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公开(公告)号：US11685734B2
公开(公告)日：2023-06-27
申请号：US17111307
申请日：2020-12-03
发明人： Leticia M. Toledo-Sherman , Celia Dominguez , Perla Breccia , Amanda J. Van De Poël , Grant Wishart , Huw D. Vater , William R. K. Esmieu , Cole Clissold , Wesley P. Blackaby
IPC分类号： C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , A61K31/55 , A61K31/5377 , A61K31/505 , A61P21/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P27/02
CPC分类号： C07D413/14 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04
摘要： Provided are certain ATM kinase inhibitors of Formula I:
Also provided herein are compositions of such compounds, and methods of their use.-
公开(公告)号：US10065948B2
公开(公告)日：2018-09-04
申请号：US15315713
申请日：2015-06-01
发明人： Celia Dominguez , Ignacio Muñoz-Sanjuán , Roland W. Bürli , Christopher A. Luckhurst , Daniel R. Allen , Gilles Raphy , Perla Breccia , Alan F. Haughan , Grant Wishart , Samantha J. Hughes , Rebecca E. Jarvis , Huw D. Vater , Stephen D. Penrose , Michael Wall , Andrew J. Stott , Elizabeth A. Saville-Stones
IPC分类号： C07D417/04 , C07D231/54 , C07D401/04 , C07D403/04 , C07D231/56 , C07D239/88 , C07D277/60 , C07D239/70 , C07C259/08
CPC分类号： C07D417/04 , C07C259/08 , C07D231/54 , C07D231/56 , C07D239/70 , C07D239/74 , C07D239/88 , C07D275/04 , C07D277/60 , C07D401/04 , C07D403/04
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use. The condition or disorder mediated by HDAC comprises a neurodegenerative pathology. Accordingly, also provided is a method of treating a neurodegenerative pathology mediated by HDAC in a subject in need of such a treatment, comprising administering to the subject a therapeutically effective amount of at least one compound, or pharmaceutically acceptable salt thereof, described herein.
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公开(公告)号：US10047073B2
公开(公告)日：2018-08-14
申请号：US15148884
申请日：2016-05-06
发明人： Michel C. Maillard , Perla Breccia , Celia Dominguez , Alan F. Haughan , Rebecca E. Jarvis , Christopher A. Luckhurst , Elizabeth A. Saville-Stones , Andrew J. Stott , Amanda Van de Poël , Michael Wall , Grant Wishart
IPC分类号： C07D413/12 , C07D491/107
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US20170305900A1
公开(公告)日：2017-10-26
申请号：US15482327
申请日：2017-04-07
发明人： Celia Dominguez , Ignacio Muñoz-Sanjuán , Michel Maillard , Christopher A. Luckhurst , Rebecca E. Jarvis , Roland W. Bürli , Daniel R. Allen , Alan F. Haughan , Perla Breccia , Huw D. Vater , Andrew J. Stott , Stephen D. Penrose , Michael Wall , Elizabeth A. Saville-Stones , Grant Wishart , Samantha J. Hughes
IPC分类号： C07D471/04 , C07D277/64 , C07C259/08 , C07D277/62 , C07D275/04 , C07D261/20 , C07D241/42 , C07D241/12 , C07D239/26 , C07D231/56 , C07D231/12 , C07D213/64 , C07D213/61 , C07D213/56 , C07D333/60 , C07C2601/02 , C07C2601/10
CPC分类号： C07D471/04 , C07C259/08 , C07C2601/02 , C07C2601/10 , C07D213/56 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/56 , C07D239/26 , C07D241/12 , C07D241/42 , C07D261/20 , C07D275/04 , C07D277/62 , C07D277/64 , C07D333/60
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US20190062321A1
公开(公告)日：2019-02-28
申请号：US16049482
申请日：2018-07-30
发明人： Celia Dominguez , Ignacio Muñoz-Sanjuán , Roland W. Bürli , Christopher A. Luckhurst , Daniel R. Allen , Gilles Raphy , Perla Breccia , Alan F. Haughan , Grant Wishart , Samantha J. Hughes , Rebecca E. Jarvis , Huw D. Vater , Stephen D. Penrose , Michael Wall , Andrew J. Stott , Elizabeth A. Saville-Stones
IPC分类号： C07D417/04 , C07D275/04 , C07D231/56 , C07C259/08 , C07D277/60 , C07D231/54 , C07D239/74 , C07D239/70 , C07D403/04 , C07D401/04 , C07D239/88
CPC分类号： C07D417/04 , C07C259/08 , C07D231/54 , C07D231/56 , C07D239/70 , C07D239/74 , C07D239/88 , C07D275/04 , C07D277/60 , C07D401/04 , C07D403/04
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use.
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公开(公告)号：US09783488B2
公开(公告)日：2017-10-10
申请号：US14776280
申请日：2014-03-10
发明人： Celia Dominguez , Ignacio Muñoz-Sanjuán , Michel Maillard , Gilles Raphy , Alan F. Haughan , Christopher A. Luckhurst , Rebecca E. Jarvis , Roland W. Bürli , Perla Breccia , Grant Wishart , Samantha J. Hughes , Daniel R. Allen , Stephen D. Penrose
IPC分类号： A61K31/133 , C07C233/60 , C07D263/56 , C07D215/14 , C07D231/12 , C07D231/56 , C07D333/54 , C07D235/08 , C07D239/26 , C07D471/04 , C07D265/36 , C07D277/64 , C07D295/073 , C07D213/54 , C07D213/56 , C07D307/79 , C07C259/08 , C07D209/46 , C07D213/58 , C07D215/06 , C07D235/06 , C07D263/57 , C07D265/30 , C07D277/66 , C07D307/81 , C07D311/96 , C07D401/12 , C07D413/06
CPC分类号： C07C233/60 , C07C259/08 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D209/46 , C07D213/54 , C07D213/56 , C07D213/58 , C07D215/06 , C07D215/14 , C07D231/12 , C07D231/56 , C07D235/06 , C07D235/08 , C07D239/26 , C07D263/56 , C07D263/57 , C07D265/30 , C07D265/36 , C07D277/64 , C07D277/66 , C07D295/073 , C07D307/79 , C07D307/81 , C07D311/96 , C07D333/54 , C07D401/12 , C07D413/06 , C07D471/04
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US20160333001A1
公开(公告)日：2016-11-17
申请号：US15148884
申请日：2016-05-06
发明人： Celia Dominguez , Michel C. Maillard , Perla Breccia , Alan F. Haughan , Rebecca E. Jarvis , Christopher A. Luckhurst , Elizabeth A. Saville-Stones , Andrew J. Stott , Amanda Van de Poël , Michael Wall , Grant Wishart
IPC分类号： C07D413/12 , C07D491/107
CPC分类号： C07D413/12 , C07D491/107
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US20190185463A1
公开(公告)日：2019-06-20
申请号：US16046268
申请日：2018-07-26
发明人： Michel C. Maillard , Perla Breccia , Celia Dominguez , Alan F. Haughan , Rebecca E. Jarvis , Christopher A. Luckhurst , Elizabeth A. Saville-Stones , Andrew J. Stott , Amanda Van de Poël , Michael Wall , Grant Wishart
IPC分类号： C07D413/12 , C07D491/107
CPC分类号： C07D413/12 , C07D491/107
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US10053434B2
公开(公告)日：2018-08-21
申请号：US15148907
申请日：2016-05-06
发明人： Michel C. Maillard , Perla Breccia , Celia Dominguez , Alan F. Haughan , Amanda Van de Poël , Andrew J. Stott , Christopher A. Luckhurst , Elizabeth A. Saville-Stones , Grant Wishart , Michael Wall , Rebecca E. Jarvis
IPC分类号： C07D413/12 , C07D271/06 , C07D471/04
CPC分类号： C07D271/06 , C07D413/12 , C07D471/04
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US20170101402A1
公开(公告)日：2017-04-13
申请号：US15315713
申请日：2015-06-01
发明人： Celia Dominguez , Ignacio Muñoz-Sanjuán , Christopher A. Luckhurst , Daniel R. Allen , Gilles Raphy , Roland W. Bürli , Perla Breccia , Alan F. Haughan , Grant Wishart , Samantha J. Hughes , Rebeca E. Jarvis , Huw D. Vater , Stephen D. Penrose , Michael Wall , Andrew J. Stott , Elizabeth A. Saville-Stones
IPC分类号： C07D417/04 , C07D401/04 , C07D403/04 , C07C259/08 , C07D239/88 , C07D277/60 , C07D239/70 , C07D231/54 , C07D231/56
CPC分类号： C07D417/04 , C07C259/08 , C07D231/54 , C07D231/56 , C07D239/70 , C07D239/74 , C07D239/88 , C07D275/04 , C07D277/60 , C07D401/04 , C07D403/04
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use. The condition or disorder mediated by HDAC comprises a neurodegenerative pathology. Accordingly, also provided is a method of treating a neurodegenerative pathology mediated by HDAC in a subject in need of such a treatment, comprising administering to the subject a therapeutically effective amount of at least one compound, or pharmaceutically acceptable salt thereof, described herein.
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