公开(公告)号：US06689356B1

公开(公告)日：2004-02-10

申请号：US08472053

申请日：1995-06-06

申请人： Eliahu Zlotkin ,  Susumu Maeda ,  Billy Fred McCutchen ,  Bruce D. Hammock ,  Elizabeth Fowler ,  Rama M. Belagaje

发明人： Eliahu Zlotkin ,  Susumu Maeda ,  Billy Fred McCutchen ,  Bruce D. Hammock ,  Elizabeth Fowler ,  Rama M. Belagaje

IPC分类号： A61K4800

CPC分类号： C12N15/86 ,  A01N63/00 ,  A01N63/02 ,  C07K14/43513 ,  C07K14/43522 ,  C07K16/18 ,  C07K2319/035 ,  C07K2319/036 ,  C07K2319/55 ,  C07K2319/735 ,  C12N15/625 ,  C12N15/8286 ,  C12N2710/14143 ,  Y02A40/162

摘要： A recombinant baculovirus is provided with a genetic coding sequence for the production of a foreign protein that is toxic to insects. Preferred are nuclear polyhedrosis viruses, with preferred embodiments having been constructed and expressed in insect cells: BmNPV.AaIT and AcNPV.AaIT. Both embodiments function in insect cells infected therewith so as to have the toxin AaIT (originating from the venom of the scorpion A. australis) secreted. A clone designated (pCIB4223), which contains the Bombyx mori signal sequence fused to the AaIT sequence, has been deposited with the American type culture collection and designated “ATCC 40906.”

摘要翻译： 重组杆状病毒具有用于产生对昆虫有毒的外源蛋白质的遗传编码序列。 优选的是核型多角体病毒，优选的实施方案已在昆虫细胞中构建和表达：BmNPV.AaIT和AcNPV.AaIT。 两个实施方案在其感染的昆虫细胞中起作用，从而具有分泌的毒素AaIT（源自蝎子A.onstralis的毒液）。 指定的含有与AaIT序列融合的家蚕信号序列（pCIB4223）的克隆已经保藏在美国型培养物收集物中并命名为“ATCC 40906”。

公开(公告)号：US06344193B1

公开(公告)日：2002-02-05

申请号：US09206766

申请日：1998-01-15

申请人： Bruce D. Hammock ,  Billy Fred McCutchen

发明人： Bruce D. Hammock ,  Billy Fred McCutchen

IPC分类号： A01N6300

CPC分类号： C12N15/86 ,  A01N63/00 ,  C12N2710/14143 ,  A01N2300/00

摘要： Insect pests can be controlled by treating the pests or their loci with a combination of recombinant virus and organic insecticide. The recombinant virus preferably is a baculovirus. Combinations of recombinant baculovirus with chemical insecticides provide a dose-response in pests, such as insects, that is greater than additive. Preferred treatments of the invention are uses of recombinant baculoviruses that express a foreign protein or toxin, with pyrethroid insecticides. Treatments against pyrethroid resistant pests are especially useful.

摘要翻译： 可以通过用重组病毒和有机杀虫剂的组合处理害虫或其基因座来控制昆虫害虫。 重组病毒优选为杆状病毒。 重组杆状病毒与化学杀虫剂的组合在害虫（如昆虫）中提供大于添加剂的剂量反应。 本发明的优选处理是用拟除虫菊酯杀虫剂表达外源蛋白或毒素的重组杆状病毒的用途。 对拟除虫菊酯抗性害虫的治疗特别有用。

公开(公告)号：US06596271B2

公开(公告)日：2003-07-22

申请号：US09960760

申请日：2001-09-21

申请人： Bruce D. Hammock ,  Billy Fred McCutchen

发明人： Bruce D. Hammock ,  Billy Fred McCutchen

IPC分类号： A01N6300

CPC分类号： A01N63/00 ,  A01N61/00 ,  A01N57/14 ,  A01N53/00 ,  A01N47/24 ,  A01N43/24 ,  A01N29/12 ,  A01N2300/00

摘要： Insect pests can be controlled by treating the pests or their loci with a combination of recombinant virus and organic insecticide. The recombinant virus preferably is a baculovirus. Combinations of recombinant baculovirus with chemical insecticides provide a dose-response in pests, such as insects, that is greater than additive. Preferred treatments of the invention are uses of recombinant baculoviruses that express a foreign protein or toxin, with pyrethroid insecticides. Treatments against pyrethroid resistant pests are especially useful.

公开(公告)号：US20120245339A1

公开(公告)日：2012-09-27

申请号：US13489008

申请日：2012-06-05

申请人： Linda A. Castle ,  Dan Siehl ,  Lorraine Giver ,  Jeremy Minshull ,  Christina Ivy ,  Yong Hong Chen ,  Phillip A. Patten ,  Rebecca Gorton ,  Nicholas B. Duck ,  Billy Fred McCutchen ,  Roger Kemble

发明人： Linda A. Castle ,  Dan Siehl ,  Lorraine Giver ,  Jeremy Minshull ,  Christina Ivy ,  Yong Hong Chen ,  Phillip A. Patten ,  Rebecca Gorton ,  Nicholas B. Duck ,  Billy Fred McCutchen ,  Roger Kemble

IPC分类号： C12N15/54

CPC分类号： C12N9/1029 ,  C12N15/8275

摘要： Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.

公开(公告)号：US20120122686A1

公开(公告)日：2012-05-17

申请号：US13299788

申请日：2011-11-18

申请人： Linda A. Castle ,  Dan Siehl ,  Lorraine Giver ,  Jeremy Minshull ,  Christina Ivy ,  Yong Hong Chen ,  Phillip A. Patten ,  Rebecca Gorton ,  Nicholas B. Duck ,  Billy Fred McCutchen ,  Roger Kemble

发明人： Linda A. Castle ,  Dan Siehl ,  Lorraine Giver ,  Jeremy Minshull ,  Christina Ivy ,  Yong Hong Chen ,  Phillip A. Patten ,  Rebecca Gorton ,  Nicholas B. Duck ,  Billy Fred McCutchen ,  Roger Kemble

IPC分类号： A01N57/20 ,  A01P13/02 ,  A01H5/00 ,  C12N5/04 ,  C12N5/10 ,  A01H5/10

CPC分类号： C12N15/8275 ,  C12N9/1029 ,  C12N9/1092 ,  C12N15/8209 ,  C12Y205/01019

摘要： Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.

摘要翻译： 本文提供了新的蛋白质，包括能够催化草甘膦和其他结构相关蛋白质的乙酰化的蛋白质。 还提供了能够编码这些蛋白质的新型多核苷酸，包含这些新蛋白质和/或多核苷酸中的一种或多种的组合物，包含这些新化合物的重组细胞和转基因植物，涉及新化合物的多样化方法，以及使用该化合物的方法。 本文提供的一些新颖的方法和化合物可以用于产生对草甘膦有抗性的生物，如植物。

公开(公告)号：US20100240059A1

公开(公告)日：2010-09-23

申请号：US12752509

申请日：2010-04-01

申请人： Timothy K. Chicoine ,  Jeffery W. Derry ,  Christine B. Hazel ,  Nancy L. Henderson ,  David Hondred ,  Deepa Khazi ,  Nancy J. Leysens ,  Donglong Liu ,  Billy Fred McCutchen ,  Wayne J. Mehre ,  Kenneth A. Peeples ,  David W. Saunders ,  Natalie N. Weber ,  Joshua K. Young ,  Cathy Xiaoyan Zhong ,  Gan-Yuan Zhong

发明人： Timothy K. Chicoine ,  Jeffery W. Derry ,  Christine B. Hazel ,  Nancy L. Henderson ,  David Hondred ,  Deepa Khazi ,  Nancy J. Leysens ,  Donglong Liu ,  Billy Fred McCutchen ,  Wayne J. Mehre ,  Kenneth A. Peeples ,  David W. Saunders ,  Natalie N. Weber ,  Joshua K. Young ,  Cathy Xiaoyan Zhong ,  Gan-Yuan Zhong

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12N15/8275

摘要： Compositions and methods related to transgenic glyphosate/ALS inhibitor-tolerant maize plants are provided. Specifically, the present invention provides maize plants having a DP-098140-6 event which imparts tolerance to glyphosate and at least one ALS-inhibiting herbicide. The maize plant harboring the DP-098140-6 event at the recited chromosomal location comprises genomic/transgene junctions having at least the polynucleotide sequence of SEQ ID NO:5 and/or 6. The characterization of the genomic insertion site of the DP-098140-6 event provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the maize DP-098140-6 events are provided.

摘要翻译： 提供了与转基因草甘膦/ ALS抑制剂耐受性玉米植物相关的组合物和方法。 具体地说，本发明提供具有赋予草甘膦耐受性的DP-098140-6事件的玉米植物和至少一种抑制ALS的除草剂。 携带所述染色体位置的DP-098140-6事件的玉米植物包含至少具有SEQ ID NO：5和/或6的多核苷酸序列的基因组/转基因接头。DP-098140的基因组插入位点的表征 -6事件提供了增强的育种效率，并且能够使用分子标记来跟踪育种种群中的转基因插入物及其后代。 提供了用于识别，检测和使用玉米DP-098140-6事件的各种方法和组合物。

公开(公告)号：US07709702B2

公开(公告)日：2010-05-04

申请号：US11433132

申请日：2006-05-12

申请人： Linda A. Castle ,  Dan Siehl ,  Lorraine Giver ,  Jeremy Minshull ,  Cristina Ivy ,  Yong Hong Chen ,  Nicholas B. Duck ,  Phillip A. Patten ,  Rebecca Gorton ,  Billy Fred McCutchen ,  Roger Kemble

发明人： Linda A. Castle ,  Dan Siehl ,  Lorraine Giver ,  Jeremy Minshull ,  Cristina Ivy ,  Yong Hong Chen ,  Nicholas B. Duck ,  Phillip A. Patten ,  Rebecca Gorton ,  Billy Fred McCutchen ,  Roger Kemble

IPC分类号： C12N15/82 ,  A01H5/00 ,  A01H5/10

CPC分类号： C12N15/8275 ,  C12N9/1029 ,  C12N9/1092 ,  C12N15/8209 ,  C12Y205/01019

摘要： Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.

公开(公告)号：US20090282586A1

公开(公告)日：2009-11-12

申请号：US12416288

申请日：2009-04-01

申请人： Linda A. Castle ,  Dan Sichl ,  Lorraine Giver ,  Jeremy Minshull ,  Cristina Ivy ,  Yong Hong Chen ,  Phillip A. Patten ,  Rebecca Gorton ,  Nicholas B. Duck ,  Billy Fred McCutchen ,  Roger Kemble

发明人： Linda A. Castle ,  Dan Sichl ,  Lorraine Giver ,  Jeremy Minshull ,  Cristina Ivy ,  Yong Hong Chen ,  Phillip A. Patten ,  Rebecca Gorton ,  Nicholas B. Duck ,  Billy Fred McCutchen ,  Roger Kemble

IPC分类号： A01H5/00 ,  C12N5/10 ,  A01N57/18

CPC分类号： C12N15/8275 ,  C12N9/1029 ,  C12N9/1092 ,  C12N15/8209 ,  C12Y205/01019

摘要： Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.

公开(公告)号：US20090025103A1

公开(公告)日：2009-01-22

申请号：US12132492

申请日：2008-06-03

申请人： Carl R. Simmons ,  Pedro A. Navarro Acevedo ,  Leslie Harvell ,  Rebecca Cahoon ,  Billy Fred McCutchen ,  Albert L. Lu ,  Rafael Herrmann ,  James F.H. Wong

发明人： Carl R. Simmons ,  Pedro A. Navarro Acevedo ,  Leslie Harvell ,  Rebecca Cahoon ,  Billy Fred McCutchen ,  Albert L. Lu ,  Rafael Herrmann ,  James F.H. Wong

IPC分类号： C12N15/11 ,  A01H5/00

CPC分类号： C07K14/4723 ,  C07K14/415 ,  C12N15/8279

摘要： Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.

公开(公告)号：US20080241927A1

公开(公告)日：2008-10-02

申请号：US12052868

申请日：2008-03-21

申请人： Linda A. Castle ,  Dan Siehl ,  Lorraine Giver ,  Jeremy Minshull ,  Christina Ivy ,  Yong Hong Chen ,  Phillip A. Patten ,  Rebecca Gorton ,  Nicholas B. Duck ,  Billy Fred McCutchen ,  Roger Kemble

发明人： Linda A. Castle ,  Dan Siehl ,  Lorraine Giver ,  Jeremy Minshull ,  Christina Ivy ,  Yong Hong Chen ,  Phillip A. Patten ,  Rebecca Gorton ,  Nicholas B. Duck ,  Billy Fred McCutchen ,  Roger Kemble

IPC分类号： A01N57/20 ,  C12N5/10 ,  A01P13/00 ,  A01H5/00

CPC分类号： C12N9/1029 ,  C12N15/8275

摘要： Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.

摘要翻译： 本文提供了新的蛋白质，包括能够催化草甘膦和其他结构相关蛋白质的乙酰化的蛋白质。 还提供了能够编码这些蛋白质的新型多核苷酸，包含这些新蛋白质和/或多核苷酸中的一种或多种的组合物，包含这些新化合物的重组细胞和转基因植物，涉及新化合物的多样化方法，以及使用该化合物的方法。 本文提供的一些新颖的方法和化合物可以用于产生对草甘膦有抗性的生物，如植物。