公开(公告)号：US20050089471A1

公开(公告)日：2005-04-28

申请号：US10691533

申请日：2003-10-24

申请人： Bruce Johnson ,  Frank Mondello ,  Faisal Syud ,  Andrew Torres ,  John Brogan

发明人： Bruce Johnson ,  Frank Mondello ,  Faisal Syud ,  Andrew Torres ,  John Brogan

IPC分类号： A61K49/00 ,  A61K49/14 ,  A61K49/16 ,  A61K51/10 ,  C07B59/00 ,  A61K51/00 ,  C07F5/00 ,  C07F13/00

CPC分类号： A61K49/0056 ,  A61K49/0002 ,  A61K49/0043 ,  A61K49/0058 ,  A61K49/085 ,  A61K49/14 ,  A61K49/16 ,  A61K51/10 ,  C07B59/008

摘要： Embodiments of the present invention relates to compounds labeled with imaging agents that also are capable of binding lectin-like oxidized low-density lipoprotein (LOX-1). The labeled compounds are useful for the diagnosis and monitoring of diseases in which inflammation plays a role, such as various cardiovascular diseases including but not limited to atherosclerosis, vulnerable plaque, and coronary artery disease, as well as rheumatoid arthritis.

摘要翻译： 本发明的实施方案涉及还能够结合凝集素样氧化低密度脂蛋白（LOX-1）的成像剂标记的化合物。 标记的化合物可用于诊断和监测炎症起作用的疾病，例如各种心血管疾病，包括但不限于动脉粥样硬化，易损斑块和冠状动脉疾病以及类风湿性关节炎。

公开(公告)号：US20060074231A1

公开(公告)日：2006-04-06

申请号：US10957220

申请日：2004-10-04

申请人： Tiberiu Siclovan ,  Faisal Syud ,  Bruce Johnson

发明人： Tiberiu Siclovan ,  Faisal Syud ,  Bruce Johnson

IPC分类号： C07K14/00 ,  C07D209/18 ,  C07H21/04 ,  C07C227/16

CPC分类号： C07H21/04

摘要： A method of labeling amino acid-containing compounds and derivatives thereof with a halide moiety comprises reacting a nucleophilic moiety on such compounds with a halogenated electrophilic compound. Radioactive halide-labeled amino acid-containing compounds can be targeted to diseased sites and provide a means to diagnose and/or treat the disease.

摘要翻译： 用卤化物部分标记含氨基酸的化合物及其衍生物的方法包括使这些化合物上的亲核部分与卤代亲电子化合物反应。 放射性卤化物标记的含氨基酸的化合物可以靶向病变部位，并提供诊断和/或治疗疾病的手段。

公开(公告)号：US20050089470A1

公开(公告)日：2005-04-28

申请号：US10691532

申请日：2003-10-24

申请人： Bruce Johnson ,  Faisal Syud

发明人： Bruce Johnson ,  Faisal Syud

IPC分类号： A61K49/00 ,  C07B59/00 ,  A61K51/00 ,  C07F5/00

CPC分类号： A61K49/0002 ,  C07B59/008

摘要： The present invention relates to compounds labeled with imaging agents that also are capable of binding lectin-like oxidized low-density lipoprotein (LOX-1). The labeled compounds are useful for the diagnosis and monitoring of diseases in which inflammation plays a role, such as various cardiovascular diseases including but not limited to atherosclerosis, vulnerable plaque and coronary artery disease, as well as rheumatoid arthritis.

摘要翻译： 本发明涉及也能够结合凝集素样氧化低密度脂蛋白（LOX-1）的成像剂标记的化合物。 标记的化合物可用于诊断和监测炎症起作用的疾病，例如各种心血管疾病，包括但不限于动脉粥样硬化，易损斑块和冠状动脉疾病以及类风湿性关节炎。

公开(公告)号：USD1022049S1

公开(公告)日：2024-04-09

申请号：US29831471

申请日：2022-03-21

申请人： Bruce Johnson

设计人： Bruce Johnson

摘要： FIG. 1 is a front perspective view of the box lid stand in an assembled state, showing my design;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a top view thereof;
FIG. 5 is bottom view thereof;
FIG. 6 is a left-side view thereof;
FIG. 7 is a right-side view thereof;
FIG. 8 is a front view thereof in a disassembled state; and,
FIG. 9 is a front perspective view thereof, in an environment of use.
The dash-dash broken lines showing a box lid in FIG. 9 depict environmental subject matter and form no part of the claimed design. The appearance of any portion of the box lid stand shown between break lines forms no part of the claimed design. The dot-dash-dot broken lines depicting the boundary of the box lid stand form no part of the claimed design. All other dash-dash broken lines show portions of the box lid stand that form no part of the claimed design.

公开(公告)号：US20230049174A1

公开(公告)日：2023-02-16

申请号：US17889150

申请日：2022-08-16

申请人： Bruce Johnson

发明人： Bruce Johnson

IPC分类号： A61B10/00

摘要： A method for sample encapsulation. A first sampling swab is provided that includes an absorbent portion and a fluid control portion that extends from the absorbent portion. The absorbent portion is proximate a proximal end of the first sampling swab. The fluid control portion is proximate a distal end of the first sampling swab. A sample is collected with the absorbent portion. At least a portion of the sample is liquid. An encapsulation material is provided that includes a first web and a second web. The first sampling swab is positioned between the first web and the second web. The first web is urged into contact with the second web proximate the absorbent portion. The urging of the first web into contact with the second web proximate the absorbent portion causes liquid to move from the absorbent portion towards the fluid control portion. The urging of the first web into contact with the second web proximate the absorbent portion is discontinued which causes the liquid to be drawn into the absorbent portion. The first web is urged into contact with the second web proximate the distal end of the first sampling swab to encapsulate the liquid in the encapsulation material.

公开(公告)号：USD938823S1

公开(公告)日：2021-12-21

申请号：US29762887

申请日：2020-12-18

申请人： Bruce Johnson

设计人： Bruce Johnson

公开(公告)号：US20190262167A1

公开(公告)日：2019-08-29

申请号：US16407898

申请日：2019-05-09

申请人： Liney Guidry ,  Theresa Johnson ,  Reed Johnson ,  Bruce Johnson

发明人： Liney Guidry ,  Theresa Johnson ,  Reed Johnson ,  Bruce Johnson

IPC分类号： A61F5/44 ,  A61F5/445

摘要： An ostomy pouch replacement device allows ostomates with a surgically created stoma to collect, contain and dispose of bodily fluids during hygienic maintenance. The device is customizable to each ostomate's unique stoma diameter and provides a disposable waste receptacle having a hollow absorbent section and a solid absorbent section for sanitary, discreet and odorless disposal of both urine and excrement. The disposable waste receptacle may include a super absorbent polymer powder that becomes a gel in the presence of liquid. The device preferably consists of a disposable waste receptacle that may be positioned over the stoma and includes an absorbent inner material for capturing waste, a cap or plug for scaling the device after use, and a collar stand for pressing an adhesive wafer to the skin and for holding the assembled device in an upright position.

公开(公告)号：US09416034B2

公开(公告)日：2016-08-16

申请号：US12320526

申请日：2009-01-28

申请人： Bruce Johnson ,  Kevin Doyle ,  Keith Schulte

发明人： Bruce Johnson ,  Kevin Doyle ,  Keith Schulte

IPC分类号： C02F1/66 ,  C02F1/00 ,  C02F1/76 ,  C02F103/42

CPC分类号： C02F1/66 ,  C02F1/008 ,  C02F1/4674 ,  C02F1/76 ,  C02F2103/42 ,  C02F2209/06

摘要： A method and an apparatus for dispensing a pH balancing solution are provided. The apparatus includes a system having a chlorine generator with a power supply coupled to the chlorine generator, the chlorine generator servicing a body of water and chlorinating it. A pH monitoring and balancing unit is provided. The pH monitoring and balancing unit monitors and measures when power is supplied from the power supply to the chlorine generator to produce chlorine and thereby calculates an operational time for the chlorine generator. A pH monitoring and balancing unit controller is also provided, the pH monitoring and balancing unit controller computing an estimated pH level based on the production of the chlorine generator from the operational time measured and then determining if the estimated pH is outside of a desired range, and, if it is outside of the desired range, metering a discrete amount of pH balancing solution based on this estimated pH level to return the pH of the body of water to within the desired range.

摘要翻译： 提供了一种用于分配pH平衡溶液的方法和装置。 该装置包括具有氯发生器的系统，其具有耦合到氯发生器的电源，氯发生器服务于水体并对其进行氯化。 提供pH监测和平衡单元。 pH监测和平衡单元监测和测量从电源向氯气发生器供电以产生氯气，从而计算氯气发生器的运行时间。 还提供pH监测和平衡单元控制器，pH监测和平衡单元控制器根据测量的操作时间计算基于氯发生器的产生的估计的pH水平，然后确定估计的pH是否在期望的范围之外， 并且如果超出所需范围，则基于该估计的pH值计量离散量的pH平衡溶液，以将水体的pH值返回到所需范围内。

公开(公告)号：US09004881B2

公开(公告)日：2015-04-14

申请号：US13452077

申请日：2012-04-20

申请人： Tom M. Simmons ,  John M. Simmons ,  David M. Simmons ,  Bruce Johnson

发明人： Tom M. Simmons ,  John M. Simmons ,  David M. Simmons ,  Bruce Johnson

IPC分类号： F04B45/00 ,  F04B47/08 ,  F04B23/04 ,  F04B7/04 ,  F04B43/12 ,  F04B43/073

CPC分类号： F04B43/1136 ,  F04B43/0736 ,  F04B43/113 ,  F04B45/043 ,  F04B45/0536 ,  F04B45/0736 ,  F04B49/22 ,  F04B53/22 ,  Y10T29/49236

摘要： A fluid pump includes a pump body enclosing a first cavity and a second cavity, a first flexible member disposed within the first cavity, a second flexible member disposed within the second cavity, and a drive shaft extending between and attached to each of the first flexible member and the second flexible member. The drive shaft is configured to slide back and forth within the pump body. The pump also includes a first shift valve and a second shift valve disposed between the first flexible member and the second flexible member, operatively coupled to deliver a drive fluid to drive fluid chambers in alternating sequence. Some fluid pumps disclosed herein include a housing defining a modular-receiving cavity and a modular insert secured within the modular-receiving cavity by an interference fit. Methods of manufacturing and using fluid pumps are also disclosed.

摘要翻译： 流体泵包括：泵体，其包围第一空腔和第二空腔;布置在第一空腔内的第一柔性构件，设置在第二空腔内的第二柔性构件;以及驱动轴，其在第一弹性体 会员和第二个灵活会员。 驱动轴构造成在泵体内前后滑动。 泵还包括设置在第一柔性构件和第二柔性构件之间的第一换档阀和第二换档阀，其可操作地联接以传递驱动流体以交替的顺序驱动流体室。 本文公开的一些流体泵包括限定模块化容纳腔的壳体和通过过盈配合固定在模块化接收腔内的模块化插入件。 还公开了制造和使用流体泵的方法。

公开(公告)号：US20140273052A1

公开(公告)日：2014-09-18

申请号：US13844665

申请日：2013-03-15

申请人： Rakesh Reddy ,  Bruce Johnson ,  Kevin Doyle

发明人： Rakesh Reddy ,  Bruce Johnson ,  Kevin Doyle

IPC分类号： G01N33/18 ,  C12Q1/04 ,  G01N21/77

CPC分类号： G01N33/1893 ,  G01N21/77 ,  G01N33/1813 ,  G01N33/1826

摘要： A sensor system in a water treatment system has a housing, controller, one or more light sources, one or more sensors and one or more targets having an immobilized reagent thereon. Light source emits light energy into the housing that is incident upon the target with the immobilized reagent and the reagent being in contact with water from the system. The immobilized reagent interacts with a reactant in the water such that the interaction changes the state of the reagent. When energy from the light source is incident on the target with the immobilized reagent the energy shows a change detectable by the sensor such that the changed energy is detectable by and collected at the sensor and data on the energy is communicated to the controller. The data is then correlated as a representation of a desired variable to be measured for the water in the water treatment system.

摘要翻译： 水处理系统中的传感器系统具有壳体，控制器，一个或多个光源，一个或多个传感器和一个或多个在其上具有固定化试剂的靶。 光源通过固定的试剂和试剂与来自系统的水接触而将光能发射到入射到靶上的壳体中。 固定化试剂与水中的反应物相互作用，使得相互作用改变了试剂的状态。 当来自光源的能量被固定的试剂入射到目标上时，能量显示出可被传感器检测到的变化，使得改变的能量可由传感器检测并收集在传感器上，数据上的能量被传送到控制器。 然后将数据作为水处理系统中的水测量的期望变量的表示相关联。