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公开(公告)号：US10337043B2
公开(公告)日：2019-07-02
申请号：US15111733
申请日：2015-01-16
申请人： CALYSTA, INC.
摘要： The present disclosure relates to recombinant microorganisms engineered for enhanced production of a desired carbohydrate, as well as related biomass, and compositions which are useful, inter alia, as animal feed ingredients. The present disclosure also provides related methods.
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公开(公告)号：US10011840B2
公开(公告)日：2018-07-03
申请号：US15833890
申请日：2017-12-06
申请人： CALYSTA, INC.
CPC分类号： C12N15/52 , C12N1/20 , C12N9/0006 , C12N9/1205 , C12N9/93 , C12Y101/01008 , C12Y101/01027 , C12Y207/0103 , C12Y602/01001
摘要： The present disclosure relates to genetically engineered methanotrophic bacteria with the capability of growing on a multi-carbon substrate (e.g., glycerol) as a primary or sole carbon source and methods for growing methanotrophic bacteria on the multi-carbon substrate.
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公开(公告)号：US09845474B2
公开(公告)日：2017-12-19
申请号：US14438537
申请日：2013-10-24
申请人： Calysta, Inc.
CPC分类号： C12N15/52 , C12N1/20 , C12N9/0006 , C12N9/1205 , C12N9/93 , C12Y101/01008 , C12Y101/01027 , C12Y207/0103 , C12Y602/01001
摘要： The present disclosure relates to genetically engineered methanotrophic bacteria with the capability of growing on a multi-carbon substrate as a primary or sole carbon source and methods for growing methanotrophic bacteria on a multi-carbon substrate.
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公开(公告)号：US09410168B2
公开(公告)日：2016-08-09
申请号：US14813804
申请日：2015-07-30
申请人： Calysta, Inc.
发明人： Joshua A. Silverman , Sol M. Resnick , Michael Mendez , Renee M. Saville , Sungwon Lee , Luan Nguyen
IPC分类号： C12P7/64 , C12N15/74 , C12P5/00 , C10L1/02 , C10L1/04 , C10G3/00 , C12N9/16 , C12N9/00 , C12N1/16 , C12N1/20 , C12N9/10 , C10G47/00
CPC分类号： C12P7/6409 , C10G3/00 , C10G3/50 , C10G47/00 , C10G2300/1014 , C10L1/02 , C10L1/04 , C10L2200/0469 , C10L2270/02 , C10L2270/04 , C10L2290/26 , C12N1/16 , C12N1/20 , C12N9/1029 , C12N9/16 , C12N9/93 , C12N15/52 , C12N15/74 , C12P5/00 , C12P7/6463 , C12P7/649 , C12R1/01 , C12Y203/01039 , C12Y301/02 , C12Y602/01003 , C12Y604/01002 , Y02E50/13 , Y02E50/343 , Y02P20/52 , Y02P30/20
摘要： The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
摘要翻译： 本公开涉及用于生产生物燃料的生物工程方法，特别是使用C1代谢微生物反应器系统来将C1底物如甲烷或甲醇转化为生物质，随后转化为生物燃料，生物塑料等。
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公开(公告)号：US20170121718A1
公开(公告)日：2017-05-04
申请号：US15319312
申请日：2015-06-18
申请人： Calysta, Inc.
发明人： Renee M. Saville , Joshua Silverman , Jeremy Minshull , Jon Edward Ness , Effendi Leonard , Jana Stumpe , Mark Welch
CPC分类号： C12N15/74 , C12N9/0006 , C12N2830/002 , C12Y101/01244
摘要： The present disclosure provides nucleic acids and vectors for use with methanotrophic bacteria. Related host cells and methods for using such nucleic acids and vectors for expressing polypeptides or other genetic manipulation of methanotrophic bacteria are also provided. In one aspect, the present disclosure is directed to a non-naturally occurring nucleic acid molecule, comprising (1) a promoter that is functional in a methanotrophic bacterium, and (2) a native or altered methanol dehydrogenase (MDH) ribosomal binding sequence, provided that when the promoter is an MDH gene promoter, the nucleic acid comprises an altered MDH ribosomal binding sequence.
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公开(公告)号：US20160289782A1
公开(公告)日：2016-10-06
申请号：US15187509
申请日：2016-06-20
申请人： Calysta, Inc.
发明人： Joshua A. Silverman , Sol M. Resnick , Michael Mendez , Renee M. Saville , Sungwon Lee , Luan Nguyen
CPC分类号： C12P7/6409 , C10G3/00 , C10G3/50 , C10G47/00 , C10G2300/1014 , C10L1/02 , C10L1/04 , C10L2200/0469 , C10L2270/02 , C10L2270/04 , C10L2290/26 , C12N1/16 , C12N1/20 , C12N9/1029 , C12N9/16 , C12N9/93 , C12N15/52 , C12N15/74 , C12P5/00 , C12P7/6463 , C12P7/649 , C12R1/01 , C12Y203/01039 , C12Y301/02 , C12Y602/01003 , C12Y604/01002 , Y02E50/13 , Y02E50/343 , Y02P20/52 , Y02P30/20
摘要： The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
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公开(公告)号：US20160289714A1
公开(公告)日：2016-10-06
申请号：US15187492
申请日：2016-06-20
申请人： Calysta, Inc.
发明人： Joshua A. Silverman , Sol M. Resnick , Michael Mendez , Renee M. Saville , Sungwon Lee , Luan Nguyen
CPC分类号： C12P7/6409 , C10G3/00 , C10G3/50 , C10G47/00 , C10G2300/1014 , C10L1/02 , C10L1/04 , C10L2200/0469 , C10L2270/02 , C10L2270/04 , C10L2290/26 , C12N1/16 , C12N1/20 , C12N9/1029 , C12N9/16 , C12N9/93 , C12N15/52 , C12N15/74 , C12P5/00 , C12P7/6463 , C12P7/649 , C12R1/01 , C12Y203/01039 , C12Y301/02 , C12Y602/01003 , C12Y604/01002 , Y02E50/13 , Y02E50/343 , Y02P20/52 , Y02P30/20
摘要： The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
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8.发明申请MICROORGANISMS FOR THE ENHANCED PRODUCTION OF AMINO ACIDS AND RELATED METHODS 审中-公开用于增强氨基酸生产的微生物及相关方法公开(公告)号：US20150197779A1
公开(公告)日：2015-07-16
申请号：US14599383
申请日：2015-01-16
申请人： CALYSTA, INC.
发明人： Renee M. Saville , Joshua A. Silverman , Eric G. Luning , Brandon D. Doss , Lorraine Joan Giver , Sol M. Resnick , Drew D. Regitsky
IPC分类号： C12P13/08
摘要： The present disclosure relates to recombinant microorganisms engineered for enhance production of a desired amino acid, as well as related biomass, and compositions which are useful, inter alia, as animal feed ingredients. The present invention also provides related methods.
摘要翻译： 本公开涉及用于增强所需氨基酸生产的重组微生物以及相关的生物质，以及特别可用作动物饲料成分的组合物。 本发明还提供了相关方法。
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公开(公告)号：US10190123B2
公开(公告)日：2019-01-29
申请号：US15821510
申请日：2017-11-22
申请人： CALYSTA, INC.
摘要： The present disclosure relates to genetically engineered methanotrophic bacteria with the capability of growing on a multi-carbon substrate (e.g., glucose) as a primary or sole carbon source and methods for growing methanotrophic bacteria on the multi-carbon substrate.
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公开(公告)号：US20180251800A1
公开(公告)日：2018-09-06
申请号：US15882393
申请日：2018-01-29
申请人： Calysta, Inc.
发明人： Joshua A. Silverman , Sol M. Resnick , Michael Mendez , Renee M. Saville , Sungwon Lee , Luan Nguyen
IPC分类号： C12P7/64 , C10G3/00 , C12N15/74 , C12N15/52 , C10G47/00 , C12R1/01 , C12N9/00 , C12N9/16 , C10L1/04 , C10L1/02 , C12N1/20 , C12N9/10 , C12N1/16 , C12P5/00
CPC分类号： C12P7/6409 , C10G3/00 , C10G3/50 , C10G47/00 , C10G2300/1014 , C10L1/02 , C10L1/04 , C10L2200/0469 , C10L2270/02 , C10L2270/04 , C10L2290/26 , C12N1/16 , C12N1/20 , C12N9/1029 , C12N9/16 , C12N9/93 , C12N15/52 , C12N15/74 , C12P5/00 , C12P7/6463 , C12P7/649 , C12R1/01 , C12Y203/01039 , C12Y301/02 , C12Y602/01003 , C12Y604/01002 , Y02E50/13 , Y02E50/343 , Y02P20/52 , Y02P30/20
摘要： The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
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