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公开(公告)号：US5197467A
公开(公告)日：1993-03-30
申请号：US902242
申请日：1992-06-22
IPC分类号： A61N1/365
CPC分类号： A61N1/36521
摘要： A metabolic demand rate-responsive cardiac stimulation apparatus and method are disclosed which employ multiple physiological rate control parameters, such as respiratory minute volume, patient motion and cardiac stroke volume. The parameters are derived using a single standard pacing lead or transducer. The apparatus and method perform each physiological measurement by periodically applying a measuring current between two points within the apparatus. This measuring current has frequency components in a range of from approximately 10 kilohertz to 1000 megahertz. Application of this measuring current allows the apparatus to detect the voltage which arises from the applied current and, from the detected voltage, to measure the patient's spatial impedance. For a particular measurement, the apparatus controls which physiological parameter is sensed by regulating the frequency content of the measuring current. The apparatus analyzes the physiological parameters to determine the best pacing rate in terms of characteristics such as response time and stability.
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2.发明授权Minute volume rate-responsive pacemaker employing impedance sensing on a unipolar lead 失效在单极引线上采用阻抗感测的分钟体积响应起搏器
公开(公告)号：US5201808A
公开(公告)日：1993-04-13
申请号：US833435
申请日：1992-02-10
IPC分类号： A61N1/365
CPC分类号： A61N1/36521
摘要： A rate-responsive pacemaker employing a rate control parameter of respiratory minute volume, derived over a unipolar lead. The pacemaker performs the minute volume measurement by periodically applying a measuring current between the lead and a reference point on the pacemaker case. This measuring current has frequency components in a range from approximately 10 kilohertz to 1000 megahertz. Application of this measuring current allows the pacemaker to detect the voltage which arises from the applied current and, from the detected voltage, to measure the patient's spatial impedance. Spatial impedance and minute volume vary as a function of the patient's pleural pressure. The pacemaker derives minute volume and rate-responsive pacing rate from the spatial impedance measurement.
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3.发明授权Automatic stimulus artifact reduction for accurate analysis of the heart's stimulated response 失效自动刺激伪影减少，以准确分析心脏的刺激反应
公开(公告)号：US5172690A
公开(公告)日：1992-12-22
申请号：US603988
申请日：1990-10-26
申请人： Tibor A. Nappholz , Fred L. Vance , John W. Camerlo , Bruce M. Steinhaus , Stephen M. Quist , Ken Koestner
发明人： Tibor A. Nappholz , Fred L. Vance , John W. Camerlo , Bruce M. Steinhaus , Stephen M. Quist , Ken Koestner
IPC分类号： A61N1/37
CPC分类号： A61N1/3704
摘要： An apparatus adapted to be implanted in a patient for electrically stimulating the heart and analyzing the heart's stimulated response, and a method of operating the apparatus, are disclosed. The apparatus operates to reduce the stimulation polarization artifact that normally accompanies such stimulation, allowing accurate measurement of stimulated cardiac potentials. The apparatus is useful in such devices as cardiac pacemakers, tachycardia reversion devices, and defibrillators. Optimizing features are provided to allow the apparatus to function properly in noisy environments and with suboptimal leads. In addition, provision is included to make the apparatus capable of performing self-diagnosis for determining when accurate sensing is not possible.
摘要翻译： 公开了一种适于植入患者中的用于电刺激心脏并分析心脏刺激的反应的装置，以及操作该装置的方法。 该装置用于减少通常伴随这种刺激的刺激极化伪影，允许精确测量刺激的心脏电位。 该装置在诸如心脏起搏器，心动过速反转装置和除颤器之类的装置中是有用的。 提供优化功能，以使设备在嘈杂的环境和次优引导下正常工作。 此外，包括提供以使该装置能够进行自诊断以确定何时精确的感测是不可能的。
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4.发明授权
公开(公告)号：US5404877A
公开(公告)日：1995-04-11
申请号：US72570
申请日：1993-06-04
IPC分类号： A61B5/00 , A61B5/0464 , A61B5/0205
CPC分类号： A61B5/0006 , A61B5/0464 , A61B5/7207
摘要： A leadless implantable cardiac arrhythmia alarm is disclosed which continuously assesses a patient's heart function to discriminate between normal and abnormal heart functioning and, upon detecting an abnormal condition, generates a patient-warning signal. The alarm is capable of sensing impedance measurements of heart, respiratory and patient motion and, from these measurements, generating an alarm signal when the measurements indicate the occurrence of a cardiac arrhythmia. Because it requires no external leads or feedthrough connectors, the hermetically-sealed patient alarm is minimally invasive and results in reduced trauma to a patient.
摘要翻译： 公开了一种无引力植入式心律失常报警器，其连续评估患者的心脏功能以区分正常和异常心脏功能，并且在检测到异常状况时产生患者警告信号。 该报警器能够感测心脏，呼吸和患者运动的阻抗测量，并且在这些测量中，当测量显示心律失常的发生时产生报警信号。 因为它不需要外部引线或馈通连接器，所以密封的患者警报器是微创的，并且导致对患者的创伤减少。
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5.发明授权Time domain reflectometer impedance sensor method of use and implantable cardiac stimulator using same 失效时域反射计阻抗传感器的使用方法和可植入式心脏刺激器的使用方法
公开(公告)号：US5361776A
公开(公告)日：1994-11-08
申请号：US104382
申请日：1993-08-06
CPC分类号： A61B5/0538 , A61B5/0535 , A61N1/372 , A61N1/375 , A61N1/3931 , A61N2001/083
摘要： A time domain reflectometry (TDR) impedance sensor is provided for measuring body impedance along a lead or catheter implanted in a patient's cardiovascular system. The TDR sensor applies an electrical stimulus to the lead and measures reflections echoed from impedance variations along and distal to the lead, which are superimposed on the applied stimulus. The measured signals may be analyzed with respect to time-of-flight and distance along the lead to detect a plurality of physiologically meaningful signals.
摘要翻译： 提供了时域反射（TDR）阻抗传感器，用于沿植入患者心血管系统的导联或导管测量身体阻抗。 TDR传感器对引线施加电刺激，并测量从引线的沿着和远端的阻抗变化回波的反射，其叠加在施加的刺激上。 可以相对于飞行时间和沿着引线的距离来分析测量的信号，以检测多个生理上有意义的信号。
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公开(公告)号：US5113869A
公开(公告)日：1992-05-19
申请号：US570379
申请日：1990-08-21
CPC分类号： A61N1/37264 , A61B5/0006 , A61B5/0031 , A61N1/37211 , A61N1/37258 , A61B5/7207 , A61B5/7232 , Y10S128/903
摘要： An implanted programmable ambulatory electrocardiography (AECG) patient monitoring device that senses and analyzes electrocardiographic signals from at least one subcutaneous precordial sensor chronically and frequently to detect electrocardiogram and physiological signal characteristics predictive of malignant cardiac arrhythmias. The device includes telemetric capabilities to communicate a warning signal to an external device when such arrhythmias are predicted.
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7.发明授权Apparatus and method for detecting abnormal cardiac rhythms using evoked potential measurements in an arrhythmia control system 失效在心律失常控制系统中使用诱发电位测量来检测异常心律的装置和方法
公开(公告)号：US5184615A
公开(公告)日：1993-02-09
申请号：US667316
申请日：1991-03-08
CPC分类号： A61N1/3622 , A61N1/3716
摘要： In an implantable antiarryhythmia pacemaker, an automatic cardiac arrhythmia detection and classification monitoring apparatus and method for measuring stimulated intracardiac electrogram potentials, deriving therefrom a paced depolarization integral (PDI), analyzing time-based changes in the PDI, detecting and classifying harmful cardiac rhythms while distinguishing harmful from benign tachycardias, and automatically establishing and initiating an appropriate therapy, if necessary, to revert the arrhythmia condition.
摘要翻译： 在可植入的抗心律失常起搏器中，一种自动心律失常检测和分类监测装置和方法，用于测量刺激的心内电描绘电位，从中得出节奏去极化积分（PDI），分析PDI中的基于时间的变化，检测和分类有害的心律，同时 区分有害的良性心动过速，并在必要时自动建立和启动适当的治疗以恢复心律失常状态。
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8.发明授权Apparatus and method for measuring, formatting and transmitting combined intracardiac impedance data and electrograms 失效用于测量，格式化和发送组合心内阻抗数据和电描记图的装置和方法
公开(公告)号：US5300093A
公开(公告)日：1994-04-05
申请号：US944466
申请日：1992-09-14
申请人： Ken Koestner , Bruce M. Steinhaus , Randy T. Wells
发明人： Ken Koestner , Bruce M. Steinhaus , Randy T. Wells
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/08 , A61B5/6869
摘要： A patient-implantable cardiac stimulation apparatus adapted to measure body impedance, derive at least one physiological parameter from the impedance measurement, sample a time sequence of the physiological parameter and transmit the sequence to an external monitoring device for display and analysis. The apparatus may also sense intracardiac electrograms while it is measuring body impedance and deriving the physiological parameter, in which case it formats and transmits a combined intracardiac electrogram and physiological signal to the monitoring device.
摘要翻译： 一种适于测量身体阻抗的患者植入式心脏刺激装置，从阻抗测量中导出至少一个生理参数，对生理参数的时间序列进行采样，并将该序列发送到外部监测装置进行显示和分析。 该装置还可以在测量身体阻抗并导出生理参数时感测心内电描记图，在这种情况下，其将心内电图和生理信号组合并传输到监测装置。
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公开(公告)号：US5139028A
公开(公告)日：1992-08-18
申请号：US604901
申请日：1990-10-26
申请人： Bruce M. Steinhaus , Fred I. Vance , Anne Curtis , Ken Koestner
发明人： Bruce M. Steinhaus , Fred I. Vance , Anne Curtis , Ken Koestner
IPC分类号： A61B5/00 , A61B5/0452 , A61M5/172 , G06F17/00
CPC分类号： A61M5/1723 , A61B5/0006 , A61B5/04525 , A61B5/413 , A61B5/7217 , A61B5/7207
摘要： An implantable cardiac allograft rejection monitoring apparatus and method for measuring stimulated intracardiac electrogram potentials, performing processing and time based analysis of changes in the potential, and deriving from the time history of the analyzed signals allograft rejection control parameters. The apparatus communicates the allograft rejection control parameters to an external communicating device and may use the parameters to control the output of an implanted drug infusion pump.
摘要翻译： 一种可植入心脏同种异体移植排斥监测装置及方法，用于测量刺激的心内电描记图电位，对电位变化进行处理和基于时间的分析，并从分析的信号同种异体移植排斥控制参数的时间历程中得出。 该装置将同种异体移植排斥控制参数传送到外部通信装置，并且可以使用参数来控制植入药物输注泵的输出。
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10.发明授权Automatic ventricular pacing pulse threshold determination utilizing an external programmer and a surface electrocardiogram 失效使用外部编程器和表面心电图进行自动心室起搏脉冲阈值测定
公开(公告)号：US5391192A
公开(公告)日：1995-02-21
申请号：US205721
申请日：1994-03-04
摘要： A clinical programming system is disclosed for use with an implanted cardiac pacemaker to automatically determine the minimum pacing energy which is necessary to evoke a ventricular depolarization. The system utilizes a series of pacing pulses of progressively decreasing energies to stimulate the ventricle, and detects evoked responses through measurements of the integrals of the R-waves provided by a surface electrocardiogram. Upon loss of capture, the minimum pacing energy is a function of the energy of the last pacing pulse which evoked a ventricular depolarization.
摘要翻译： 公开临床编程系统用于植入的心脏起搏器以自动确定引起心室去极化所必需的最小起搏能量。 该系统利用逐步降低能量的一系列起搏脉冲来刺激心室，并通过测量由表面心电图提供的R波的积分来检测诱发的反应。 在捕获丧失时，最小起搏能量是引起心室去极化的最后起搏脉冲的能量的函数。
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