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1.发明申请Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases 审中-公开苯扎氮平衍生物和预防或治疗5Ht2c受体相关疾病的方法公开(公告)号：US20080009478A1
公开(公告)日：2008-01-10
申请号：US10576849
申请日：2004-10-21
IPC分类号： A61K31/55 , A61P15/00 , A61P25/06 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P3/04 , C07D223/16
CPC分类号： C07D223/16
摘要： The present invention relates to substituted-2,3,4,5-tetrahydro-3-benzazepine derivatives that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the prophylaxis or treatment of 5HT2C receptor associated diseases, conditions or disorders, such as, obesity and related disorders.
摘要翻译： 本发明涉及作为5HT 2C受体的调节剂的取代-2,3,4,5-四氢-3-苯并氮杂衍生物。 因此，本发明的化合物可用于预防或治疗5HT 2C受体相关疾病，病症或障碍，例如肥胖症和相关疾病。
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公开(公告)号：US08946207B2
公开(公告)日：2015-02-03
申请号：US13619773
申请日：2012-09-14
申请人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Ulrich Weigl , Heidedore Jlsabeth Rey-Papina
发明人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl
IPC分类号： A61K31/55 , C07D223/16 , C07C209/50 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C17/16 , C07C25/06 , C07C209/74 , C07C211/27
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
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公开(公告)号：US09102627B2
公开(公告)日：2015-08-11
申请号：US13619788
申请日：2012-09-14
申请人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl , Heidedore Jlsabeth Rey-Papina
发明人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl
IPC分类号： A61K31/55 , C07D223/16 , C07D401/02 , C07D403/02 , C07C209/50 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C17/16 , C07C25/06 , C07C209/74 , C07C211/27
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
摘要翻译： 本发明提供了用于制备3-苯并氮杂及其盐的方法和中间体，其可用作5-羟色胺（5-HT）受体激动剂，用于治疗例如中枢神经系统疾病如肥胖症。
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公开(公告)号：US08367657B2
公开(公告)日：2013-02-05
申请号：US10560953
申请日：2004-06-16
申请人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Ulrich Weigl , Heidedore Jlsabeth Rey-Papina
发明人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl
IPC分类号： A61P25/00 , A61K31/55 , C07D223/00
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
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公开(公告)号：US20130165648A1
公开(公告)日：2013-06-27
申请号：US13619788
申请日：2012-09-14
申请人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl , Heidedore Jlsabeth Rey-Papina
发明人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
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6.发明授权Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases 失效苯扎西平衍生物和预防或治疗5ht2c受体相关疾病的方法公开(公告)号：US07704993B2
公开(公告)日：2010-04-27
申请号：US10561071
申请日：2004-06-16
IPC分类号： A61P25/00 , A61K31/55 , C07D223/16
CPC分类号： A61K31/55 , C07D223/16
摘要： The present invention relates to certain 1-substituted-2,3,4,5-tetrahydro-3-benzazepine derivatives of Formula (I), that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the prophylaxis or treatment of 5HT2C receptor associated diseases, conditions or disorders, such as, obesity and related disorders.
摘要翻译： 本发明涉及式（I）的某些1-取代-2,3,4,5-四氢-3-苯并吖庚因衍生物，其是5HT 2C受体的调节剂。 因此，本发明的化合物可用于预防或治疗5HT 2C受体相关疾病，病症或障碍，如肥胖症和相关疾病。
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7.发明授权Benzazepine derivatives and methods of prophylaxis or treatment of 5HT2C receptor associated diseases 失效苯扎西平衍生物和预防或治疗5HT2C受体相关疾病的方法公开(公告)号：US08404675B2
公开(公告)日：2013-03-26
申请号：US12729026
申请日：2010-03-22
IPC分类号： A61P25/00 , A61K31/55 , C07D223/16
CPC分类号： A61K31/55 , C07D223/16
摘要： The present invention relates to certain 1-substituted-2,3,4,5-tetrahydro-3-benzazepine derivatives of Formula (I), that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the prophylaxis or treatment of 5HT2C receptor associated diseases, conditions or disorders, such as, obesity and related disorders.
摘要翻译： 本发明涉及式（I）的某些1-取代-2,3,4,5-四氢-3-苯并吖庚因衍生物，其是5HT 2C受体的调节剂。 因此，本发明的化合物可用于预防或治疗5HT 2C受体相关疾病，病症或障碍，如肥胖症和相关疾病。
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公开(公告)号：US20080045502A1
公开(公告)日：2008-02-21
申请号：US10560953
申请日：2004-06-16
申请人： Beverly L. Wolgast , Charles A. Gilson , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl
发明人： Beverly L. Wolgast , Charles A. Gilson , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl
IPC分类号： A61K31/55 , A61P3/04 , C07C213/00 , C07C215/28 , C07D223/16
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
摘要翻译： 本发明提供了用于制备3-苯并氮杂及其盐的方法和中间体，其可用作5-羟色胺（5-HT）受体激动剂，用于治疗例如中枢神经系统疾病如肥胖症。
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公开(公告)号：US20180110941A1
公开(公告)日：2018-04-26
申请号：US15476932
申请日：2017-03-31
申请人： Brian Smith , John Michael Kasha
发明人： Brian Smith , John Michael Kasha
CPC分类号： A61M15/004 , A61M11/042 , A61M15/0021 , A61M15/003 , A61M15/0036 , A61M15/0066 , A61M2205/276 , A61M2205/3358 , A61M2205/3368 , A61M2205/3561 , A61M2205/3584 , A61M2205/50 , A61M2205/6009 , A61M2205/609 , A61M2205/8206 , A61M2205/8237
摘要： A medicine dosing device for vaporizing a dose of encapsulated liquid medicine inhaling includes a housing with vapor passage between an intake and a mouthpiece. A tank assembly receives the capsule with a closure member pressing the capsule against a needle and spring assembly to puncture the capsule with a hollow needle and press the liquid from the capsule into a tank chamber where is it wicked into the vapor passageway for vaporization. A heater coil between the mouthpiece and the vaporizing wick heats the vaporized medicine before inhalation by the user. A controller having a processor, power management, temperature control, communications and security subsystems enable the medicine dosing device to be enable for use, controlled and monitored remotely with a mobile device.
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公开(公告)号：US08993750B2
公开(公告)日：2015-03-31
申请号：US14326977
申请日：2014-07-09
申请人： Brian Smith , Jeffrey Smith
发明人： Brian Smith , Jeffrey Smith
IPC分类号： C07D223/16 , C07D403/14
CPC分类号： A61K31/55 , A61K9/20 , C07D223/16 , C07D403/04 , C07D409/04 , C07D491/04
摘要： The present invention relates to novel compounds of Formula (I): which act as 5HT2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity.
摘要翻译： 本发明涉及新的式（I）化合物：其作为5HT 2C受体调节剂。 这些化合物可用于药物组合物，其用途包括治疗肥胖症。
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