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    Insect control method with genetically engineered biopesticides
    2.
    发明授权
    Insect control method with genetically engineered biopesticides 失效
    基因工程生物农药的昆虫控制方法

    公开(公告)号：US06344193B1

    公开(公告)日：2002-02-05

    申请号：US09206766

    申请日：1998-01-15

    申请人： Bruce D. Hammock ,  Billy Fred McCutchen

    发明人： Bruce D. Hammock ,  Billy Fred McCutchen

    IPC分类号： A01N6300

    CPC分类号： C12N15/86 ,  A01N63/00 ,  C12N2710/14143 ,  A01N2300/00

    摘要： Insect pests can be controlled by treating the pests or their loci with a combination of recombinant virus and organic insecticide. The recombinant virus preferably is a baculovirus. Combinations of recombinant baculovirus with chemical insecticides provide a dose-response in pests, such as insects, that is greater than additive. Preferred treatments of the invention are uses of recombinant baculoviruses that express a foreign protein or toxin, with pyrethroid insecticides. Treatments against pyrethroid resistant pests are especially useful.

    摘要翻译： 可以通过用重组病毒和有机杀虫剂的组合处理害虫或其基因座来控制昆虫害虫。 重组病毒优选为杆状病毒。 重组杆状病毒与化学杀虫剂的组合在害虫（如昆虫）中提供大于添加剂的剂量反应。 本发明的优选处理是用拟除虫菊酯杀虫剂表达外源蛋白或毒素的重组杆状病毒的用途。 对拟除虫菊酯抗性害虫的治疗特别有用。

    Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids
    5.
    发明授权
    Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids 有权
    用可溶性环氧化物水解酶和环氧类别的抑制剂减少肾病

    公开(公告)号：US08513302B2

    公开(公告)日：2013-08-20

    申请号：US13100978

    申请日：2011-05-04

    申请人： Bruce D. Hammock ,  Takaho Watanabe ,  Seung-Jin Ma ,  Susan E. Bennett ,  Judith S. Stern ,  Christophe Morisseau ,  In-Hae Kim

    发明人： Bruce D. Hammock ,  Takaho Watanabe ,  Seung-Jin Ma ,  Susan E. Bennett ,  Judith S. Stern ,  Christophe Morisseau ,  In-Hae Kim

    IPC分类号： A61K31/17 ,  A61K31/16

    CPC分类号： A61K31/70 ,  A61K31/17 ,  A61K31/355

    摘要： The invention provides uses and methods for reducing nephropathy in persons with diabetes mellitus (particularly Type 2 diabetes), in persons with metabolic syndrome, in persons with triglyceride levels over 215 mg/dL, and in persons with a cholesterol level over 200 mg/dL, by administering an inhibitor of soluble epoxide hydrolase (“sEH”). Optionally, a cis-epoxyeicosantrienoic acid (“EET”) can be administered with the sEH inhibitor. The invention further provides for using EETs in conjunction with one or more sEH inhibitors to reduce hypertension, and for compositions of EETs coated with a material insoluble in an acid of pH 3 but soluble in a solution with a pH of 7.4 or higher.

    摘要翻译： 本发明提供了在甘油三酯水平超过215mg / dL的人中以及胆固醇水平超过200mg / dL的人中减少糖尿病患者（特别是2型糖尿病）患有代谢综合征患者的肾病的用途和方法 ，通过施用可溶性环氧化物水解酶（“sEH”）的抑制剂。 任选地，顺式 - 环氧二十碳三烯酸（“EET”）可与sEH抑制剂一起施用。 本发明进一步提供使用EET与一种或多种sEH抑制剂联合以降低高血压，以及用不溶于pH 3但可溶于pH 7.4或更高的溶液的材料涂覆的EET组合物。

    USE OF CIS-EPOXYEICOSATRIENOIC ACIDS AND INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO TREAT CONDITIONS MEDIATED BY PBR, CB2, AND NK2 RECEPTORS
    9.
    发明申请
    USE OF CIS-EPOXYEICOSATRIENOIC ACIDS AND INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO TREAT CONDITIONS MEDIATED BY PBR, CB2, AND NK2 RECEPTORS 有权
    独联体环氧化合物酸和可溶性环氧化物水解酶的抑制剂用于治疗由PBR，CB2和NK2受体介导的病症

    公开(公告)号：US20100074852A1

    公开(公告)日：2010-03-25

    申请号：US12518549

    申请日：2007-01-04

    申请人： Bruce D. Hammock ,  Ahmet Bora Inceoglu

    发明人： Bruce D. Hammock ,  Ahmet Bora Inceoglu

    IPC分类号： A61K31/336 ,  C12N5/00 ,  A61P25/00 ,  A61P1/00

    CPC分类号： A61K31/335 ,  A61K31/17 ,  A61K31/192 ,  A61K31/202 ,  A61K31/336 ,  A61K31/365 ,  A61K31/415 ,  A61K31/60 ,  A61K2300/00

    摘要： The invention relates to the discovery that cis-epoxyeicosatraenoic acids (EETs) bind to and act as agonists of peripheral benzodiazepine receptor and the cannabinoid CB2 receptor. The invention provides methods of reducing symptoms of conditions whose activity is mediated by these receptors, including inhibiting anxiety, inhibiting the growth of cancer cells expressing peripheral benzodiazepine receptors, and reducing oxygen radical damage to cells, by contacting the cells with a cis-epoxyeicosantrienoic acid, an inhibitor of soluble epoxide hydrolase (sEH), or both. The invention further provides methods of inhibiting irritable bowel syndrome by administering to individuals with inhibiting irritable bowel syndrome a cis-epoxyeicosantrienoic acid, an inhibitor of soluble epoxide hydrolase (sEH), or both. In some embodiments, the method comprises administering to the individual a nucleic acid which inhibits expression of sEH.

    摘要翻译： 本发明涉及顺式 - 环氧二十碳四烯酸（EETs）结合并作为外周苯并二氮杂受体和大麻素CB2受体的激动剂的发现。 本发明提供了减少活性由这些受体介导的病症症状的方法，包括抑制焦虑，抑制表达外周苯并二氮杂受体的癌细胞的生长，以及通过使细胞与顺式 - 环氧二十碳三烯酸 ，可溶性环氧化物水解酶（sEH）的抑制剂或两者。 本发明还提供了通过向具有抑制肠易激综合征的个体施用顺式环氧二十碳三烯酸，可溶性环氧化物水解酶（sEH）抑制剂或两者）来抑制肠易激综合征的方法。 在一些实施方案中，该方法包括向个体施用抑制sEH表达的核酸。