-
公开(公告)号：US5364793A
公开(公告)日：1994-11-15
申请号：US983443
申请日：1992-12-01
IPC分类号： A61K39/395 , C07K16/18 , C12N15/02 , C12P21/08 , C12R1/91 , G01N27/447 , G01N33/50 , G01N33/53 , G01N33/561 , G01N33/577 , G01N33/68 , G01N33/49 , C12Q1/00 , G01N27/26 , G01N33/487
CPC分类号： G01N33/6896 , C07K16/18 , G01N33/561 , G01N33/68 , G01N33/6893 , G01N2800/10 , G01N2800/2842
摘要： Methods of diagnosing peripheral nerve damage, including diagnosing and monitoring chronic back and cervical pain are disclosed. The methods involve subjecting a body fluid sample from a patient suspected of having chronic lumbar or cervical pain and peripheral nerve damage to two-dimensional electrophoresis or an immunoassay and measuring relative amounts of protein or proteins which increase or decrease in concentration as compared to a standard control. A preferred method employs an Apo-E variant as a marker of peripheral nerve damage. Also disclosed are kits for use with the diagnostic methods.
摘要翻译： 公开了诊断周围神经损伤的方法，包括诊断和监测慢性背部和颈部疼痛。 所述方法包括将疑似患有慢性腰椎或颈部疼痛和周围神经损伤的患者的体液样品进行二维电泳或免疫测定，并测量与标准物相比增加或减少浓度的蛋白质或蛋白质的相对量 控制。 优选的方法是使用Apo-E变体作为周围神经损伤的标记物。 还公开了用于诊断方法的试剂盒。
-
公开(公告)号：US5583201A
公开(公告)日：1996-12-10
申请号：US242980
申请日：1994-05-16
IPC分类号： A61K39/395 , C07K16/18 , C12N15/02 , C12P21/08 , C12R1/91 , G01N27/447 , G01N33/50 , G01N33/53 , G01N33/561 , G01N33/577 , G01N33/68 , C07K14/435 , A61K38/17 , C07K1/14 , C12Q1/00
CPC分类号： G01N33/6896 , C07K16/18 , G01N33/561 , G01N33/68 , G01N33/6893 , G01N2800/10 , G01N2800/2842
摘要： Methods of diagnosing peripheral nerve damage, including diagnosing and monitoring chronic back and cervical pain are disclosed. The methods involve subjecting a body fluid sample from a patient suspected of having chronic lumbar or cervical pain and peripheral nerve damage to two-dimensional electrophoresis or an immunoassay and measuring relative amounts of protein or proteins which increase or decrease in concentration as compared to a standard control. A preferred method employs an Apo-E variant as a marker of peripheral nerve damage. Also disclosed are kits for use with the diagnostic methods.
摘要翻译： 公开了诊断周围神经损伤的方法，包括诊断和监测慢性背部和颈部疼痛。 所述方法包括将疑似患有慢性腰椎或颈部疼痛和周围神经损伤的患者的体液样品进行二维电泳或免疫测定，并测量与标准物相比增加或减少浓度的蛋白质或蛋白质的相对量 控制。 优选的方法是使用Apo-E变体作为周围神经损伤的标记物。 还公开了用于诊断方法的试剂盒。
-
公开(公告)号：US5844097A
公开(公告)日：1998-12-01
申请号：US475345
申请日：1995-06-07
CPC分类号： G01N33/92 , C07K16/18 , G01N33/6896 , G01N2800/10 , G01N2800/2842
摘要： Methods of diagnosing peripheral nerve damage, including diagnosing and monitoring chronic back and cervical pain are disclosed. The methods involve subjecting a body fluid sample from a patient suspected of having chronic lumbar or cervical pain and peripheral nerve damage to two-dimensional electrophoresis or an immunoassay and measuring relative amounts of protein or proteins which increase or decrease in concentration as compared to a standard control. A preferred method employs an Apo-E variant as a marker of peripheral nerve damage. Also disclosed are kits for use with the diagnostic methods.
摘要翻译： 公开了诊断周围神经损伤的方法，包括诊断和监测慢性背部和颈部疼痛。 所述方法包括将疑似患有慢性腰椎或颈部疼痛和周围神经损伤的患者的体液样品进行二维电泳或免疫测定，并测量与标准物相比增加或减少浓度的蛋白质或蛋白质的相对量 控制。 优选的方法是使用Apo-E变体作为周围神经损伤的标记物。 还公开了用于诊断方法的试剂盒。
-
公开(公告)号：US06764831B2
公开(公告)日：2004-07-20
申请号：US09444459
申请日：1999-11-22
IPC分类号： C12Q146
CPC分类号： G01N33/523 , A61K38/465 , C12Q1/46 , C12Q2334/30 , C12Q2334/70 , C12Y301/01007 , G01N33/9406 , G01N33/944 , G01N2800/52 , Y10S435/975
摘要： The present invention provides novel methods and diagnostic kits for the objective measurement of the severity of pain or stress being experienced by a patient with a disorder, diagnosis and treatment for patients suffering from painful disorders, and monitoring the effectiveness of different pain-treatment protocols. Pain-measuring methods comprise collecting a sample from a patient and determining the presence of a pain-associated marker in the sample. Methods for alleviating pain comprise administrating a dose of a therapeutically effective amount of a composition to the patient wherein the dose is determined by the presence of a pain-associated marker in a biological sample obtained from the patient. Compositions for alleviating pain comprise substances that are pain-associated markers or agents that interfere with pain-associated markers, and block or modulate the progression of pain perceived by the patient.
摘要翻译： 本发明提供了用于客观测量患有疼痛病症的患者的病症，诊断和治疗的患者经历的疼痛或压力的严重程度以及监测不同疼痛治疗方案的有效性的新型方法和诊断试剂盒。 疼痛测量方法包括从患者收集样品并确定样品中疼痛相关标志物的存在。 减轻疼痛的方法包括向患者施用治疗有效量的组合物的剂量，其中通过在从患者获得的生物样品中存在疼痛相关标志物来确定剂量。 用于缓解疼痛的组合物包括与疼痛相关的标志物或干扰疼痛相关标志物的试剂以及阻断或调节患者感觉到的疼痛进展的物质。
-
-
-
搜索结果
4 条记录 (耗时 0.022 秒)
