公开(公告)号：US20040084358A1

公开(公告)日：2004-05-06

申请号：US10642606

申请日：2003-08-19

申请人： CHF Solutions, Inc.

发明人： John J. O'Mahony ,  Andrew Hal Pert ,  Mark Gelfand

IPC分类号： B01D063/00

CPC分类号： A61M1/16 ,  A61M1/1692 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3607 ,  A61M1/3609 ,  A61M1/3639 ,  A61M1/3641 ,  A61M2205/14 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3331 ,  A61M2205/3344 ,  A61M2205/3375 ,  A61M2205/50 ,  A61M2205/502 ,  G06F19/00 ,  Y10S706/924

摘要： A graphical user interface for a medical instruments for a Renal Replacement Therapy is disclosed that includes a pictogram representation of the fluid path of an extracorporeal blood circuit that represents fluid lines, pumps and sensors. To assist the user in responding to alarms and rectifying faults in the system the source of a potential trouble is animated. The location of a trouble spot is easily identified by flashing of the corresponding element of the pictogram, change of color or thickness of a corresponding line.

公开(公告)号：US20040176813A1

公开(公告)日：2004-09-09

申请号：US10801059

申请日：2004-03-16

申请人： CHF Solutions Inc.

发明人： Mark Gelfand ,  John O'Mahony ,  Howard R. Levin

IPC分类号： A61N001/08

CPC分类号： A61M1/34 ,  A61M1/341 ,  A61M1/36 ,  A61M2205/3303 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3375 ,  A61M2205/50 ,  A61M2230/205 ,  A61M2230/005

摘要： A method and system for the extracorporeal treatment of blood to remove fluid from the fluid overloaded patient is disclosed that non-invasively measures an oxygen level in the venous blood. The oxygen blood level is used to detect when hypotension is about to occur in a patient. The oxygen level measurements are used as feedback signals. These feedback signals are applied to automatically control the rate of fluid extraction to achieve the desired clinical outcome and avoid precipitating a hypotensive crisis in the patient.

公开(公告)号：US20040030277A1

公开(公告)日：2004-02-12

申请号：US10601574

申请日：2003-06-24

申请人： CHF Solutions, Inc.

发明人： John J. O'Mahony ,  Mark Gelfand ,  Edward G. Rychlick

IPC分类号： A61M037/00 ,  C02F001/00

CPC分类号： A61M1/34 ,  A61M1/1692 ,  A61M1/341 ,  A61M1/3639 ,  A61M1/3656 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2205/502 ,  B01D61/22

摘要： A method and apparatus for controlling blood withdrawal and infusion flow rate with the use of a pressure controller. The pressure controller uses pressure targets based upon occlusion limits that are calculated as a function of flow. The controller has the ability to switch from controlling withdrawal pressure to controlling infusion pressure based upon the detection of an occlusion. The controller distinguishes between partial and total occlusions of the withdrawal vein providing blood access. Depending on the nature of occlusion, the controller limits or temporarily reverses blood flow and, thus, prevents withdrawal vessel collapse or reverses blood flow to quickly infuse blood into the vessel without participation from operator.

摘要翻译： 一种使用压力控制器控制取血和输注流速的方法和装置。 压力控制器使用基于作为流量的函数计算的阻塞极限的压力目标。 控制器能够根据遮挡的检测从控制提取压力转换到控制输液压力。 控制器区分提供血液通道的撤离静脉的部分和全部闭塞。 根据闭塞的性质，控制器限制或暂时逆转血液流动，从而防止撤离血管塌陷或逆转血液，以便在没有操作者参与的情况下将血液快速注入血管。

公开(公告)号：US20040054315A1

公开(公告)日：2004-03-18

申请号：US10642638

申请日：2003-08-19

申请人： CHF Solutions, Inc.

发明人： Howard R. Levin ,  Mark Gelfand ,  John O'Mahony ,  Hans-Dietrich Polaschegg

IPC分类号： A61M037/00 ,  C02F001/44 ,  B01D011/00

CPC分类号： A61M1/341 ,  A61M1/1692 ,  A61M1/34 ,  A61M1/361 ,  A61M1/3612 ,  A61M2205/3393 ,  A61M2205/50 ,  A61M2205/7563

摘要： A method and apparatus for ultrafiltration of blood operating by removing blood from a peripheral blood vessel at a rate of less than two percent of total cardiac output of a patient, extracting fluid at a rate of 0.1 liter to 1.0 liters per hour while retaining cells and proteins in the blood, and returning the concentrated blood to a secondary blood vessel is disclosed. Blood is removed and returned using small gage needles. As a pump circulates blood from the patient, a filter removes ultrafiltrate from the blood using duty cycle or pump control, and a transparent container collects the removed fluid.

摘要翻译： 一种通过以小于患者总心输出量的百分之二的速率从外周血管中除血的血液超滤操作的方法和装置，以每小时0.1升至1.0升的速率提取液体，同时保留细胞和 公开了血液中的蛋白质，并将浓缩血液返回到二次血管。 使用小规格针头取出血液并返回。 当泵从患者循环血液时，过滤器使用占空比或泵控制从血液中除去超滤液，并且透明容器收集去除的流体。

公开(公告)号：US20040044302A1

公开(公告)日：2004-03-04

申请号：US10653100

申请日：2003-09-03

申请人： CHF Solutions, Inc.

发明人： Steven J. Bernard ,  John J. O'Mahony ,  Andrew J. Halpert ,  Mark Gelfand ,  Howard R. Levin

IPC分类号： A61M037/00 ,  B01D024/00 ,  B01D033/00

CPC分类号： A61M1/34 ,  A61M1/341 ,  A61M1/342 ,  A61M1/3431 ,  A61M1/3441 ,  A61M1/3451 ,  A61M1/36 ,  A61M1/3613 ,  A61M1/3615 ,  A61M1/3621 ,  A61M2205/15 ,  A61M2205/3331 ,  B01D61/145 ,  B01D61/22

摘要： An extracorpeal blood circuit for removal of contrast from human blood using a filter and withdrawal filter pump and a by-pass pump. The withdrawal filter blood pump operates when a contrast bolus has been detected. Otherwise the bypass blood pump maintains physiological blood flow from the coronary sinus preventing the need for deflation and re-inflation of the balloon catheter. When contrast is detected blood the bypass blood pump is stopped to prevent contrast from leaking back into the patients circulatory system via the bypass pump and CS blood flow is maintained at its physiological blood flow resulting in the heart being oblivious to the transition by the prefilter blood pump.

公开(公告)号：US20040044301A1

公开(公告)日：2004-03-04

申请号：US10647266

申请日：2003-08-26

申请人： CHF Solutions, Inc.

发明人： Howard R. Levin ,  Mark Gelfand ,  Steve J. Bernard

IPC分类号： A61M037/00 ,  C02F001/44 ,  B01D011/00

CPC分类号： A61M1/34 ,  A61M1/36 ,  A61M25/0014 ,  A61M2205/15 ,  A61M2205/502

摘要： Method and apparatus for the extracorporeal treatment of blood by utilizing a peripherally inserted catheter assembly for the continuous removal of blood for renal replacement treatment, in particularly, treatment of congestive heart failure and fluid overload by ultrafiltration. A catheter is inserted in a peripheral vein and maneuvered upward through the vascular system to access the reservoir of blood in the large or great veins for continuous blood withdrawal and treatment. Air-tight connectors are incorporated in the catheter assembly to overcome the untoward effects of negative pressure in blood withdrawal.

公开(公告)号：US20040039324A1

公开(公告)日：2004-02-26

申请号：US10648233

申请日：2003-08-27

申请人： CHF Solutions, Inc.

发明人： Mark Gelfand ,  John J. O'Mahony ,  Howard R. Levin

IPC分类号： A61M037/00

CPC分类号： A61M1/34 ,  A61M1/1611 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3609 ,  A61M1/3639 ,  A61M1/367 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3344 ,  A61M2205/3375 ,  A61M2205/50 ,  A61M2230/20

摘要： A method and system for the extracorporeal treatment of blood to remove fluid from the fluid overloaded patient is disclosed that non-invasively measures osmotic pressure across a filter membrane of a blood filter. The filter is permeable to water and electrolytes, but not to blood protein. The osmotic pressure indicates the protein concentration in the blood. Osmotic pressure is used to detect when hypotension is about to occur in a patient, as a result of excessive blood volume reduction during treatment of the blood. Using the osmotic pressure measurement as a feedback signal, the rate of fluid extraction is automatically controlled to achieve the desired clinical outcome and avoid precipitating a hypotensive crisis in the patient.