摘要:
The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.
摘要:
The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.
摘要:
The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.
摘要:
The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
摘要:
Fixed frequency, fixed duration pulse streams are used to control power switches for one or more electrical motors of electrically powered vehicles or hybrid vehicles having one or more electric motors. The advantages of a pulse system are increased power efficiency and system simplicity over analog systems. The capability of system calibration with a single pulse allows the system to be used under any conditions, and real time adaptation to changes in conditions. Such system and methods provide much improved acceleration over other electrical systems, by making the best use of the coefficient of starting or static friction. The systems and methods provide a non slip traction control system, and the use of an off state in the pulse stream is superior to the use of braking systems for the same purpose, which waste power and cause mechanical wear. In addition, related computer program products are described.
摘要:
Disclosed are lighting techniques, including systems, apparatus, and methods, that employ optical transmission of two-dimensional control signals to manipulate lighting elements. The lighting apparatus can include a projector with an IR LED array to wirelessly transmit pixel information onto a target space. The pixel information controls lighting elements within the target space. The two-dimensional control signals can includes subareas corresponding to lighting elements in a control array. The lighting elements can be lights of desired wavelengths including infrared and/or visible wavelengths. LEDs can be used as light sources in exemplary embodiments.
摘要:
The invention encompasses methods and compositions for increasing or decreasing collagen 1A1 expression and/or α-smooth muscle actin expression in lung fibroblasts using SERPINE2 and antagonists of SERPINE2. The invention also encompasses methods and compositions for increasing or decreasing the formation of myofibroblasts. The invention further provides methods and compositions for treatment of lung diseases, such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.
摘要:
The present invention relates to regulation of inflammation. More particularly, the present invention is directed to nucleic acids encoding components of the ubiquitin ligation pathway, e.g., ubiquitin and ubiquitin-like molecules, E1, E2, and E3 proteins and their substrates, which are involved in modulation of the inflammatory process. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate the inflammatory process via modulation of the ubiquitin ligation pathway; as well as to the use of expression profiles and compositions in diagnosis and therapy related to regulation of inflammation and modulation of cytokine signaling involved in inflammation, e.g., for treatment of infection, autoimmune disease and other diseases related to the inflammatory process.
摘要:
A switched preconditioner circuit is provided at the power input end of a light source to effectively drop the voltage of the light source to zero volts whenever the light source is required to be in an OFF state thereby eliminating the problem of unwanted current through the light source. The preconditioner circuit may include a terminal connected to a first power potential, a terminal connected to a power node at the power input end of the light source, and an input to receive a preconditioner control signal to place the preconditioner circuit in one of an ON state and an OFF state. The preconditioner circuit supplies the voltage to the power node in its ON state and effectively eliminates the voltage to the power node in its OFF state. The preconditioner circuit also may include a bleed path connected between the power node and a second or ground potential to shunt all power supplied to the power node when the preconditioner circuit input receives a signal to place the preconditioner circuit in the OFF state.
摘要:
A switched preconditioner circuit is provided at the power input end of a light source to effectively drop the voltage of the light source to zero volts whenever the light source is required to be in an OFF state thereby eliminating the problem of unwanted current through the light source. The preconditioner circuit may include a terminal connected to a first power potential, a terminal connected to a power node at the power input end of the light source, and an input to receive a preconditioner control signal to place the preconditioner circuit in one of an ON state and an OFF state. The preconditioner circuit supplies the voltage to the power node in its ON state and effectively eliminates the voltage to the power node in its OFF state. The preconditioner circuit also may include a bleed path connected between the power node and a second or ground potential to shunt all power supplied to the power node when the preconditioner circuit input receives a signal to place the preconditioner circuit in the OFF state.