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公开(公告)号：US20120259249A1
公开(公告)日：2012-10-11
申请号：US13441650
申请日：2012-04-06
CPC分类号： A61N7/022 , A61B8/0808
摘要： Focused ultrasound is a promising technology for neural stimulation that is non-invasive, and capable of passing through the skull. Here we use the isolated retina to characterize the effect of ultrasound on an intact neural circuit and compared these effects to those of visual stimulation of the same retinal ganglion cells. Ultrasound stimuli evoked precise, stable responses that looked qualitatively similar to strong visual responses but with shorter latency. We found that ultrasonic stimulation activates cells presynaptic to ganglion cells, which may include photoreceptors and interneurons. Ultrasonic stimulation is an effective and spatial-temporally precise method to activate the retina. Ultrasonic stimulation may have diagnostic potential to probe remaining retinal function in cases of photoreceptor degeneration, and therapeutic potential for use in a retinal prosthesis. In addition, ultrasound promises to be a useful tool to understand the dynamic activity in the interneuron population of the retina.
摘要翻译： 聚焦超声波是一种有前途的神经刺激技术，非侵入性，能够通过颅骨。 在这里，我们使用孤立的视网膜来表征超声对完整神经回路的影响，并将这些效应与同一视网膜神经节细胞的视觉刺激相比较。 超声刺激诱发精确，稳定的反应，看起来质地与强视觉反应相似，但延迟较短。 我们发现超声波刺激激活细胞突触前神经节细胞，其可能包括光感受器和中间神经元。 超声波刺激是激活视网膜的有效和时空精确的方法。 在光感受器变性的情况下，超声波刺激可能具有探测剩余视网膜功能的诊断潜力，以及用于视网膜假体的治疗潜力。 此外，超声波有助于了解视网膜中间神经元群体的动态活动。
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公开(公告)号：US20130023752A1
公开(公告)日：2013-01-24
申请号：US13554985
申请日：2012-07-20
IPC分类号： A61B6/00
CPC分类号： A61B5/0095 , A61B5/0507
摘要： Surface selective photoacoustic (PA) medical imaging is introduced. Surface selective PA imaging is responsive to surface features and does not image sub-surface features, in contrast to conventional PA imaging. The surface PA signal can be considerably larger than the bulk PA signal, for an air-coupled (or gas-coupled) acoustic transducer. Distinguishing these two signals based on time of arrival at the transducer can further distinguish the two signals. This approach provides numerous advantages.Non-contact imaging simplifies and expedites imaging, and can serve as a replacement for visual inspection by physicians. Applications include skin screening and endoscopy.
摘要翻译： 介绍了表面选择性光声（PA）医学成像。 与传统的PA成像相比，表面选择性PA成像对表面特征有反应，并且不影像亚表面特征。 对于空气耦合（或气体耦合）的声换能器，表面PA信号可以大大地大于体积PA信号。 基于到达换能器的时间区分这两个信号可以进一步区分两个信号。 这种方法提供了许多优点。 非接触式成像简化并加速成像，可作为医生进行视觉检查的替代品。 应用包括皮肤筛查和内窥镜检查。
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3.发明授权Method and apparatus for ultrasound assisted local delivery of drugs and biomarkers 有权用于超声辅助局部递送药物和生物标志物的方法和装置公开(公告)号：US08852104B2
公开(公告)日：2014-10-07
申请号：US12798982
申请日：2010-04-14
CPC分类号： A61B5/0095 , A61B5/0068 , A61B5/0084 , A61B8/4281 , A61B8/4483 , A61M37/0092
摘要： The current invention provides an ultrasound-assisted delivery device, that includes a focused ultrasound transducer having an ultrasound focal point, a real-time imaging device having an imaging focal point, and a therapeutic delivery device, where the transducer and the imaging device are integrated with the delivery device, and the ultrasound focal point coincides with the imaging focal point, where the delivery device and transducer are disposed to provide an unobstructed imaging path for the real-time imaging device. The invention further includes a scanning optical or laser beam having a focal point disposed to sweep across the target, where the delivery device is disposed to deliver an optical contrast material to the target, and the scanning focal point coincides with the ultrasound and imaging focal points, where the target or the optical contrast material react to the scanning beam to generate at least one interface signal.
摘要翻译： 本发明提供了一种超声辅助输送装置，其包括具有超声焦点的聚焦超声换能器，具有成像焦点的实时成像装置和治疗递送装置，其中所述换能器和成像装置被集成 并且超声焦点与成像焦点重合，其中输送装置和换能器被设置成为实时成像装置提供无障碍的成像路径。 本发明还包括扫描光学或激光束，其具有设置成扫过靶的焦点，其中输送装置设置成将光学对比材料输送到靶，并且扫描焦点与超声波和成像焦点重合 ，其中所述目标或所述光学对比材料对所述扫描光束起反应以产生至少一个接口信号。
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公开(公告)号：US08843190B2
公开(公告)日：2014-09-23
申请号：US13554985
申请日：2012-07-20
CPC分类号： A61B5/0095 , A61B5/0507
摘要： Surface selective photoacoustic (PA) medical imaging is introduced. Surface selective PA imaging is responsive to surface features and does not image sub-surface features, in contrast to conventional PA imaging. The surface PA signal can be considerably larger than the bulk PA signal, for an air-coupled (or gas-coupled) acoustic transducer. Distinguishing these two signals based on time of arrival at the transducer can further distinguish the two signals. This approach provides numerous advantages. Non-contact imaging simplifies and expedites imaging, and can serve as a replacement for visual inspection by physicians. Applications include skin screening and endoscopy.
摘要翻译： 介绍了表面选择性光声（PA）医学成像。 与传统的PA成像相比，表面选择性PA成像对表面特征有反应，并且不影像亚表面特征。 对于空气耦合（或气体耦合）的声换能器，表面PA信号可以大大地大于体积PA信号。 基于到达换能器的时间区分这两个信号可以进一步区分两个信号。 这种方法提供了许多优点。 非接触式成像简化并加速成像，可作为医生进行视觉检查的替代品。 应用包括皮肤筛查和内窥镜检查。
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公开(公告)号：US20090292208A1
公开(公告)日：2009-11-26
申请号：US12380889
申请日：2009-03-03
IPC分类号： A61B8/06
CPC分类号： A61B8/06 , A61B5/02007 , G01S15/8927 , G01S15/8979 , G01S15/8984
摘要： Peak blood velocity measurement for automated stenosis detection is provided. Ultrasound measurements of the peak blood velocity are corrected by a calculation of the Doppler angle, which exists from misalignment of the ultrasound transducer axis and the true blood velocity. The direction of the blood velocity and the Doppler angle are found by imaging a set of planar cross-sections of a blood vessel, such as the carotid artery, to obtain velocity maps of the blood flowing in the blood vessel. Peak blood velocity can be correlated with an amount of stenosis therefore accurate peak blood velocity measurements are necessary for medical diagnosis. Automated stenosis detection allows for implementation in many medical settings. A capacitive micromachined ultrasound transducer array is also provided to measure the planar cross-sectional images.
摘要翻译： 提供自动狭窄检测的峰值血液速度测量。 通过计算由超声换能器轴的未对准和真实血液速度存在的多普勒角来校正峰值血液速度的超声测量。 通过对血管如颈动脉的一组平面横截面进行成像来获得血液速度和多普勒角的方向，以获得在血管中流动的血液的速度图。 峰值血流速度可以与狭窄量相关，因此精确的峰值血液速度测量对于医学诊断是必需的。 自动狭窄检测允许在许多医疗设置中实现。 还提供电容微加工超声换能器阵列以测量平面横截面图像。
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6.发明申请Method and apparatus for ultrasound assisted local delivery of drugs and biomarkers 有权用于超声辅助局部递送药物和生物标志物的方法和装置公开(公告)号：US20100268152A1
公开(公告)日：2010-10-21
申请号：US12798982
申请日：2010-04-14
IPC分类号： A61M5/00
CPC分类号： A61B5/0095 , A61B5/0068 , A61B5/0084 , A61B8/4281 , A61B8/4483 , A61M37/0092
摘要： The current invention provides an ultrasound-assisted delivery device, that includes a focused ultrasound transducer having an ultrasound focal point, a real-time imaging device having an imaging focal point, and a therapeutic delivery device, where the transducer and the imaging device are integrated with the delivery device, and the ultrasound focal point coincides with the imaging focal point, where the delivery device and transducer are disposed to provide an unobstructed imaging path for the real-time imaging device. The invention further includes a scanning optical or laser beam having a focal point disposed to sweep across the target, where the delivery device is disposed to deliver an optical contrast material to the target, and the scanning focal point coincides with the ultrasound and imaging focal points, where the target or the optical contrast material react to the scanning beam to generate at least one interface signal.
摘要翻译： 本发明提供了一种超声辅助输送装置，其包括具有超声焦点的聚焦超声换能器，具有成像焦点的实时成像装置和治疗递送装置，其中所述换能器和成像装置被集成 并且超声焦点与成像焦点重合，其中输送装置和换能器被设置成为实时成像装置提供无障碍的成像路径。 本发明还包括扫描光学或激光束，其具有设置成扫过靶的焦点，其中输送装置设置成将光学对比材料输送到靶，并且扫描焦点与超声波和成像焦点重合 ，其中所述目标或所述光学对比材料对所述扫描光束起反应以产生至少一个接口信号。
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7.发明申请Image-guided delivery of therapeutic tools duing minimally invasive surgeries and interventions 审中-公开以图像为导向的治疗工具，提供微创手术和干预措施公开(公告)号：US20080221448A1
公开(公告)日：2008-09-11
申请号：US12072906
申请日：2008-02-27
CPC分类号： B06B1/0292 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4483 , A61B8/4488 , A61B8/483 , A61B10/04 , A61B18/24 , A61B90/36 , A61B2090/3782 , A61B2562/028 , A61N7/022
摘要： Imaged-guided therapy for minimally invasive surgeries and interventions is provided. An image-guided device includes an elongate tubular member, such as a catheter, an annular array of capacitive micromachined ultrasound transducers (cMUTs) for real-time three-dimensional forward-looking acoustic imaging, and a therapeutic tool. The therapeutic tool is positioned inside an inner lumen of the elongate tubular member and can be a device for tissue ablation, such as a high intensity focused ultrasound (HIFU) device or a laser. The HIFU device is operable at high frequencies to have a sufficiently small focus spot, thus a high focal intensity. The imaging annular array is also operable at high frequencies for good acoustic imaging resolution. The high resolution forward-looking imaging array, in combination with the high frequency HIFU transducer, provides a single image-guided therapy device for precise tissue ablation and real-time imaging feedback.
摘要翻译： 提供了用于微创手术和干预措施的成像指导治疗。 图像引导装置包括细长管状构件，例如导管，用于实时三维前瞻性声学成像的电容微加工超声换能器（cMUT）的环形阵列和治疗工具。 治疗工具位于细长管状构件的内腔内，并且可以是用于组织消融的装置，例如高强度聚焦超声（HIFU）装置或激光。 HIFU装置可以在高频下操作以具有足够小的焦点，因此具有高焦距。 成像环形阵列也可在高频下操作以获得良好的声学成像分辨率。 高分辨率前瞻性成像阵列与高频HIFU传感器结合，提供了一个单一的图像引导治疗装置，用于精确的组织消融和实时成像反馈。
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公开(公告)号：US08451693B2
公开(公告)日：2013-05-28
申请号：US12806763
申请日：2010-08-20
CPC分类号： B06B1/0292
摘要： A compression post capacitive micromachined ultrasonic transducer (CMUT) is provided. The compression post CMUT includes a first electrode, a top conductive layer having a pattern of post holes, a moveable mass that includes the first electrode. The compression post CMUT further includes an operating gap disposed between the top surface of the top conductive layer and a bottom surface of the moveable mass, a pattern of compression posts, where a proximal end the compression post is connected perpendicularly to a bottom surface of the moveable mass, where the pattern of compression posts span through the pattern of post holes. The top conductive layer includes the second electrode that is electronically insulated from the first electrode, where the pattern of compression posts compress to provide a restoring force in a direction that is normal to the bottom surface of the moveable mass.
摘要翻译： 提供压缩后电容式微机械超声波换能器（CMUT）。 压缩柱CMUT包括第一电极，具有柱孔图案的顶部导电层，包括第一电极的可移动质量块。 压缩柱CMUT还包括设置在顶部导电层的顶表面和可移动块的底表面之间的操作间隙，压缩柱的图案，其中压缩柱的近端垂直于底部表面连接 可移动质量块，其中压缩柱的图案跨过柱孔的图案。 顶部导电层包括与第一电极电子绝缘的第二电极，其中压缩柱的图案被压缩以在与可移动质量块的底表面垂直的方向上提供恢复力。
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公开(公告)号：US07972271B2
公开(公告)日：2011-07-05
申请号：US11709347
申请日：2007-02-21
IPC分类号： A61B8/14
CPC分类号： A61B8/14 , G01S7/52046 , G01S15/8915 , G01S15/8927 , G01S15/8993
摘要： An invention for coherent array image formation and restoration is taught. The invention is applicable for both 2D and 3D imaging using either 1D or 2D arrays, respectively. A transducer array is subdivided into subarrays, each subarray having a number of adjacent array elements. All elements of each subarray transmit and receive in parallel. The signals received from each subarray are delayed and summed to form scan lines, or beams. The low-beam-rate beams formed from each subarray are upsampled and interpolated prior to forming high-beam-rate images. Depending on the subarray geometry, a subarray-dependent restoration filter is also applied to the subarray beams. The restored beams from each subarray are combined to form the final high-beam-rate image. The invention significantly reduces the front-end hardware complexity compared to conventional methods such as full phased array imaging with comparable image quality.
摘要翻译： 教导了相干阵列图像形成和恢复的发明。 本发明分别适用于使用1D或2D阵列的2D和3D成像。 换能器阵列被细分为子阵列，每个子阵列具有多个相邻的阵列元件。 每个子阵列的所有元素并行传输和接收。 从每个子阵列接收的信号被延迟并相加以形成扫描线或光束。 在形成高光束速率图像之前，从每个子阵列形成的低光束速率光束被上采样和内插。 根据子阵列几何，子阵列依赖的恢复滤波器也被应用于子阵列波束。 来自每个子阵列的恢复的波束被组合以形成最终的高光束速率图像。 与常规方法相比，本发明显着降低了前端硬件复杂性，例如具有可比较图像质量的全相控阵列成像。
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10.发明申请APPARATUS AND METHOD FOR NON-INVASIVE AND MINIMALLY-INVASIVE SENSING OF PARAMETERS RELATING TO BLOOD 审中-公开用于非侵入性和微量入侵感染参数相关血液的装置和方法公开(公告)号：US20100152591A1
公开(公告)日：2010-06-17
申请号：US12618614
申请日：2009-11-13
IPC分类号： A61B5/02
CPC分类号： A61B5/14552 , A61B5/0051 , A61B5/029 , A61B5/14551 , A61B5/1459 , A61B8/00 , A61B8/12
摘要： A system and method for monitoring one or more parameters relating to blood, such as cardiac output, of a patient is provided. The system preferably includes an acoustic energy transducer unit configured and positioned to transmit acoustic energy into a target structure, preferably a blood vessel, within the patient so as to induce a measurable change, preferably a change in blood volume, within the target structure. The transducer unit can be an ultrasonic array, annular array, or groups thereof, or a single element transducer. The unit can also be a vibrator or acoustic loudspeaker. An optical transmitter transmits light into the target structure, and an optical receiver senses light scattered from within the target structure. The blood parameter can then be estimated from the sensed scattered radiation. Relative blood oxygen saturation in the blood vessel can be estimated by transmitting two wavelengths to measure oxy-hemoglobin and deoxy-hemoglobin.
摘要翻译： 提供了一种用于监测与患者血液（例如心输出量）相关的一个或多个参数的系统和方法。 该系统优选地包括声能换能器单元，其被配置和定位成将声能传递到患者体内的目标结构，优选血管，以便在目标结构内引起可测量的变化，优选血容量的变化。 换能器单元可以是超声波阵列，环形阵列或其组，或单个元件换能器。 该单元也可以是振动器或声音扬声器。 光学发射器将光发射到目标结构中，并且光学接收器感测从目标结构内散射的光。 然后可以从感测的散射辐射估计血液参数。 可以通过传输两个波长来估计血管中的相对血氧饱和度来测量氧血红蛋白和脱氧血红蛋白。
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