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公开(公告)号：US20170226478A1
公开(公告)日：2017-08-10
申请号：US15458185
申请日：2017-03-14
发明人： Jordan Kerns , Norman Wen , Geraldine Hamilton , Christopher Hinojosa , Jacob Fraser , Catherine Karalis , Janna Nawroth , Dhruv Sareen , Anjoscha Kaus , Berhan Mandefro , Hyoung Shin Park , Ville Kujala
IPC分类号： C12N5/0793 , B01L3/00 , C12N5/077
CPC分类号： C12N5/0619 , C12M23/16 , C12N5/0658 , C12N2502/083 , C12N2506/45 , C12N2531/00 , C12N2533/52
摘要： The invention relates to culturing motor neuron cells together with skeletal muscle cells in a fluidic device under conditions whereby the interaction of these cells mimic the structure and function of the neuromuscular junction (NMJ) providing a NMJ-on-chip. Good viability, formation of myo-fibers and function of skeletal muscle cells on fluidic chips allow for measurements of muscle cell contractions. Embodiments of motor neurons co-cultures with contractile myo-fibers are contemplated for use with modeling diseases affecting NMJ's, e.g. Amyotrophic lateral sclerosis (ALS).
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公开(公告)号：US11767513B2
公开(公告)日：2023-09-26
申请号：US16492906
申请日：2018-03-14
发明人： Dhruv Sareen , Berhan Mandefro , Anjoscha Kaus
CPC分类号： C12N5/0658 , C12N5/0068 , C12N5/0603 , C12N5/0619 , C12N5/0696 , C12N5/0697 , C12N2501/105 , C12N2501/115 , C12N2501/12 , C12N2501/999 , C12N2506/02 , C12N2506/45 , C12N2533/50
摘要： The invention relates to culturing motor neuron cells together with skeletal muscle cells in a fluidic device under conditions whereby the interaction of these cells mimic the structure and function of the neuromuscular junction (NMJ) providing a NMJ-on-chip. Good viability, formation of myo-fibers and function of skeletal muscle cells on fluidic chips allow for measurements of muscle cell contractions. Embodiments of motor neurons co-cultures with contractile myo-fibers are contemplated for use with modeling diseases affecting NMJ's, e.g. Amyotrophic lateral sclerosis (ALS).
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