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公开(公告)号：US10457675B2
公开(公告)日：2019-10-29
申请号：US16049482
申请日：2018-07-30
发明人： Celia Dominguez , Ignacio Muñoz-Sanjuán , Roland W. Bürli , Christopher A. Luckhurst , Daniel R. Allen , Gilles Raphy , Perla Breccia , Alan F. Haughan , Grant Wishart , Samantha J. Hughes , Rebecca E. Jarvis , Huw D. Vater , Stephen D. Penrose , Michael Wall , Andrew J. Stott , Elizabeth A. Saville-Stones
IPC分类号： C07D417/04 , C07D231/54 , C07D401/04 , C07D403/04 , C07D239/70 , C07D239/74 , C07D239/88 , C07D277/60 , C07C259/08 , C07D231/56 , C07D275/04
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use.
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公开(公告)号：US20160031876A1
公开(公告)日：2016-02-04
申请号：US14776320
申请日：2014-03-10
发明人： Celia Dominguez , Ignacio Muñoz-Sanjuán , Michel Maillard , Christopher A. Luckhurst , Rebecca E. Jarvis , Roland W. Bürli , Daniel R. Allen , Alan F. Haughan , Perla Breccia , Huw D. Vater , Andrew J. Stott , Stephen D. Penrose , Michael Wall , Elizabeth A. Saville-Stones , Grant Wishart , Samantha J. Hughes
IPC分类号： C07D471/04 , C07D213/56 , C07D241/12 , C07D239/26 , C07D213/61 , C07D333/60 , C07D231/12 , C07D261/20 , C07D213/64 , C07D275/04 , C07D277/64 , C07C259/08 , C07D241/42
CPC分类号： C07D471/04 , C07C259/08 , C07C2601/02 , C07C2601/10 , C07D213/56 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/56 , C07D239/26 , C07D241/12 , C07D241/42 , C07D261/20 , C07D275/04 , C07D277/62 , C07D277/64 , C07D333/60
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US20190062321A1
公开(公告)日：2019-02-28
申请号：US16049482
申请日：2018-07-30
发明人： Celia Dominguez , Ignacio Muñoz-Sanjuán , Roland W. Bürli , Christopher A. Luckhurst , Daniel R. Allen , Gilles Raphy , Perla Breccia , Alan F. Haughan , Grant Wishart , Samantha J. Hughes , Rebecca E. Jarvis , Huw D. Vater , Stephen D. Penrose , Michael Wall , Andrew J. Stott , Elizabeth A. Saville-Stones
IPC分类号： C07D417/04 , C07D275/04 , C07D231/56 , C07C259/08 , C07D277/60 , C07D231/54 , C07D239/74 , C07D239/70 , C07D403/04 , C07D401/04 , C07D239/88
CPC分类号： C07D417/04 , C07C259/08 , C07D231/54 , C07D231/56 , C07D239/70 , C07D239/74 , C07D239/88 , C07D275/04 , C07D277/60 , C07D401/04 , C07D403/04
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use.
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公开(公告)号：US09855267B2
公开(公告)日：2018-01-02
申请号：US15335279
申请日：2016-10-26
IPC分类号： A61K31/505 , A61K31/165 , A61K31/357 , A61K31/4418 , A61K31/421 , A61K31/426 , C07D213/74 , C07D311/58 , C07D319/18 , C07D401/04 , C07D237/08 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D417/04 , C07D263/32 , C07D277/30 , C07D213/56 , C07D213/61 , C07D263/56 , C07D215/18 , C07D277/64 , C07D295/155 , C07C259/08
CPC分类号： A61K31/505 , A61K31/165 , A61K31/357 , A61K31/421 , A61K31/426 , A61K31/4418 , C07B2200/07 , C07C259/08 , C07C2601/02 , C07D213/56 , C07D213/61 , C07D213/74 , C07D215/18 , C07D237/08 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D263/32 , C07D263/56 , C07D277/30 , C07D277/64 , C07D295/155 , C07D311/58 , C07D319/18 , C07D401/04 , C07D417/04
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US09783488B2
公开(公告)日：2017-10-10
申请号：US14776280
申请日：2014-03-10
发明人： Celia Dominguez , Ignacio Muñoz-Sanjuán , Michel Maillard , Gilles Raphy , Alan F. Haughan , Christopher A. Luckhurst , Rebecca E. Jarvis , Roland W. Bürli , Perla Breccia , Grant Wishart , Samantha J. Hughes , Daniel R. Allen , Stephen D. Penrose
IPC分类号： A61K31/133 , C07C233/60 , C07D263/56 , C07D215/14 , C07D231/12 , C07D231/56 , C07D333/54 , C07D235/08 , C07D239/26 , C07D471/04 , C07D265/36 , C07D277/64 , C07D295/073 , C07D213/54 , C07D213/56 , C07D307/79 , C07C259/08 , C07D209/46 , C07D213/58 , C07D215/06 , C07D235/06 , C07D263/57 , C07D265/30 , C07D277/66 , C07D307/81 , C07D311/96 , C07D401/12 , C07D413/06
CPC分类号： C07C233/60 , C07C259/08 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D209/46 , C07D213/54 , C07D213/56 , C07D213/58 , C07D215/06 , C07D215/14 , C07D231/12 , C07D231/56 , C07D235/06 , C07D235/08 , C07D239/26 , C07D263/56 , C07D263/57 , C07D265/30 , C07D265/36 , C07D277/64 , C07D277/66 , C07D295/073 , C07D307/79 , C07D307/81 , C07D311/96 , C07D333/54 , C07D401/12 , C07D413/06 , C07D471/04
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US10065948B2
公开(公告)日：2018-09-04
申请号：US15315713
申请日：2015-06-01
发明人： Celia Dominguez , Ignacio Muñoz-Sanjuán , Roland W. Bürli , Christopher A. Luckhurst , Daniel R. Allen , Gilles Raphy , Perla Breccia , Alan F. Haughan , Grant Wishart , Samantha J. Hughes , Rebecca E. Jarvis , Huw D. Vater , Stephen D. Penrose , Michael Wall , Andrew J. Stott , Elizabeth A. Saville-Stones
IPC分类号： C07D417/04 , C07D231/54 , C07D401/04 , C07D403/04 , C07D231/56 , C07D239/88 , C07D277/60 , C07D239/70 , C07C259/08
CPC分类号： C07D417/04 , C07C259/08 , C07D231/54 , C07D231/56 , C07D239/70 , C07D239/74 , C07D239/88 , C07D275/04 , C07D277/60 , C07D401/04 , C07D403/04
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use. The condition or disorder mediated by HDAC comprises a neurodegenerative pathology. Accordingly, also provided is a method of treating a neurodegenerative pathology mediated by HDAC in a subject in need of such a treatment, comprising administering to the subject a therapeutically effective amount of at least one compound, or pharmaceutically acceptable salt thereof, described herein.
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公开(公告)号：US20170305900A1
公开(公告)日：2017-10-26
申请号：US15482327
申请日：2017-04-07
发明人： Celia Dominguez , Ignacio Muñoz-Sanjuán , Michel Maillard , Christopher A. Luckhurst , Rebecca E. Jarvis , Roland W. Bürli , Daniel R. Allen , Alan F. Haughan , Perla Breccia , Huw D. Vater , Andrew J. Stott , Stephen D. Penrose , Michael Wall , Elizabeth A. Saville-Stones , Grant Wishart , Samantha J. Hughes
IPC分类号： C07D471/04 , C07D277/64 , C07C259/08 , C07D277/62 , C07D275/04 , C07D261/20 , C07D241/42 , C07D241/12 , C07D239/26 , C07D231/56 , C07D231/12 , C07D213/64 , C07D213/61 , C07D213/56 , C07D333/60 , C07C2601/02 , C07C2601/10
CPC分类号： C07D471/04 , C07C259/08 , C07C2601/02 , C07C2601/10 , C07D213/56 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/56 , C07D239/26 , C07D241/12 , C07D241/42 , C07D261/20 , C07D275/04 , C07D277/62 , C07D277/64 , C07D333/60
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US20170224684A1
公开(公告)日：2017-08-10
申请号：US15411535
申请日：2017-01-20
发明人： Celia Dominguez , Vahri Beaumont , Ignacio Muñoz-Sanjuán , Roland W. Bürli , Alan F. Haughan , Christopher A. Luckhurst , Michael Wall , Gilles Raphy , Beth Thomas
IPC分类号： A61K31/505
CPC分类号： A61K31/505 , C07D239/26
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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9.发明授权公开(公告)号：US09562021B2
公开(公告)日：2017-02-07
申请号：US14776039
申请日：2014-03-10
发明人： Celia Dominguez , Vahri Beaumont , Ignacio Muñoz-Sanjuán , Roland W. Bürli , Alan F. Haughan , Christopher A. Luckhurst , Michael Wall , Gilles Raphy , Beth Thomas
IPC分类号： C07D239/26 , A61K31/505
CPC分类号： A61K31/505 , C07D239/26
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
摘要翻译： 提供式I的组蛋白脱乙酰酶（HDAC）抑制剂，其组合物及其使用方法。
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公开(公告)号：US20160024019A1
公开(公告)日：2016-01-28
申请号：US14776039
申请日：2014-03-10
发明人： Celia Dominguez , Ignacio Muñoz-Sanjuán , Vahri Beaumont , Maria Beconi , Roland W. Bürli , Alan F. Haughan , Christopher A. Luckhurst , Michael Wall , Gilles Raphy , Beth Thomas
IPC分类号： C07D239/26
CPC分类号： A61K31/505 , C07D239/26
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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