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    Recombitope peptides
    1.
    发明授权
    Recombitope peptides 失效
    重组单抗肽

    公开(公告)号：US07211408B2

    公开(公告)日：2007-05-01

    申请号：US10463113

    申请日：2003-06-16

    申请人： Bruce L. Rogers ,  Jay P. Morgenstern ,  Julian F. Bond ,  Richard D. Garman ,  Julia L. Greenstein ,  Mei-Chang Kuo ,  Malcolm Morville

    发明人： Bruce L. Rogers ,  Jay P. Morgenstern ,  Julian F. Bond ,  Richard D. Garman ,  Julia L. Greenstein ,  Mei-Chang Kuo ,  Malcolm Morville

    IPC分类号： G01N33/00 ,  C12N15/09 ,  C07K1/00

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/415 ,  C07K14/47 ,  C07K14/4705 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/40 ,  C12N15/62 ,  G01N33/5091 ,  Y10S530/806 ,  Y10S530/858 ,  Y10S530/868

    摘要： The present invention provides peptides having T cell stimulating activity termed recombitope peptides. Recombitope peptides of the invention preferably comprise at least two T cell epitopes derived from the same or from different protein antigens, and more preferably comprise at least two regions, each region preferably having human T cell stimulating activity and each region comprising at least one T cell epitope derived from a protein antigen. Recombitope peptides of the invention can be derived from protein allergens, autoantigens, or other protein antigens. The invention also provides methods of diagnosing sensitivity to a protein allergen or other protein antigen in an individual, methods to treat such sensitivity and therapeutic compositions comprising one or more recombitope peptides. The invention further provides methods for designing recombitope peptides of the invention where the protein antigen to which the individual is sensitive has unknown or ill-defined T cell epitopes.

    摘要翻译： 本发明提供了称为重组竞争肽的具有T细胞刺激活性的肽。 本发明的重组匹配肽优选包含至少两种衍生自相同或不同蛋白质抗原的T细胞表位，更优选包含至少两个区域，每个区域优选具有人T细胞刺激活性，每个区域包含至少一个T细胞 衍生自蛋白质抗原的表位。 本发明的重组蛋白多肽可以衍生自蛋白质过敏原，自身抗原或其他蛋白质抗原。 本发明还提供诊断个体中蛋白质变应原或其他蛋白质抗原的敏感性的方法，治疗这种敏感性的方法和包含一种或多种重组蛋白多肽的治疗组合物的方法。 本发明还提供了用于设计本发明的重组蛋白肽的方法，其中个体敏感的蛋白质抗原具有未知或不明确的T细胞表位。

    Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response
    6.
    发明授权
    Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response 失效
    用于对人施用能够下调抗原特异性免疫应答的肽的组合物和方法

    公开(公告)号：US06759234B1

    公开(公告)日：2004-07-06

    申请号：US08300510

    申请日：1994-09-02

    申请人： Malcolm L. Gefter ,  Ze′ev Shaked ,  Malcolm Morville

    发明人： Malcolm L. Gefter ,  Ze′ev Shaked ,  Malcolm Morville

    IPC分类号： A61K3816

    CPC分类号： A61K38/16 ,  A61K39/35 ,  A61K2039/545

    摘要： The present invention provides therapeutic compositions and methods for treating disease conditions in humans associated with an antigen specific immune response by the human to an antigen such as a protein antigen (i.e. allergy and autoimmune diseases). Therapeutic compositions of the invention are reproducible preparations which are suitable for human therapy. Compositions of the invention comprise at least one isolated peptide having a defined sequence of amino acid residues and the composition is capable of down regulating an antigen specific immune response to an offending antigen in a population of humans subject to the antigen specific immune response. Compositions and methods of the invention may be used to treat sensitivity to protein allergens in humans and may also be used to treat autoimmune disease such as rheumatoid arthritis, diabetes, myasthenia gravis, Grave's disease, Good Pasture's syndrome, thyroiditis and multiple sclerosis.

    摘要翻译： 本发明提供用于治疗人类与人类对抗原（例如过敏和自身免疫性疾病）的抗原特异性免疫应答相关的疾病状况的治疗组合物和方法。 本发明的治疗组合物是适用于人类治疗的可重复制剂。 本发明的组合物包含具有确定的氨基酸残基序列的至少一种分离的肽，并且该组合物能够下调受抗原特异性免疫应答的人群中的违规抗原的抗原特异性免疫应答。 本发明的组合物和方法可用于治疗人类对蛋白质过敏原的敏感性，并且还可用于治疗自身免疫疾病，例如类风湿性关节炎，糖尿病，重症肌无力，格雷夫斯病，良好牧场综合征，甲状腺炎和多发性硬化。