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1.发明申请ENRICHMENT AND IDENTIFICATION OF FETAL CELLS IN MATERNAL BLOOD AND LIGANDS FOR SUCH USE 有权肝细胞中的细胞增殖和鉴定及其使用配体公开(公告)号：US20130331284A1
公开(公告)日：2013-12-12
申请号：US13883455
申请日：2011-11-09
申请人： Andreas Eckelt , Marie Brinch , Britta Christensen , Ripudaman Singh , Steen Kølvraa , Lotte Hatt
发明人： Andreas Eckelt , Marie Brinch , Britta Christensen , Ripudaman Singh , Steen Kølvraa , Lotte Hatt
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , C12Q1/6806 , C12Q1/6811 , C12Q1/6881 , C12Q2600/156 , G01N33/56966 , G01N2333/4742 , G01N2333/70596
摘要： The present invention relates to enrichment and/or identification of fetal cells of a maternal blood sample using fetal cell specific ligands and/or fetal cell specific hybridization probes wherein the ligand or probes are directed to an endothelial/mesenchymal marker, e.g. CD105, CD146 or CD141, in a first round of enrichment and the ligand or probes, in a second round of enrichment, are directed to an epithelial marker, e.g. a cytokeratin, such as CK7, CK8, CK18 or CK19. Enriched or identified fetal cells may be subjected to steps of detection or diagnosis, wherefore the present invention enables non-invasive 5 prenatal diagnostics.
摘要翻译： 本发明涉及使用胎儿细胞特异性配体和/或胎儿细胞特异性杂交探针对母体血液样品的胎儿细胞的富集和/或鉴定，其中所述配体或探针被引导至内皮/间质标志物，例如， 第一轮浓缩中的CD105，CD146或CD141，以及第二轮富集中的配体或探针，被引导至上皮标志物，例如， 细胞角蛋白，如CK7，CK8，CK18或CK19。 富集或鉴定的胎儿细胞可以经受检测或诊断的步骤，因此本发明能够进行非侵入性的产前诊断。
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2.发明申请ENRICHMENT AND IDENTIFICATION OF FETAL CELLS IN MATERNAL BLOOD AND LIGANDS FOR SUCH USE 审中-公开肝细胞中的细胞增殖和鉴定及其使用配体公开(公告)号：US20120003643A1
公开(公告)日：2012-01-05
申请号：US13143598
申请日：2010-01-07
申请人： Britta Christensen , Steen Kølvraa , Andreas Eckelt , Marie Brinch , Ripudaman Singh , Lotte Hatt
发明人： Britta Christensen , Steen Kølvraa , Andreas Eckelt , Marie Brinch , Ripudaman Singh , Lotte Hatt
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： G01N33/56966 , C12Q2600/158 , G01N33/689 , G01N2800/38
摘要： The present invention relates to enrichment and/or identification of fetal cells of a maternal blood sample using fetal cell specific ligands and/or fetal cell specific hybridization probes. Enriched or identified fetal cells may be subjected to steps of detection or diagnosis, wherefore the present invention enables non-invasive prenatal diagnostics.
摘要翻译： 本发明涉及使用胎儿细胞特异性配体和/或胎儿细胞特异性杂交探针富集和/或鉴定母体血液样品的胎儿细胞。 富集或鉴定的胎儿细胞可以经受检测或诊断的步骤，因此本发明能够实现非侵入性产前诊断。
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3.发明授权Enrichment and identification of fetal cells in maternal blood and ligands for such use 有权母体血液和配体中胎儿细胞的丰富和鉴定公开(公告)号：US09429520B2
公开(公告)日：2016-08-30
申请号：US13883455
申请日：2011-11-09
申请人： Andreas Eckelt , Britta Christensen , Steen Kolvraa , Marie Brinch , Ripudaman Singh , Lotte Hatt
发明人： Andreas Eckelt , Britta Christensen , Steen Kolvraa , Marie Brinch , Ripudaman Singh , Lotte Hatt
IPC分类号： C07H21/04 , C12Q1/68 , G01N21/64 , G01N33/569
CPC分类号： G01N21/6486 , C12Q1/6806 , C12Q1/6811 , C12Q1/6881 , C12Q2600/156 , G01N33/56966 , G01N2333/4742 , G01N2333/70596
摘要： The present invention relates to enrichment and/or identification of fetal cells of a maternal blood sample using fetal cell specific ligands and/or fetal cell specific hybridization probes wherein the ligand or probes are directed to an endothelial/mesenchymal marker, e.g. CD105, CD146 or CD141, in a first round of enrichment and the ligand or probes, in a second round of enrichment, are directed to an epithelial marker, e.g. a cytokeratin, such as CK7, CK8, CK18 or CK19. Enriched or identified fetal cells may be subjected to steps of detection or diagnosis, wherefore the present invention enables non-invasive 5 prenatal diagnostics.
摘要翻译： 本发明涉及使用胎儿细胞特异性配体和/或胎儿细胞特异性杂交探针对母体血液样品的胎儿细胞的富集和/或鉴定，其中所述配体或探针被引导至内皮/间质标志物，例如， 第一轮浓缩中的CD105，CD146或CD141，以及第二轮富集中的配体或探针，被引导至上皮标志物，例如， 细胞角蛋白，如CK7，CK8，CK18或CK19。 富集或鉴定的胎儿细胞可以经受检测或诊断的步骤，因此本发明能够进行非侵入性的产前诊断。
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公开(公告)号：US20120070827A1
公开(公告)日：2012-03-22
申请号：US13169922
申请日：2011-06-27
IPC分类号： G01N33/569 , C07K16/28 , C07K14/00 , G01N21/64 , C12Q1/68 , G01N33/82 , C07K1/14 , C07K14/705
CPC分类号： C12Q1/6879 , C12N5/0081 , C12N15/1037 , C12Q1/6806 , C12Q1/6841 , C12Q2600/156 , G01N33/566
摘要： The present application relates to methods for identification of foetal cells and generation and isolation of binding members recognising foetal cells. Said methods may further be used for other purposes relating to characterisation of biological samples and biological antigens. The methods are characterised by the applicability in situations where the interesting objects are present in a limited amount, or where the interesting objects are intermixed with other material, thus the methods are suitable for use in situations where the ratio of the interesting material compared to other material is low. The application discloses methods for use of detecting foetal cells and method of generating/isolating binding members towards antigenic material of low abundancy.
摘要翻译： 本申请涉及用于鉴定胎儿细胞的方法以及识别胎儿细胞的结合成员的产生和分离。 所述方法还可用于与生物样品和生物抗原的表征有关的其它目的。 这些方法的特征在于在感兴趣的对象以有限的量存在的情况下或者有趣的对象与其他材料混合的情况下的适用性，因此该方法适用于将感兴趣的材料与其他材料相比较的情况 材料低 本申请公开了用于检测胎儿细胞的方法以及将结合成员产生/分离成低丰度抗原物质的方法。
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5.发明授权Method of identifying fetal antigens or cell surface markers using phage display technology 有权使用噬菌体展示技术鉴定胎儿抗原或细胞表面标志物的方法公开(公告)号：US08945828B2
公开(公告)日：2015-02-03
申请号：US13169922
申请日：2011-06-27
CPC分类号： C12Q1/6879 , C12N5/0081 , C12N15/1037 , C12Q1/6806 , C12Q1/6841 , C12Q2600/156 , G01N33/566
摘要： The present application relates to methods for identification of foetal cells and generation and isolation of binding members recognizing foetal cells. The methods of the invention may further be used for other purposes relating to characterization of biological samples and biological antigens. The methods are characterized by the applicability in situations where the interesting objects are present in a limited amount, or where the interesting objects are intermixed with other material, thus the methods are suitable for use in situations where the ratio of the interesting material compared to other material is low.
摘要翻译： 本申请涉及用于鉴定胎儿细胞的方法以及识别胎儿细胞的结合成员的产生和分离。 本发明的方法还可用于与生物样品和生物抗原表征有关的其它目的。 这些方法的特征在于在感兴趣的对象以有限的量存在的情况下或者有趣的对象与其他材料混合的情况下的适用性，因此该方法适用于将感兴趣的材料与其他材料相比较的情况 材料低
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公开(公告)号：US20090220933A1
公开(公告)日：2009-09-03
申请号：US12096594
申请日：2006-12-07
CPC分类号： C12Q1/6879 , C12N5/0081 , C12N15/1037 , C12Q1/6806 , C12Q1/6841 , C12Q2600/156 , G01N33/566
摘要： The present application relates to methods for identification of foetal cells and generation and isolation of binding members recognising foetal cells. Said methods may further be used for other purposes relating to characterisation of biological samples and biological antigens. The methods are characterised by the applicability in situations where the interesting objects are present in a limited amount, or where the interesting objects are intermixed with other material, thus the methods are suitable for use in situations where the ratio of the interesting material compared to other material is low. The application discloses methods for use of detecting foetal cells and method of generating/isolating binding members towards antigenic material of low abundancy.
摘要翻译： 本申请涉及用于鉴定胎儿细胞的方法以及识别胎儿细胞的结合成员的产生和分离。 所述方法还可用于与生物样品和生物抗原的表征有关的其它目的。 这些方法的特征在于在感兴趣的对象以有限的量存在的情况下或者有趣的对象与其他材料混合的情况下的适用性，因此该方法适用于将感兴趣的材料与其他材料相比较的情况 材料低 本申请公开了用于检测胎儿细胞的方法以及将结合成员产生/分离成低丰度抗原物质的方法。
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