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公开(公告)号：US5364793A
公开(公告)日：1994-11-15
申请号：US983443
申请日：1992-12-01
IPC分类号： A61K39/395 , C07K16/18 , C12N15/02 , C12P21/08 , C12R1/91 , G01N27/447 , G01N33/50 , G01N33/53 , G01N33/561 , G01N33/577 , G01N33/68 , G01N33/49 , C12Q1/00 , G01N27/26 , G01N33/487
CPC分类号： G01N33/6896 , C07K16/18 , G01N33/561 , G01N33/68 , G01N33/6893 , G01N2800/10 , G01N2800/2842
摘要： Methods of diagnosing peripheral nerve damage, including diagnosing and monitoring chronic back and cervical pain are disclosed. The methods involve subjecting a body fluid sample from a patient suspected of having chronic lumbar or cervical pain and peripheral nerve damage to two-dimensional electrophoresis or an immunoassay and measuring relative amounts of protein or proteins which increase or decrease in concentration as compared to a standard control. A preferred method employs an Apo-E variant as a marker of peripheral nerve damage. Also disclosed are kits for use with the diagnostic methods.
摘要翻译： 公开了诊断周围神经损伤的方法，包括诊断和监测慢性背部和颈部疼痛。 所述方法包括将疑似患有慢性腰椎或颈部疼痛和周围神经损伤的患者的体液样品进行二维电泳或免疫测定，并测量与标准物相比增加或减少浓度的蛋白质或蛋白质的相对量 控制。 优选的方法是使用Apo-E变体作为周围神经损伤的标记物。 还公开了用于诊断方法的试剂盒。
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公开(公告)号：US5583201A
公开(公告)日：1996-12-10
申请号：US242980
申请日：1994-05-16
IPC分类号： A61K39/395 , C07K16/18 , C12N15/02 , C12P21/08 , C12R1/91 , G01N27/447 , G01N33/50 , G01N33/53 , G01N33/561 , G01N33/577 , G01N33/68 , C07K14/435 , A61K38/17 , C07K1/14 , C12Q1/00
CPC分类号： G01N33/6896 , C07K16/18 , G01N33/561 , G01N33/68 , G01N33/6893 , G01N2800/10 , G01N2800/2842
摘要： Methods of diagnosing peripheral nerve damage, including diagnosing and monitoring chronic back and cervical pain are disclosed. The methods involve subjecting a body fluid sample from a patient suspected of having chronic lumbar or cervical pain and peripheral nerve damage to two-dimensional electrophoresis or an immunoassay and measuring relative amounts of protein or proteins which increase or decrease in concentration as compared to a standard control. A preferred method employs an Apo-E variant as a marker of peripheral nerve damage. Also disclosed are kits for use with the diagnostic methods.
摘要翻译： 公开了诊断周围神经损伤的方法，包括诊断和监测慢性背部和颈部疼痛。 所述方法包括将疑似患有慢性腰椎或颈部疼痛和周围神经损伤的患者的体液样品进行二维电泳或免疫测定，并测量与标准物相比增加或减少浓度的蛋白质或蛋白质的相对量 控制。 优选的方法是使用Apo-E变体作为周围神经损伤的标记物。 还公开了用于诊断方法的试剂盒。
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公开(公告)号：US5844097A
公开(公告)日：1998-12-01
申请号：US475345
申请日：1995-06-07
CPC分类号： G01N33/92 , C07K16/18 , G01N33/6896 , G01N2800/10 , G01N2800/2842
摘要： Methods of diagnosing peripheral nerve damage, including diagnosing and monitoring chronic back and cervical pain are disclosed. The methods involve subjecting a body fluid sample from a patient suspected of having chronic lumbar or cervical pain and peripheral nerve damage to two-dimensional electrophoresis or an immunoassay and measuring relative amounts of protein or proteins which increase or decrease in concentration as compared to a standard control. A preferred method employs an Apo-E variant as a marker of peripheral nerve damage. Also disclosed are kits for use with the diagnostic methods.
摘要翻译： 公开了诊断周围神经损伤的方法，包括诊断和监测慢性背部和颈部疼痛。 所述方法包括将疑似患有慢性腰椎或颈部疼痛和周围神经损伤的患者的体液样品进行二维电泳或免疫测定，并测量与标准物相比增加或减少浓度的蛋白质或蛋白质的相对量 控制。 优选的方法是使用Apo-E变体作为周围神经损伤的标记物。 还公开了用于诊断方法的试剂盒。
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