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    Scalable Manufacturing of Microneedle Arrays Using Automated High-Throughput Manufacturing Systems and High-Capacity Molding
    1.
    发明申请
    Scalable Manufacturing of Microneedle Arrays Using Automated High-Throughput Manufacturing Systems and High-Capacity Molding 有权

    公开(公告)号：US20250082236A1

    公开(公告)日：2025-03-13

    申请号：US18580237

    申请日：2022-07-19

    Applicant: Carnegie Mellon University

    Inventor： O. Burak Ozdoganlar ,  Toygun Cetinkaya ,  Ant Yucesoy ,  Ali Alp Gurer

    IPC: A61B5/15

    Abstract: A manufacturing method for making a plurality of microneedle arrays (MNAs) includes: dispensing a polymer resin into a plurality of wells of at least one mold by an automated dispenser comprising at least one dispensing nozzle; centrifuging the at least one mold to distribute the dispensed polymer resin within the plurality of wells of the at least one mold; curing, solidifying, and/or drying the polymer resin within the plurality of wells of the at least one mold; and removing individual molded MNA parts from the at least one mold with at least one electromechanical mover controlled by at least one computer processor. A mold for making a plurality of the MNAs and a high-throughput manufacturing system for making the MNAs using the mold are also provided.

    HYBRID MICRONEEDLE ARRAYS
    3.
    发明申请
    HYBRID MICRONEEDLE ARRAYS 有权

    公开(公告)号：US20230134699A1

    公开(公告)日：2023-05-04

    申请号：US17917808

    申请日：2021-04-09

    Applicant: Carnegie Mellon University

    Inventor： O. Burak Ozdoganlar ,  Ant Yucesoy

    IPC: A61B5/15

    Abstract: A hybrid microneedle array and a method of fabricating the array is used for delivery of drugs, vaccines, and other therapeutic agents into tissues, including skin, heart, inner ear, and other tissues. The microneedle array can facilitate precise and reproducible intradermal delivery. Each microneedle has a dissolvable tip with a hollow body permitting the delivery of a variety of therapeutic agents into the skin. A fabrication process utilizes a two part mold to separately mold a dissolvable tip and a solid body portion of each microneedle in the array.

    Apparatus and method for implantation of devices into soft tissue
    4.
    发明授权
    Apparatus and method for implantation of devices into soft tissue 有权
    将装置植入软组织的装置和方法

    公开(公告)号：US09408571B2

    公开(公告)日：2016-08-09

    申请号：US13920753

    申请日：2013-06-18

    Applicant: Carnegie Mellon University, Center for Technology Transfer and Enterprise Creation

    Inventor： Peter J. Gilgunn ,  O. Burak Ozdoganlar ,  Takashi Daniel Yoshida Kozai ,  Gary Fedder ,  Xinyan Cui ,  Douglas J. Weber

    IPC: A61B19/00 ,  A61B5/00

    CPC classification number: A61B90/10 ,  A61B5/4851 ,  A61B5/6838 ,  A61B5/6843 ,  A61B34/20 ,  A61B34/30 ,  A61B34/70 ,  A61B2090/064

    Abstract: Apparatus and method for surgeon-assisted rapid surgical implantation of devices into soft tissue. The apparatus comprises several subsystems that enable the referencing of the spatial position and orientation of the device being implanted with respect to the soft tissue into which it is being implanted and then the controlled implantation of the device at a predefined speed with higher positional accuracy and precision and a reduction in soft tissue damage, provided by ultrasonic assisted motion, compared to current state-of-the-art implantation methods and devices. The method includes automated loading of the device being implanted into a clamping mechanism from a cartridge holding a number of implants, referencing of the device position and orientation, referencing of the surface of the tissue into which the device is being implanted, monitoring of the tissue motion, identification of desirable implant location based on the soft tissue profile, allowance of surgeon selection and fine adjustment of the final implant location, high-speed implantation, device release and implant actuator retraction.

    Abstract translation: 用于外科医生辅助的装置和方法将装置快速手术植入软组织。 该装置包括几个子系统，其能够参考相对于其被植入其中的软组织被植入的装置的空间位置和取向，然后以更高的位置精度和精度以预定速度受控地植入装置 并且与当前最先进的植入方法和装置相比，通过超声辅助运动提供的软组织损伤减少。 该方法包括：从被保持多个植入物的药筒自动加载被植入到夹持机构中的装置，参考装置位置和取向，参考装置被植入其中的组织的表面，监测组织 运动，基于软组织轮廓识别期望的植入位置，允许外科医生选择和最终植入位置的精细调整，高速植入，装置释放和植入物致动器缩回。

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