection. In addition, a Be complex may be used in a BeLPT assay

摘要翻译： 本发明涉及用于制备和使用具有多种功能和/或结合特异性的限定组合物的Be复合物的方法和组合物。 在各种实施方案中，铍（Be）络合物可以包括Be，例如Be和Be7+配合物。 这样的复合物可用于各种各样的应用，特别是在治疗，检测和/或诊断感染，疾病和其它健康相关病症的领域中，包括但不限于癌症，自身免疫性疾病，心血管疾病，代谢疾病， 退行性疾病和器官移植排斥反应。 此外，Be络合物可用于BeLPT测定

公开(公告)号：US20190300406A1

公开(公告)日：2019-10-03

申请号：US16374062

申请日：2019-04-03

申请人： Scott Wolcott ,  Lee Newman ,  Peter Martin ,  Joshua Goldowitz

发明人： Scott Wolcott ,  Lee Newman ,  Peter Martin ,  Joshua Goldowitz

IPC分类号： C02F3/10 ,  C02F3/32

摘要： A wastewater treatment system, including: an equalization tank arranged to receive wastewater; a flow tube including an interior space bounded by at least one side wall of the flow tube; a plurality of media particles disposed within the interior space; and a pump arranged to pump the wastewater from the equalization tank to the flow tube. The plurality of media particles has a mean diameter of at least 4 millimeters. The wastewater is arranged to drain to the equalization tank through the plurality of media particles and the interior space. The flow tube is arranged to reduce a concentration of an organic contaminant in the wastewater.

公开(公告)号：US10645934B2

公开(公告)日：2020-05-12

申请号：US13634135

申请日：2011-03-10

申请人： Lee Newman ,  Daniel van der Lelie ,  Safiyh Taghavi

发明人： Lee Newman ,  Daniel van der Lelie ,  Safiyh Taghavi

IPC分类号： A01N63/00 ,  C12R1/01 ,  C12N1/20 ,  A01N63/10

摘要： The present invention relates to a novel species of Enterobacter, Enterobacter sp. 638, and to its use in connection, for example, with a method for increasing growth in a plant, increasing biomass in a plant, increasing fruit and/or seed productivity in a plant, increasing disease tolerance and/or resistance in a plant, and increasing drought tolerance and/or resistance in a plant, as compared to a control or wild-type plant grown under identical conditions without application of the inventive method or composition. The methods include applying an effective amount of a composition, which includes an isolated culture of Enterobacter sp. 638, to the plant.

公开(公告)号：US20060263761A1

公开(公告)日：2006-11-23

申请号：US11373581

申请日：2006-03-10

申请人： Andrew Fontenot ,  Brian Kotzin ,  Lee Newman ,  Lisa Maier

发明人： Andrew Fontenot ,  Brian Kotzin ,  Lee Newman ,  Lisa Maier

IPC分类号： C12Q1/00 ,  G01N33/567 ,  G01N33/20

CPC分类号： G01N33/6863 ,  G01N33/56972 ,  G01N2800/12 ,  G01N2800/24

摘要： The present invention provides for methods for detection, diagnosis and prognosis of beryllium-induced disease. In one embodiment, the methods include exposing immune cells from subjects suspected of having beryllium-induced disease to beryllium and assessing the Th-1 cytokines produced. Other embodiments include the use of exposing immune cells from subjects suspected of having beryllium-induced disease to beryllium and assessing Th-1 cytokines produced and using these assessments to indicate the stage of progression of the disease. Therapeutic methods involve assessing the onset or progression of beryllium-induced disease before during and after exposure to a treatment for the disease.

摘要翻译： 本发明提供了铍诱发疾病的检测，诊断和预后的方法。 在一个实施方案中，所述方法包括将怀疑患有铍诱发疾病的受试者的免疫细胞暴露于铍并评估产生的Th-1细胞因子。 其他实施方案包括将怀疑患有铍诱发疾病的受试者的免疫细胞暴露于铍并评估所产生的Th1细胞因子并使用这些评估来指示疾病进展阶段的用途。 治疗方法包括在暴露于该疾病的治疗之前和之后评估铍诱发的疾病的发作或进展。

公开(公告)号：US10662096B2

公开(公告)日：2020-05-26

申请号：US16374062

申请日：2019-04-03

申请人： Scott Wolcott ,  Lee Newman ,  Peter Martin ,  Joshua Goldowitz

发明人： Scott Wolcott ,  Lee Newman ,  Peter Martin ,  Joshua Goldowitz

IPC分类号： C02F3/10 ,  C02F3/32 ,  C02F101/16 ,  C02F103/00 ,  C02F101/10

摘要： A wastewater treatment system, including: an equalization tank arranged to receive wastewater; a flow tube including an interior space bounded by at least one side wall of the flow tube; a plurality of media particles disposed within the interior space; and a pump arranged to pump the wastewater from the equalization tank to the flow tube. The plurality of media particles has a mean diameter of at least 4 millimeters. The wastewater is arranged to drain to the equalization tank through the plurality of media particles and the interior space. The flow tube is arranged to reduce a concentration of an organic contaminant in the wastewater.

公开(公告)号：US20130150240A1

公开(公告)日：2013-06-13

申请号：US13634135

申请日：2011-03-10

申请人： Lee Newman ,  Daniel van der Lelie ,  Safiyh Taghavi

发明人： Lee Newman ,  Daniel van der Lelie ,  Safiyh Taghavi

IPC分类号： A01N63/00

CPC分类号： A01N63/00 ,  A01N63/02 ,  C12N1/20 ,  C12R1/01 ,  A01N31/02 ,  A01N31/04 ,  A01N35/02 ,  A01N37/40 ,  A01N43/38 ,  A01N63/04

摘要： The present invention relates to a novel species of Enterobacter, Enterobacter sp. 638, and to its use in connection, for example, with a method for increasing growth in a plant, increasing biomass in a plant, increasing fruit and/or seed productivity in a plant, increasing disease tolerance and/or resistance in a plant, and increasing drought tolerance and/or resistance in a plant, as compared to a control or wild-type plant grown under identical conditions without application of the inventive method or composition. The methods include applying an effective amount of a composition, which includes an isolated culture of Enterobacter sp. 638, to the plant.

摘要翻译： 本发明涉及一种新型肠杆菌，肠杆菌属 例如，其用于增加植物生长的方法，增加植物中的生物量，增加植物中的水果和/或种子生产力，增加植物中的耐病性和/或耐药性的方法， 并且与在相同条件下生长的对照或野生型植物相比，在不施用本发明方法或组合物的情况下，植物中耐旱性和/或抗性增加。 所述方法包括施用有效量的组合物，其包括肠杆菌属的分离培养物。 638，到厂。