公开(公告)号：US06652818B1

公开(公告)日：2003-11-25

申请号：US09378527

申请日：1999-08-20

申请人： C. Randal Mills ,  John F. Wironen ,  Sean Hanstke ,  Russell S. Donda ,  Jamie M. Grooms

发明人： C. Randal Mills ,  John F. Wironen ,  Sean Hanstke ,  Russell S. Donda ,  Jamie M. Grooms

IPC分类号： A61L200

CPC分类号： A61L2/0088 ,  A61L2/025

摘要： This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.

摘要翻译： 本发明包括一种用于在植入有需要的接受者之前安全，有效和有效地汇集用于治疗的组织的新方法。 在一个实施方案中，该方法包括灌注多孔植入物，其实现期望因子的有效相互渗透和植入物孔隙中的不期望因子的去除，植入物的清洁，植入物的有效钝化（病原体，微生物，细胞的灭活 ，病毒等及其抗原性的降低），以及通过这种处理产生的新型植入物。 该过程提出了一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致高度清洁的组织和用于植入的其它植入物。 该过程的目标去污目标包括细菌污染减少约一（1）至十二（12）次，包膜病毒污染减少约一（1）至十五（15）次，最多约五（ 5）无包膜病毒污染减少，内毒素减少约二（2）至十（10）倍，维持植入物或移植物生物学和生物力学性质，由于使用的清洁溶液不存在组织毒性，并减少 植入抗原性。

公开(公告)号：US06613278B1

公开(公告)日：2003-09-02

申请号：US09390174

申请日：1999-09-07

申请人： C. Randal Mills ,  John F. Wironen ,  Sean Hanstke ,  Russell S. Donda ,  Jamie M. Grooms ,  John Bianchi

发明人： C. Randal Mills ,  John F. Wironen ,  Sean Hanstke ,  Russell S. Donda ,  Jamie M. Grooms ,  John Bianchi

IPC分类号： H61L200

CPC分类号： A61F2/28 ,  A61F2/08 ,  A61F2/0811 ,  A61F2/3094 ,  A61F2/442 ,  A61F2/446 ,  A61F2/447 ,  A61F2/4644 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/2839 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/30062 ,  A61F2002/30113 ,  A61F2002/30153 ,  A61F2002/30179 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30235 ,  A61F2002/30261 ,  A61F2002/30266 ,  A61F2002/3028 ,  A61F2002/30329 ,  A61F2002/30354 ,  A61F2002/30383 ,  A61F2002/30387 ,  A61F2002/30448 ,  A61F2002/30492 ,  A61F2002/30563 ,  A61F2002/30599 ,  A61F2002/30677 ,  A61F2002/30785 ,  A61F2002/30795 ,  A61F2002/3085 ,  A61F2002/30904 ,  A61F2002/30957 ,  A61F2002/30975 ,  A61F2002/4649 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2230/0006 ,  A61F2230/0019 ,  A61F2230/0058 ,  A61F2230/0063 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0063 ,  A61F2310/00365 ,  A61F2310/00383 ,  A61F2310/0097 ,  A61F2310/00976 ,  A61L2/0088 ,  A61L2/025

摘要： This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.

摘要翻译： 本发明包括一种用于在植入有需要的接受者之前安全，有效和有效地汇集用于治疗的组织的新方法。 在一个实施方案中，该方法包括灌注多孔植入物，其实现期望因子的有效相互渗透和植入物孔隙中的不期望因子的去除，植入物的清洁，植入物的有效钝化（病原体，微生物，细胞的灭活 ，病毒等及其抗原性的降低），以及通过这种处理产生的新型植入物。 该过程提出了一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致高度清洁的组织和用于植入的其它植入物。 该过程的目标去污目标包括细菌污染减少约一（1）至十二（12）次，包膜病毒污染减少约一（1）至十五（15）次，最多约五（ 5）无包膜病毒污染减少，内毒素减少约二（2）至十（10）倍，维持植入物或移植物生物学和生物力学性质，由于使用的清洁溶液不存在组织毒性，并减少 植入抗原性。

公开(公告)号：US08669043B2

公开(公告)日：2014-03-11

申请号：US13399734

申请日：2012-02-17

申请人： C. Randal Mills ,  John F. Wironen ,  Sean Hanstke

发明人： C. Randal Mills ,  John F. Wironen ,  Sean Hanstke

IPC分类号： A01N1/00 ,  A61L2/18 ,  A61F2/00 ,  A61F2/28

CPC分类号： A01N1/0289 ,  A61L2/0088 ,  A61L2/025

摘要： A method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant, and the implant produced by such treatment. A system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants. Goals include between about a one to twelve log reduction in bacterial contamination, between about a one to fifteen log reduction in enveloped virus contamination, up to about a five log reduction in non-enveloped virus contamination, between about a two to tenfold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.

摘要翻译： 一种用于灌注多孔植入物的方法，其实现期望因子的有效相互渗透和植入物的孔隙中的不期望因子的去除，植入物的清洁，植入物的有效钝化以及通过这种治疗产生的植入物。 一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致高度清洁的组织和其它植入物。 目标包括细菌污染减少约一到十二个对数，包膜病毒污染减少约一至十五个对数，非包膜病毒污染减少约五分之一，内毒素减少约二至十倍 ，植入物或移植物生物学和生物力学性质的维持，由于使用的清洁溶液而导致的组织毒性的缺乏以及植入物抗原性降低。

公开(公告)号：US20120214149A1

公开(公告)日：2012-08-23

申请号：US13399734

申请日：2012-02-17

申请人： C. Randal Mills ,  John F. Wironen ,  Sean Hanstke

发明人： C. Randal Mills ,  John F. Wironen ,  Sean Hanstke

IPC分类号： A01N1/02

CPC分类号： A01N1/0289 ,  A61L2/0088 ,  A61L2/025

摘要： A method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant, and the implant produced by such treatment. A system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants. Goals include between about a one to twelve log reduction in bacterial contamination, between about a one to fifteen log reduction in enveloped virus contamination, up to about a five log reduction in non-enveloped virus contamination, between about a two to tenfold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.

摘要翻译： 一种用于灌注多孔植入物的方法，其实现期望因子的有效相互渗透和植入物的孔隙中的不期望因子的去除，植入物的清洁，植入物的有效钝化以及通过这种治疗产生的植入物。 一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致高度清洁的组织和其它植入物。 目标包括细菌污染减少约一到十二个对数，包膜病毒污染减少约一至十五个对数，非包膜病毒污染减少约五分之一，内毒素减少约二至十倍 ，植入物或移植物生物学和生物力学性质的维持，由于使用的清洁溶液而导致的组织毒性的缺乏以及植入物抗原性降低。

公开(公告)号：US08142991B2

公开(公告)日：2012-03-27

申请号：US12389124

申请日：2009-02-19

申请人： C. Randal Mills ,  John F. Wironen ,  Sean Hanstke

发明人： C. Randal Mills ,  John F. Wironen ,  Sean Hanstke

IPC分类号： A01N1/02 ,  A61L2/18 ,  A61F2/00 ,  A61F2/28

CPC分类号： A01N1/0289 ,  A61L2/0088 ,  A61L2/025

摘要： This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.

摘要翻译： 本发明是一种用于灌注多孔植入物的新方法，其实现期望因子的有效相互渗透和植入物的孔隙中的不期望因子的去除，植入物的清洁，植入物的有效钝化（病原体，微生物，细胞的灭活 ，病毒等及其抗原性的降低），以及通过这种处理产生的新型植入物。 该过程提出了一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致高度清洁的组织和用于植入的其它植入物。 该过程的目标去污目标包括细菌污染减少约一（1）至十二（12）次，包膜病毒污染减少约一（1）至十五（15）次，最多约五（ 5）无包膜病毒污染减少，内毒素减少约二（2）至十（10）倍，维持植入物或移植物生物学和生物力学性质，由于使用的清洁溶液不存在组织毒性，并减少 植入抗原性。

公开(公告)号：US20090186333A1

公开(公告)日：2009-07-23

申请号：US12389124

申请日：2009-02-19

申请人： C. Randal Mills ,  John F. Wironen ,  Sean Hanstke

发明人： C. Randal Mills ,  John F. Wironen ,  Sean Hanstke

IPC分类号： A01N1/02 ,  C12N5/06

CPC分类号： A01N1/0289 ,  A61L2/0088 ,  A61L2/025

摘要： This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.

摘要翻译： 本发明是一种用于灌注多孔植入物的新方法，其实现期望因子的有效相互渗透和植入物的孔隙中的不期望因子的去除，植入物的清洁，植入物的有效钝化（病原体，微生物，细胞的灭活 ，病毒等及其抗原性的降低），以及通过这种处理产生的新型植入物。 该过程提出了一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致高度清洁的组织和用于植入的其它植入物。 该过程的目标去污目标包括细菌污染减少约一（1）至十二（12）次，包膜病毒污染减少约一（1）至十五（15）次，最多约五（ 5）无包膜病毒污染减少，内毒素减少约二（2）至十（10）倍，维持植入物或移植物生物学和生物力学性质，由于使用的清洁溶液不存在组织毒性，并减少 植入抗原性。

公开(公告)号：US07153518B2

公开(公告)日：2006-12-26

申请号：US10228558

申请日：2002-08-27

申请人： John F. Wironen ,  Chris Seid ,  Rebecca Jaw ,  Thien Doan ,  Gregg Ritter ,  Russell S. Donda

发明人： John F. Wironen ,  Chris Seid ,  Rebecca Jaw ,  Thien Doan ,  Gregg Ritter ,  Russell S. Donda

IPC分类号： A61F2/10 ,  A61K9/10 ,  A61K35/36

CPC分类号： A61L27/3834 ,  A61L15/225 ,  A61L15/40 ,  A61L15/44 ,  A61L24/0005 ,  A61L24/0015 ,  A61L24/0094 ,  A61L26/0057 ,  A61L26/0066 ,  A61L26/0095 ,  A61L27/362 ,  A61L27/3683 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/412 ,  A61L2300/414 ,  Y10S424/13 ,  C08L5/00 ,  C08L89/00 ,  C08L89/06

摘要： Disclosed herein are novel injectable, biocompatible compositions, preferably, comprising a combination of particulate, processed tissue and a carrier. Specifically disclosed are compositions comprising acellular, pulverized dermis combined with at least one glycosaminoglycan and/or gelatin. The subject compositions provide for improved retention of the composition at the site of implantation. Also disclosed are medical applications using the disclosed compositions, such as cosmetic enhancement or filling in of voids due to abnormalities, injuries, surgery, or aging. In addition, kits comprising at least one container of a freeze-dried, particulate tissue and at least one container of a glycosaminoglycan, or crude platelet extract and used thereof as a wound treatment/dressing, are disclosed.

公开(公告)号：US08652503B2

公开(公告)日：2014-02-18

申请号：US11152548

申请日：2005-06-14

申请人： John F. Wironen ,  Jamie M. Grooms

发明人： John F. Wironen ,  Jamie M. Grooms

IPC分类号： A61F2/00 ,  A61F13/00 ,  A61F2/28

CPC分类号： A61L27/3608 ,  A61F2/28 ,  A61F2/2875 ,  A61F2/4455 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30622 ,  A61F2210/0004 ,  A61F2310/00179 ,  A61F2310/00293 ,  A61F2310/00329 ,  A61F2310/00383 ,  A61L24/0005 ,  A61L24/0084 ,  A61L24/0094 ,  A61L24/043 ,  A61L24/104 ,  A61L27/222 ,  A61L27/227 ,  A61L27/26 ,  A61L27/36 ,  A61L27/3645 ,  A61L27/46 ,  A61L27/48 ,  A61L2430/02 ,  A61L27/58 ,  A61L27/54 ,  C08L89/00 ,  A61L24/0042 ,  A61L24/0015

摘要： A bone paste useful in the orthopedic arts, for example in the repair of non-union fractures, periodontal ridge augmentation, craniofacial surgery, implant fixation, impaction grafting, or any other procedure in which generation of new bone is deemed necessary, is provided by a composition comprising a substantially bioabsorbable osteogenic compound in a gelatin matrix. In various embodiments, the osteogenic compound is selected from (i) demineralized bone matrix (DBM); (ii) bioactive glass ceramic, BIOGLASS®, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, or like material; (iii) bone morphogenetic protein, TGF-β, PDGF, or mixtures thereof, natural or recombinant; and (iv) mixtures of (i)-(iii).

摘要翻译： 可用于矫形技术的骨膏，例如在修复非联合骨折，牙周脊隆起，颅面手术，植入物固定，撞击移植或认为需要新骨生成的任何其他过程中提供了骨膏 一种在明胶基质中包含基本上生物可吸收的成骨化合物的组合物。 在各种实施方案中，成骨化合物选自（i）去矿化骨基质（DBM）; （ii）生物活性玻璃陶瓷，BIOGLASS®，生物活性陶瓷，磷酸钙陶瓷，羟基磷灰石，羟基磷灰石碳酸盐，舍洛尔羟基磷灰石，煅烧骨，磷酸三钙等; （iii）天然或重组的骨形态发生蛋白，TGF-β，PDGF或其混合物; 和（iv）（i） - （iii）的混合物。

公开(公告)号：US06482584B1

公开(公告)日：2002-11-19

申请号：US09191232

申请日：1998-11-13

申请人： C. Randal Mills ,  John F. Wironen

发明人： C. Randal Mills ,  John F. Wironen

IPC分类号： A01N102

CPC分类号： A01N1/0289 ,  A61L2/0088 ,  A61L2/025

摘要： This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.

摘要翻译： 本发明是一种用于灌注多孔植入物的新方法，其实现期望因子的有效相互渗透和植入物的孔隙中的不期望因子的去除，植入物的清洁，植入物的有效钝化（病原体，微生物，细胞的灭活 ，病毒等及其抗原性的降低），以及通过这种处理产生的新型植入物。 该过程提出了一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致高度清洁的组织和用于植入的其它植入物。 该过程的目标去污目标包括细菌污染减少约一（1）至十二（12）次，包膜病毒污染减少约一（1）至十五（15）次，最多约五（ 5）无包膜病毒污染减少，内毒素减少约二（2）至十（10）倍，维持植入物或移植物生物学和生物力学性质，由于使用的清洁溶液不存在组织毒性，并减少 植入抗原性。

公开(公告)号：US06685626B2

公开(公告)日：2004-02-03

申请号：US09776404

申请日：2001-02-02

申请人： John F. Wironen

发明人： John F. Wironen

IPC分类号： A61F200

CPC分类号： A61K9/0024 ,  A61F2002/4435 ,  A61F2310/00365 ,  A61K38/18 ,  A61L24/0084

摘要： Disclosed and claimed are compositions, devices, methods and kits that are useful in surgical procedures, specifically to induce adhesions for the purposes of stabilizing implants, closing apertures, and otherwise promoting the adhesion of implants and anatomical structures to one another. The invention pertains to a composition containing specific particulate components, wherein the particulates promote an inflammatory reaction that results in the formation of an adhesion.

摘要翻译： 公开和要求保护的是用于外科手术的组合物，装置，方法和试剂盒，特别是为了稳定植入物，闭合孔，以及以其它方式促进植入物和解剖结构彼此粘附的目的诱导粘连。 本发明涉及含有特定颗粒组分的组合物，其中所述颗粒促进导致粘附形成的炎症反应。