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公开(公告)号：US09045520B2
公开(公告)日：2015-06-02
申请号：US13491437
申请日：2012-06-07
申请人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanpalan Nagarathnam
发明人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanpalan Nagarathnam
IPC分类号： C07H1/00 , C07H5/02 , C07H15/04 , C07H19/20 , C07H19/167 , C07H19/213
CPC分类号： C07H19/20 , C07H1/00 , C07H5/02 , C07H15/04 , C07H19/167 , C07H19/213 , Y02P20/55
摘要： A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.
摘要翻译： 制备核苷衍生物的氨基磷酸酯前药或环磷酸酯前药的方法，其为化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或其结晶形式。
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公开(公告)号：US08716263B2
公开(公告)日：2014-05-06
申请号：US12645821
申请日：2009-12-23
申请人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanapalan Nagarathnam
发明人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanapalan Nagarathnam
CPC分类号： C07H19/20 , C07H1/00 , C07H5/02 , C07H15/04 , C07H19/167 , C07H19/213 , Y02P20/55
摘要： A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.
摘要翻译： 制备核苷衍生物的氨基磷酸酯前药或环磷酸酯前药的方法，其为化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或其结晶形式。
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公开(公告)号：US20120316327A1
公开(公告)日：2012-12-13
申请号：US13491437
申请日：2012-06-07
申请人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanapalan Nagarathnam
发明人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanapalan Nagarathnam
IPC分类号： C07H1/00 , C07H19/20 , C07H19/213 , C07H15/207
CPC分类号： C07H19/20 , C07H1/00 , C07H5/02 , C07H15/04 , C07H19/167 , C07H19/213 , Y02P20/55
摘要： A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.
摘要翻译： 制备核苷衍生物的氨基磷酸酯前药或环磷酸酯前药的方法，其为化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或其结晶形式。
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公开(公告)号：US08563530B2
公开(公告)日：2013-10-22
申请号：US13076718
申请日：2011-03-31
申请人： Wonsuk Chang , Devan Naduthambi , Dhanapalan Nagarathnam , Ganapati Reddy Pamulapati , Bruce S. Ross , Michael Joseph Sofia , Hai-Ren Zhang
发明人： Wonsuk Chang , Devan Naduthambi , Dhanapalan Nagarathnam , Ganapati Reddy Pamulapati , Bruce S. Ross , Michael Joseph Sofia , Hai-Ren Zhang
CPC分类号： A61K31/7076 , C07H19/207
摘要： Disclosed herein is a compound represented by formula 1 or its hydrate thereof in crystalline or crystal-like form.
摘要翻译： 本文公开了结晶或晶体形式的由式1表示的化合物或其水合物。
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公开(公告)号：US08551973B2
公开(公告)日：2013-10-08
申请号：US12645710
申请日：2009-12-23
摘要： A purified compound having activity against hepatitis C virus is disclosed.
摘要翻译： 公开了具有抗丙型肝炎病毒活性的纯化合物。
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公开(公告)号：US20100286083A1
公开(公告)日：2010-11-11
申请号：US12645710
申请日：2009-12-23
IPC分类号： A61K31/7076 , C07H19/207 , C07H19/10 , A61K31/7072 , A61P31/16 , A61P31/12
摘要： A purified compound having activity against hepatitis C virus is disclosed.
摘要翻译： 公开了具有抗丙型肝炎病毒活性的纯化合物。
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公开(公告)号：US20180230178A1
公开(公告)日：2018-08-16
申请号：US15752144
申请日：2016-08-11
申请人： Michael D. ALTMAN , Brian ANDRESEN , Wonsuk CHANG , Matthew Lloyd CHILDERS , Jared N. CUMMING , Andrew Marc HAIDLE , Timothy J. HENDERSON , James P. JEWELL , Min LU , Alan B. NORTHRUP , Ryan D. OTTE , Tony SIU , Benjamin Wesley TROTTER , Quang T TRUONG , Merck Sharp & Dohme Corp.
发明人： Michael D. Altman , Brian Andresen , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Andrew Marc Haidle , Timothy J. Henderson , James P. Jewell , Min Lu , Alan B. Northrup , Ryan D. Otte , Tony Siu , Benjamin Wesley Trotter , Quang T. Truong
摘要： A class of polycyclic compounds of general formula (II), of general formula (II′), or of general formula (II″), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
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8.发明申请TRIOXANE DIMERS HAVING HIGH ANTICANCER AND LONG-LASTING ANTIMALARIAL ACTIVITIES 审中-公开具有高反应性和长寿命抗生素活性的三氧化二TIES公开(公告)号：US20090291923A1
公开(公告)日：2009-11-26
申请号：US12096015
申请日：2006-11-17
申请人： Gary H. Posner , Ikhyeon Paik , Kristina Borstnik , Wonsuk Chang , Sandra Sinishtaj , William Malo , John Gaetano D'Angelo , Lauren Elaine Woodard , Alvin Solomon Kalinda , Aimee R. Usera , Lindsey Catherine Hess , Andrew Scott Rosenthal , Seongho Oh , Astrid C. Baege
发明人： Gary H. Posner , Ikhyeon Paik , Kristina Borstnik , Wonsuk Chang , Sandra Sinishtaj , William Malo , John Gaetano D'Angelo , Lauren Elaine Woodard , Alvin Solomon Kalinda , Aimee R. Usera , Lindsey Catherine Hess , Andrew Scott Rosenthal , Seongho Oh , Astrid C. Baege
IPC分类号： A61K31/665 , C07D493/18 , C07F9/6561 , A61K31/357 , C07D495/10 , C07D317/12 , C07D317/22 , C07D493/10 , A61P35/00 , C07D263/12
CPC分类号： C07D493/14 , A61K47/55 , C07D493/18 , C07D493/22
摘要： The invention provides novel trioxane dimers having formulae III, IV or V: methods for their preparation, pharmaceutical compositions containing these compounds, and methods for treating cancer and/or malaria using these compounds and compositions.
摘要翻译： 本发明提供具有式III，IV或V的新型三恶烷二聚体：其制备方法，含有这些化合物的药物组合物，以及使用这些化合物和组合物治疗癌症和/或疟疾的方法。
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公开(公告)号：US11685761B2
公开(公告)日：2023-06-27
申请号：US16771814
申请日：2018-12-17
申请人： Merck Sharp & Dohme Corp. , Brian M. Andresen , Frank Bennett , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Jongwon Lim , Min Lu , Benjamin Wesley Trotter , Wen-Lian Wu
发明人： Brian M. Andresen , Frank Bennett , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Jongwon Lim , Min Lu , Benjamin Wesley Trotter , Wen-Lian Wu
IPC分类号： C07H21/00 , A61P37/04 , C07H21/02 , A61K31/7084 , C07H21/04
CPC分类号： C07H21/00 , A61K31/7084 , A61P37/04 , C07H21/02 , C07H21/04 , C07B2200/07
摘要： A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
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公开(公告)号：US20210206796A1
公开(公告)日：2021-07-08
申请号：US16771814
申请日：2018-12-17
申请人： Brian M. ANDRESEN , Frank BENNETT , Wonsuk CHANG , Matthew Lloyd CHILDERS , Jared N. CUMMING , Jongwon LIM , Min LU , Benjamin Wesley TROTTER , Wen-Lian WU , Merck Sharp & Dohme Corp.
发明人： Brian M. Andresen , Frank Bennett , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Jongwon Lim , Min Lu , Benjamin Wesley Trotter , Wen-Lian Wu
摘要： A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
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