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公开(公告)号:US11358988B2
公开(公告)日:2022-06-14
申请号:US16711105
申请日:2019-12-11
发明人: Kevin W. Gillman , Jason Goodrich , Kenneth M. Boy , Yunhui Zhang , Claudio Mapelli , Michael A. Poss , Paul Michael Scola , David R. Langley , Nicholas A. Meanwell
摘要: The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
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公开(公告)号:US11180474B2
公开(公告)日:2021-11-23
申请号:US16321616
申请日:2017-07-27
发明人: Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , Tasir S. Haque , Michael A. Poss , Louis J. Lombardo , John E. Macor , Laxman Pasunoori , Sreekantha Ratna Kumar
IPC分类号: C07D401/14 , C07D405/14 , C07D417/14 , C07D451/02 , C07D401/04 , C07D413/14 , A61P37/06 , C07D409/14
摘要: Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号:US10053454B2
公开(公告)日:2018-08-21
申请号:US14770230
申请日:2014-02-27
发明人: Michael A. Poss , David R. Tortolani , Ashok Vinayak Purandare , John S. Tokarski , Christopher P. Mussari , Muthoni G. Kamau , Dharmpal S. Dodd , Ashvinikumar V. Gavai , Daniel O'Malley , Tram N. Huynh , Wayne Vaccaro , Lalgudi S. Harikrishnan
IPC分类号: C07D413/04 , C07D413/10 , C07D413/14 , C07D417/14 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/553
CPC分类号: C07D413/10 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/553 , C07D413/04 , C07D413/14 , C07D417/14
摘要: The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号:US20140256700A1
公开(公告)日:2014-09-11
申请号:US14190477
申请日:2014-02-26
发明人: Michael A. Poss , David R. Tortolani , Dharmpal S. Dodd , Christopher P. Mussari , John S. Tokarski , Ashvinikumar V. Gavai , Yufen Zhao , George V. Delucca , Daniel O'Malley , Derek J. Norris , Patrice Gill , Claude A. Quesnelle , Wen-Ching Han
IPC分类号: A61K31/553 , A61K31/5377 , C07D417/14 , C07D413/14 , A61K31/422 , A61K31/4192 , A61K31/496 , A61K31/427 , A61K31/5355 , A61K31/541 , C07D405/14 , C07D413/04 , A61K31/454
CPC分类号: A61K31/553 , A61K31/4192 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要: The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
摘要翻译: 本发明涉及咔唑化合物,包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号:US10214537B2
公开(公告)日:2019-02-26
申请号:US15521202
申请日:2015-10-21
发明人: Rajeev S. Bhide , Douglas G. Batt , Robert J. Cherney , Lyndon A. M. Cornelius , Qingjie Liu , David Marcoux , James Neels , Michael A. Poss , Zheming Ruan , Qing Shi , Anurag S. Srivastava , Lan-ying Qin , Joseph A. Tino , Scott Hunter Watterson
IPC分类号: C07D487/04 , C07D491/08 , A61K31/53 , A61K31/541 , A61P29/00
摘要: Disclosed are compounds of Formula (I) or a salt thereof; wherein: X is N or CH; Q1 is: (i) Cl, Br, I, —CN, —CH3, or —CF3; (ii) a 5-membered heteroaryl selected from pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, and thiadiazolyl; (iii) a 6?membered heteroaryl selected from pyridinyl, pyridazinyl, and pyrimidinyl; or (iv) a bicyclic heteroaryl selected from indolyl, pyrrolopyridinyl, pyrazolopyridinyl and benzo[d]oxazolyl; wherein each of said 5-membered, 6-membered, and bicyclic heteroaryl is substituted with zero to 1 Ra and zero to 1 Rb; and R1, R2, R3, R4, R5, R6, Ra, and Rb are defined herein. Also disclosed are methods of using such compounds as modulators of PI3K, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases.
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公开(公告)号:US20170355707A1
公开(公告)日:2017-12-14
申请号:US15521202
申请日:2015-10-21
发明人: Rajeev S. Bhide , Douglas G. Batt , Robert J Cherney , Lyndon A.M. Cornelius , Qingjie Liu , David Marcoux , James Neels , Michael A. Poss , Zheming Ruan , Qing Shi , Anurag S. Srivastava , Lan-ying Qin , Joseph A. Tino , Scott Hunter Watterson
IPC分类号: C07D491/08 , C07D487/04
CPC分类号: C07D491/08 , C07D487/04
摘要: Disclosed are compounds of Formula (I) or a salt thereof; wherein: X is N or CH; Q1 is: (i) Cl, Br, I, —CN, —CH3, or —CF3; (ii) a 5-membered heteroaryl selected from pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, and thiadiazolyl; (iii) a 6?membered heteroaryl selected from pyridinyl, pyridazinyl, and pyrimidinyl; or (iv) a bicyclic heteroaryl selected from indolyl, pyrrolopyridinyl, pyrazolopyridinyl and benzo[d]oxazolyl; wherein each of said 5-membered, 6-membered, and bicyclic heteroaryl is substituted with zero to 1 Ra and zero to 1 Rb; and R1, R2, R3, R4, R5, R6, Ra, and Rb are defined herein. Also disclosed are methods of using such compounds as modulators of PI3K, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases.
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公开(公告)号:US09492460B2
公开(公告)日:2016-11-15
申请号:US14190477
申请日:2014-02-26
发明人: Michael A. Poss , David R. Tortolani , Dharmpal S. Dodd , Christopher P. Mussari , John S. Tokarski , Ashvinikumar V. Gavai , Yufen Zhao , George V. Delucca , Daniel O'Malley , Derek J. Norris , Patrice Gill , Claude A. Quesnelle , Wen-Ching Han
IPC分类号: C07D405/14 , C07D413/14 , C07D417/14 , A61K31/553 , C07D413/04 , A61K31/4192 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5355 , A61K31/5377 , A61K31/541
CPC分类号: A61K31/553 , A61K31/4192 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要: The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
摘要翻译: 本发明涉及咔唑化合物,包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号:US20190262311A1
公开(公告)日:2019-08-29
申请号:US16330964
申请日:2017-09-08
发明人: Alaric J. Dyckman , Dharmpal S. Dodd , Tasir Shamsul Haque , Louis J. Lombardo , John E. Macor , Christopher P. Mussari , Laxman Pasunoori , Michael A. Poss , Sreekantha Ratna Kumar , Shoshana L. Posy , David R. Tortolani , Brian K. Whiteley , Ramesh Kumar Sistla , Subramanya Hegde , Anupama Kandhi Ramachandra Reddy
IPC分类号: A61K31/404 , A61P37/06 , A61P29/00 , A61K9/00
摘要: Disclosed are compounds of Formula (I) N-oxide, or salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号:US20180086793A1
公开(公告)日:2018-03-29
申请号:US15822744
申请日:2017-11-27
发明人: Kevin W. Gillman , Jason Goodrich , Kenneth M. Boy , Yunhui Zhang , Claudio Mapelli , Michael A. Poss , Paul Michael Scola , David R. Langley , Nicholas A. Meanwell
CPC分类号: C07K7/08 , A61K38/00 , A61K38/10 , A61K45/06 , A61K51/088 , C07K7/56 , Y02A50/463
摘要: The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
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公开(公告)号:US20170355698A1
公开(公告)日:2017-12-14
申请号:US15521199
申请日:2015-10-21
发明人: Rajeev S. Bhide , Zheming Ruan , Robert J. Cherney , Lyndon A.M. Cornelius , T.G.Murali Dhar , Hua Gong , David Marcoux , Michael A. Poss , Lan-ying Qin , Qing Shi , Joseph A. Tino
IPC分类号: C07D487/04
CPC分类号: C07D487/04
摘要: Disclosed are compounds of Formula (I); or a salt thereof; wherein Qi is (i) Cl, Br, I, —CN, —CH3, or —CF3; or (ii) pyrazole, triazole, or pyridinyl, each substituted with R1; Q2 is pyridinyl, indazolyl, isoquinolinyl, or benzo[d]imidazolyl substituted with R2 and R3; and R1, R2, and R3 are defined herein. Also disclosed are methods of using such compounds as modulators of PI3K, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases.
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