公开(公告)号：US20060078466A1

公开(公告)日：2006-04-13

申请号：US11251758

申请日：2005-10-18

申请人： Bruno Colin ,  Jacques Dachaud ,  Marie Privat ,  Cecile Paris

发明人： Bruno Colin ,  Jacques Dachaud ,  Marie Privat ,  Cecile Paris

IPC分类号： G01N15/06

CPC分类号： G01N35/1097 ,  B01L3/5025

摘要： The invention concerns a device for implementing a test card inside which sequential reactions and fluid transfer operations are performed under the effect of a control means integrated into the card; said card includes at least two sequential reaction systems arranged in parallel, each reaction system consisting of at least two fluid transfer systems arranged in series. The invention also concerns a test card and the method for implementing the device and the card. The device is characterized in that it contains at least one actuator per reaction line, and all the actuators are at a regular distance from one another, with the actuators preferably being equidistant. The invention is particularly applicable for the micromanipulation of fluids in biological applications.

摘要翻译： 本发明涉及一种用于实现测试卡的设备，其中在集成到卡中的控制装置的作用下执行顺序反应和流体传递操作; 所述卡包括平行布置的至少两个连续的反应系统，每个反应系统由串联布置的至少两个流体传输系统组成。 本发明还涉及测试卡和用于实现设备和卡的方法。 该装置的特征在于，其每个反应管线包含至少一个致动器，并且所有致动器彼此间隔一定距离，致动器优选为等距离的。 本发明特别适用于生物应用中流体的显微操作。

公开(公告)号：US07491497B2

公开(公告)日：2009-02-17

申请号：US11251758

申请日：2005-10-18

申请人： Bruno Colin ,  Jacques Dachaud ,  Marie Privat ,  Cécile Paris

发明人： Bruno Colin ,  Jacques Dachaud ,  Marie Privat ,  Cécile Paris

IPC分类号： C12Q1/68 ,  G01N21/00

CPC分类号： G01N35/1097 ,  B01L3/5025

摘要： A device for implementing a test card inside which sequential reactions and fluid transfer operations are performed under the effect of a control integrated into the card; the card includes at least two sequential reaction systems arranged in parallel, each reaction system having at least two fluid transfer systems arranged in series. A test card and the method for implementing the device and the card are also disclosed. The device contains at least one actuator per reaction line, and all the actuators are at a regular distance from one another, with the actuators preferably being equidistant. The invention is particularly applicable for the micromanipulation of fluids in biological applications.

摘要翻译： 一种用于实现测试卡的装置，其中在集成到卡中的控制的作用下执行顺序反应和流体转移操作; 卡片包括平行布置的至少两个顺序反应系统，每个反应系统具有串联布置的至少两个流体转移系统。 还公开了一种测试卡和用于实现设备和卡的方法。 该装置每个反应管线包含至少一个致动器，并且所有致动器彼此间隔一定距离，致动器优选等距。 本发明特别适用于生物应用中流体的显微操作。

公开(公告)号：US06632287B1

公开(公告)日：2003-10-14

申请号：US09529662

申请日：2000-04-18

申请人： Bruno Colin ,  Marie Privat

发明人： Bruno Colin ,  Marie Privat

IPC分类号： B08B702

CPC分类号： A61L2/04

摘要： The invention provides a method and device for decontaminating a contaminated hollow metal needle having electrical wires attached to the needle which heat cleaning fluid dispensed into the needle.

摘要翻译： 本发明提供了一种用于净化污染的中空金属针的方法和装置，其具有附接到针上的电线，其中分配到针中的热清洁流体。

公开(公告)号：US07097623B2

公开(公告)日：2006-08-29

申请号：US10640646

申请日：2003-08-14

申请人： Bruno Colin ,  Cécile Jaravel ,  Marie Privat

发明人： Bruno Colin ,  Cécile Jaravel ,  Marie Privat

IPC分类号： A61B5/00 ,  B65D81/00 ,  G01N1/10

CPC分类号： G01N35/1016 ,  G01N2035/1025 ,  Y10T436/2575

摘要： A method for drawing a biological sample using a suction-discharge device, such as a manual or automatic pipette, built into an automated device or not. A method for detecting the free surface of a biological sample and/or solid, a sample drawing device such as a pipette and a device for detecting the free surface of a biological sample or a solid are also disclosed. This method includes actuating a means causing a pressure variation or an air flow within the suction-discharge device, positioning the lower free end of the device in such a way so that it becomes flush with a free surface of the biological sample, measuring an overpressure within the suction-discharge device, and sampling a quantity of the sample by suction using the device. The invention finds a preferable application in the field of automatic analyzers.

公开(公告)号：US06641545B1

公开(公告)日：2003-11-04

申请号：US09675648

申请日：2000-09-29

申请人： Bruno Colin ,  Cécile Jaravel ,  Marie Privat

发明人： Bruno Colin ,  Cécile Jaravel ,  Marie Privat

IPC分类号： A61B1000

CPC分类号： G01N35/1016 ,  G01N2035/1025 ,  Y10T436/2575

摘要： A method for drawing a biological sample using a suction-discharge device, such as a manual or automatic pipette, built into an automated device or not. A method for detecting the free surface of a biological sample and/or solid, a sample drawing device such as a pipette and a device for detecting the free surface of a biological sample or a solid are also disclosed. This method includes actuating a means causing a pressure variation or an air flow within the suction-discharge device, positioning the lower free end of the device in such a way so that it becomes flush with a free surface of the biological sample, measuring an overpressure within the suction-discharge device, and sampling a quantity of the sample by suction using the device. The invention finds a preferable application in the field of automatic analyzers.

摘要翻译： 使用内置于自动化装置中的吸引 - 排出装置（例如手动或自动移液管）来绘制生物样品的方法。 还公开了用于检测生物样品和/或固体的自由表面的方法，诸如移液管的样品拉伸装置和用于检测生物样品或固体的游离表面的装置。 该方法包括致动一个在吸入 - 排出装置内产生压力变化或空气流动的装置，以这样的方式定位装置的下部自由端，使其与生物样品的自由表面齐平，测量过压 并且使用该装置通过抽吸对一定量的样品进行采样。 本发明在自动分析仪领域中发现了优选的应用。

公开(公告)号：US07169353B1

公开(公告)日：2007-01-30

申请号：US09936077

申请日：2000-03-09

申请人： Bruno Colin ,  Marie Privat

发明人： Bruno Colin ,  Marie Privat

IPC分类号： G01N33/00

CPC分类号： B01L3/502792 ,  B01L2300/0816 ,  B01L2300/089 ,  B01L2400/0406

摘要： An apparatus (1) which includes at least one planar surface (2) having compartments (3) which are defined by a partition (4), the compartments creating a space which makes it possible to displace at least one liquid sample (5 and/or 15) and, when there are at least two liquid samples (5 and 15), makes it possible to displace them both in an independent way and bring them together so that they can react with one another. The compartments (3) include at least two different types of groove: a deep groove (6), capable of partitioning the sample(s) (5 and/or 15), and a shallow groove capable of receiving the sample (s) (5 and/or 15), the two types of groove (6 and 16) making it possible to direct sample movements (5 and/or 15) by altering the orientation of the apparatus (1). The invention is particularly applicable for the micromanipulation of fluids in biological applications.

摘要翻译： 一种装置（1），其包括至少一个具有由隔板（4）限定的隔室（3）的平坦表面（2），所述隔室产生空间，所述空间使得至少一个液体样品（5和/ 或15），并且当存在至少两个液体样品（5和15）时，可以以独立的方式将它们两者置于一起，使它们彼此反应。 隔室（3）包括至少两种不同类型的槽：能够分隔样品（5和/或15）的深槽（6）和能够接收样品的浅槽（ 5和/或15），两种类型的凹槽（6和16）使得可以通过改变设备（1）的取向来引导样品移动（5和/或15）。 本发明特别适用于生物应用中流体的显微操作。