公开(公告)号：US20050089471A1

公开(公告)日：2005-04-28

申请号：US10691533

申请日：2003-10-24

申请人： Bruce Johnson ,  Frank Mondello ,  Faisal Syud ,  Andrew Torres ,  John Brogan

发明人： Bruce Johnson ,  Frank Mondello ,  Faisal Syud ,  Andrew Torres ,  John Brogan

IPC分类号： A61K49/00 ,  A61K49/14 ,  A61K49/16 ,  A61K51/10 ,  C07B59/00 ,  A61K51/00 ,  C07F5/00 ,  C07F13/00

CPC分类号： A61K49/0056 ,  A61K49/0002 ,  A61K49/0043 ,  A61K49/0058 ,  A61K49/085 ,  A61K49/14 ,  A61K49/16 ,  A61K51/10 ,  C07B59/008

摘要： Embodiments of the present invention relates to compounds labeled with imaging agents that also are capable of binding lectin-like oxidized low-density lipoprotein (LOX-1). The labeled compounds are useful for the diagnosis and monitoring of diseases in which inflammation plays a role, such as various cardiovascular diseases including but not limited to atherosclerosis, vulnerable plaque, and coronary artery disease, as well as rheumatoid arthritis.

摘要翻译： 本发明的实施方案涉及还能够结合凝集素样氧化低密度脂蛋白（LOX-1）的成像剂标记的化合物。 标记的化合物可用于诊断和监测炎症起作用的疾病，例如各种心血管疾病，包括但不限于动脉粥样硬化，易损斑块和冠状动脉疾病以及类风湿性关节炎。

公开(公告)号：US20070009428A1

公开(公告)日：2007-01-11

申请号：US11175668

申请日：2005-07-06

申请人： Faisal Syud ,  Nichole Wood ,  Andrew Torres ,  Mark Baillie ,  Dinko Trotter ,  Cristina Hehir ,  Ming Zhao ,  Daniel Kramer

发明人： Faisal Syud ,  Nichole Wood ,  Andrew Torres ,  Mark Baillie ,  Dinko Trotter ,  Cristina Hehir ,  Ming Zhao ,  Daniel Kramer

IPC分类号： A61K51/00

CPC分类号： A61K51/04 ,  A61K47/6899 ,  B82Y5/00

摘要： A set of compounds that includes an active-agent labeled species and a pretargeting conjugate is disclosed. The active agent-labeled species includes a ligand coupled to an active agent. The pretargeting conjugate includes a protein conjugated to a targeting species having a targeting moiety capable of binding to an in-vivo target or a biomarker produced by or associated with the target. The protein is substantially free of a cofactor. Also disclosed are methods of administering the pretargeting species and the active-agent labeled species to a subject for diagnosing or treating a disease condition, or assessing the effectiveness of a treatment of the disease condition.

摘要翻译： 公开了一组包含活性剂标记的物质和预靶向缀合物的化合物。 活性剂标记的物质包括与活性剂偶联的配体。 预靶向缀合物包括与靶向物质缀合的蛋白质，其具有能够结合体内靶标的靶向部分或由靶产生或与靶标相关的生物标志物。 蛋白质基本上不含辅因子。 还公开了将预靶向物种和活性剂标记物种施用于受试者以诊断或治疗疾病状况或评估治疗疾病状况的有效性的方法。

公开(公告)号：US20060034761A1

公开(公告)日：2006-02-16

申请号：US10917326

申请日：2004-08-13

申请人： Faisal Syud ,  Ming Zhao ,  Andrew Torres

发明人： Faisal Syud ,  Ming Zhao ,  Andrew Torres

IPC分类号： A61K49/00 ,  C07K14/47

CPC分类号： C07B59/008 ,  A61K49/0002

摘要： The present invention relates to the use of Heat Shock Proteins and fragments thereof as targeting ligand. The Heat Shock Protein may be labeled with imaging agents that are capable of binding lectin-like oxidized low-density lipoprotein (LOX-1) or may be attached to a therapeutic agent. The sequences are useful for the diagnosis and monitoring of diseases as well as means for internalizing signaling moieties and therapeutics.

公开(公告)号：US20070140974A1

公开(公告)日：2007-06-21

申请号：US11304028

申请日：2005-12-15

申请人： Andrew Torres ,  Faisal Syud ,  Nichole Wood ,  Amit Kulkarni ,  Mark Baillie ,  Bahram Moasser ,  Brian Bales ,  Anton Beletskii ,  Peter Bonitatebus

发明人： Andrew Torres ,  Faisal Syud ,  Nichole Wood ,  Amit Kulkarni ,  Mark Baillie ,  Bahram Moasser ,  Brian Bales ,  Anton Beletskii ,  Peter Bonitatebus

IPC分类号： A61K49/10

CPC分类号： A61K49/1848 ,  A61K47/59 ,  A61K47/62 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/1857 ,  A61K49/1866 ,  B82Y5/00 ,  B82Y25/00 ,  G01N33/552 ,  G01R33/5601 ,  H01F1/0054

摘要： In some embodiments, the present invention is directed to novel targeted contrast agents for magnetic resonance imaging (MRI). The present invention is also directed to methods of making such targeted MRI contrast agents, and to methods of using such MRI contrast agents. Typically, such targeted MRI contrast agents provide enhanced relaxivity, improved signal-to-noise, targeting ability, and resistance to agglomeration. Methods of making such MRI contrast agents typically afford better control over particle size, and methods of using such MRI contrast agents typically afford enhanced blood clearance rates and biodistribution.

摘要翻译： 在一些实施方案中，本发明涉及用于磁共振成像（MRI）的新型靶向造影剂。 本发明还涉及制备这种靶向MRI造影剂的方法，以及使用这种MRI造影剂的方法。 通常，这种靶向MRI造影剂提供增强的舒张度，改善的信噪比，靶向能力和抵抗聚集。 制造这种MRI造影剂的方法通常能够更好地控制粒径，并且使用这种MRI造影剂的方法通常提供增强的血液清除率和生物分布。

公开(公告)号：US20070009427A1

公开(公告)日：2007-01-11

申请号：US11175595

申请日：2005-07-06

申请人： Faisal Syud ,  Nichole Wood ,  Andrew Torres ,  Mark Baillie ,  Dinko Eduardo Trotter ,  Cristina Hehir ,  Ming Zhao ,  Daniel Kramer

发明人： Faisal Syud ,  Nichole Wood ,  Andrew Torres ,  Mark Baillie ,  Dinko Eduardo Trotter ,  Cristina Hehir ,  Ming Zhao ,  Daniel Kramer

IPC分类号： A61K51/00

CPC分类号： B82Y5/00 ,  A61K47/6899 ,  A61K51/04

摘要： A set of compounds that includes an active-agent labeled species and a pretargeting conjugate is disclosed. The active agent-labeled species includes a ligand coupled to an active agent. The pretargeting conjugate includes a protein conjugated to a targeting species having a targeting moiety capable of binding to an in-vivo target or a biomarker produced by or associated with the target. The protein and the ligand are covalently attached. Also disclosed are methods of administering the pretargeting species and the active-agent labeled species to a subject for diagnosing or treating a disease condition, or assessing the effectiveness of a treatment of the disease condition.

摘要翻译： 公开了一组包含活性剂标记的物质和预靶向缀合物的化合物。 活性剂标记的物质包括与活性剂偶联的配体。 预靶向缀合物包括与靶向物质缀合的蛋白质，其具有能够结合体内靶标的靶向部分或由靶产生或与靶标相关的生物标志物。 蛋白质和配体共价连接。 还公开了将预靶向物种和活性剂标记物种施用于受试者以诊断或治疗疾病状况或评估治疗疾病状况的有效性的方法。

公开(公告)号：US20070122620A1

公开(公告)日：2007-05-31

申请号：US11627529

申请日：2007-01-26

申请人： Peter Bonitatebus ,  Robert Colborn ,  Amit Kulkarni ,  Andrew Torres ,  Brian Bales ,  Oskar Axelsson

发明人： Peter Bonitatebus ,  Robert Colborn ,  Amit Kulkarni ,  Andrew Torres ,  Brian Bales ,  Oskar Axelsson

IPC分类号： B32B18/00 ,  B32B1/00

CPC分类号： A61K49/0423 ,  B82Y5/00 ,  B82Y30/00 ,  C01G27/02 ,  C01G35/00 ,  C01P2004/04 ,  C01P2004/64 ,  C09C3/12 ,  Y10T428/2991 ,  Y10T428/2993

摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites.

摘要翻译： 本发明通常涉及核/壳纳米颗粒，其中这种核/壳纳米颗粒包含纳米颗粒核和纳米壳，该纳米壳围绕纳米颗粒核设置，使得在聚集体中，它们形成核/壳纳米颗粒，其可操作地用作 X射线/计算机断层摄影（CT）中的成像剂。 通常，这种基于核/壳纳米颗粒的X射线CT成像剂还包含用于将成像剂靶向患病部位的靶向物种。

公开(公告)号：US20070098640A1

公开(公告)日：2007-05-03

申请号：US11265686

申请日：2005-11-02

申请人： Peter Bonitatebus ,  Oskar Axelsson ,  Amit Kulkarni ,  Brian Bales ,  Deborah Walter ,  Andrew Torres ,  Chiaki Treynor

发明人： Peter Bonitatebus ,  Oskar Axelsson ,  Amit Kulkarni ,  Brian Bales ,  Deborah Walter ,  Andrew Torres ,  Chiaki Treynor

IPC分类号： A61K49/04

CPC分类号： C09C1/00 ,  A61K49/0423 ,  B82Y5/00 ,  B82Y30/00 ,  C01G27/02 ,  C01P2004/04 ,  C01P2004/64 ,  C09C1/24 ,  C09C3/08 ,  C09C3/12

摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites.

摘要翻译： 本发明通常涉及核/壳纳米颗粒，其中这种核/壳纳米颗粒包含纳米颗粒核和纳米壳，该纳米壳围绕纳米颗粒核设置，使得在聚集体中，它们形成核/壳纳米颗粒，其可操作地用作 X射线/计算机断层摄影（CT）中的成像剂。 通常，这种基于核/壳纳米颗粒的X射线CT成像剂还包含用于将成像剂靶向患病部位的靶向物种。

公开(公告)号：US20070098642A1

公开(公告)日：2007-05-03

申请号：US11265729

申请日：2005-11-02

申请人： Peter Bonitatebus ,  Oskar Axelsson ,  Amit Kulkarni ,  Brian Bales ,  Deborah Walter ,  Andrew Torres ,  Chiaki Treynor

发明人： Peter Bonitatebus ,  Oskar Axelsson ,  Amit Kulkarni ,  Brian Bales ,  Deborah Walter ,  Andrew Torres ,  Chiaki Treynor

IPC分类号： A61K49/04

CPC分类号： C09C1/00 ,  A61K49/0423 ,  B82Y5/00 ,  B82Y30/00 ,  C01G27/02 ,  C01P2004/04 ,  C01P2004/64 ,  C09C1/24 ,  C09C3/08 ,  C09C3/12

摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites.

公开(公告)号：US20060105052A1

公开(公告)日：2006-05-18

申请号：US10989632

申请日：2004-11-15

申请人： Havva Acar ,  Andrew Torres

发明人： Havva Acar ,  Andrew Torres

IPC分类号： A61K48/00 ,  C12N15/87 ,  A61K9/50

CPC分类号： A61K9/5115 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/1848 ,  A61K49/1851 ,  B82Y5/00

摘要： A cationic nanoparticle having an inorganic core and at least one outer cationic coating is described. The at least one outer cationic coating substantially covers the inorganic core and has at least one organo-silane. The organo-silane includes: —Si(R1)3 wherein R1independently at each occurrence is an alkoxy group, a hydroxyl group, a halide, an alkyl group, or hydrogen, and wherein at least one R1 of the three R1s is not an alkyl group. A nanocomplex having a cationic nanoparticle and at least one oligonucleotide attached to the cationic nanoparticle is also described. Methods of making cationic nanoparticles and nanocomplexes are also described. Also described are methods of delivering an oligonucleotide into a cell in-vitro, to a subject in-vivo, and monitoring the delivery of an oligonucleotide.

摘要翻译： 描述了具有无机核和至少一个外部阳离子涂层的阳离子纳米颗粒。 所述至少一种外部阳离子涂层基本上覆盖所述无机芯并且具有至少一种有机硅烷。 有机硅烷包括：<？in-line-formula description =“In-line Formulas”end =“lead”→Si（R 1）3 < 在线公式描述=“在线公式”end =“tail”？>其中R 1在每次出现时独立地是烷氧基，羟基，卤素，烷基 或氢，并且其中三个R 1的至少一个R 1不是烷基。 还描述了具有阳离子纳米颗粒和连接至阳离子纳米颗粒的至少一个寡核苷酸的纳米复合物。 还描述了制备阳离子纳米颗粒和纳米复合物的方法。 还描述了在体内将寡核苷酸递送到细胞体内的方法，并监测寡核苷酸的递送。

公开(公告)号：US20050273274A1

公开(公告)日：2005-12-08

申请号：US10858744

申请日：2004-06-02

申请人： Scott Evans ,  Stephen Bush ,  Andrew Torres

发明人： Scott Evans ,  Stephen Bush ,  Andrew Torres

IPC分类号： G01N33/48 ,  G01N33/50 ,  G06F17/30 ,  G06F19/00

CPC分类号： G16B30/00

摘要： The present technique provides for the analysis of a data series to identify sequences of interest within the series. The analysis may be used to iteratively update a grammar used to analyze the data series or updated versions of the data series. Furthermore, the technique provides for the calculation of a minimum description length heuristic, such as a symbol compression ratio, for each sub-sequence of the analyzed data sequence. The technique may then compare a selected heuristic value against one or more reference conditions to determine if additional iteration is to be performed. The grammar and the data sequence may be updated between iterations to include a symbol representing a string corresponding to the selected heuristic value based upon a non-termination result of the comparison. Alternatively, the string corresponding to the selected heuristic value may be identified as a sequence of interest based upon a termination result of the comparison.

摘要翻译： 本技术提供数据序列的分析以识别该系列内的感兴趣序列。 该分析可用于迭代地更新用于分析数据系列或数据系列的更新版本的语法。 此外，该技术提供了对分析数据序列的每个子序列的最小描述长度启发式计算，例如符号压缩比。 然后，技术可以将所选择的启发式值与一个或多个参考条件进行比较，以确定是否要执行附加迭代。 可以在迭代之间更新语法和数据序列，以基于比较的非终止结果来包括表示对应于所选择的启发式值的字符串的符号。 或者，可以基于比较的终止结果将对应于所选择的启发式值的字符串识别为感兴趣的序列。