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公开(公告)号：US20160024541A1
公开(公告)日：2016-01-28
申请号：US14820453
申请日：2015-08-06
发明人： Brian BRAZEAU , Jin-Sook Chang , Kwang Myung Cho , Young Wook Cho , Mervyn Desouza , Holly J. Jessen , So-Young Kim , Wei Niu , Fernando A. Sanchez-Riera , Yong-Uk Shin , Hyewon Um
CPC分类号： C12P13/12 , C12N9/1029 , C12N15/63 , C12N15/70 , C12N15/74 , C12Y203/01046 , Y02P20/52
摘要： Described herein are microorganisms that produce methionine and related products from endogenous genes in a transsulfuration pathway, as well as from exogenous genes providing a direct sulfhydrylation pathway. Novel genes that are useful for methionine and SAMe production are disclosed.
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2.发明申请NOVEL ISOLATED BACTERIOPHAGE HAVING E. COLI-SPECIFIC BACTERICIDAL ACTIVITY AND ANTIBACTERIAL COMPOSITION COMPRISING THE SAME 有权具有特异性杀菌活性的新型分离的细菌和包含其的抗菌组合物公开(公告)号：US20140356330A1
公开(公告)日：2014-12-04
申请号：US14345189
申请日：2012-11-14
发明人： Jae Won Kim , Young Wook Cho , Eun Mi Shin , Young Sa Kim , Si Yong Yang
IPC分类号： A61K35/76
CPC分类号： A61K35/76 , A23K20/147 , A23K50/30 , A23K50/60 , A23V2002/00 , A23V2200/32 , C12N7/00 , C12N2795/00021 , C12N2795/00032
摘要： The present invention relates to a novel bacteriophage having an E.-coli-specific bactericidal activity, a composition for the prevention or treatment of infectious diseases caused by Enterotoxigenic E.-coli comprising the bacteriophage as an active ingredient, an antibiotic comprising the bacteriophage as an active ingredient, a feed additive composition comprising the bacteriophage as an active ingredient, a sanitizer or cleaner comprising the bacteriophage as an active ingredient, and a method for treating colibacillosis using the bacteriophage. The novel bacteriophage of the present invention has a specific bactericidal activity against pathogenic E. coli, and excellent acid- and heat-resistance. Therefore, the novel bacteriophage can be used for the prevention or treatment of swine colibacillosis, which is an infectious disease caused by pathogenic E.-coli, and can also be widely used in animal feed additive compositions, sanitizers, and cleaners.
摘要翻译： 本发明涉及具有大肠杆菌特异性杀菌活性的新型噬菌体，用于预防或治疗由肠毒素型大肠杆菌引起的感染性疾病的组合物，其包含噬菌体作为活性成分，抗生素包含噬菌体为 活性成分，包含作为活性成分的噬菌体的饲料添加剂组合物，包含所述噬菌体作为活性成分的消毒剂或清洁剂，以及使用所述噬菌体治疗大肠杆菌病的方法。 本发明的新型噬菌体对致病性大肠杆菌具有特异杀菌活性，耐酸碱性优异。 因此，新型噬菌体可用于预防或治疗由大肠杆菌引起的感染性疾病的大肠杆菌病，也可广泛用于动物饲料添加剂组合物，消毒剂和清洁剂。
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公开(公告)号：US08846368B2
公开(公告)日：2014-09-30
申请号：US13621688
申请日：2012-09-17
发明人： Soo An Shin , Min Tae Park , Hyang Choi , Young Wook Cho , In Hye Kang , Su Jin Choi
CPC分类号： C12N7/00 , A01N63/00 , A61K35/76 , C12N2795/10311 , C12N2795/10321 , C12N2795/10331 , C12N2795/10332 , C12N2795/10351 , C12N2795/10371
摘要： Disclosed herein is a novel bacteriophage which has specific bactericidal activity against one or more Salmonella bacteria selected from the group consisting of Salmonella enteritidis, Salmonella typhimurium, Salmonella gallinarum, and Salmonella pullorum without affecting beneficial bacteria, in addition to showing excellent tolerance to acid, heat and desiccation. The novel bacteriophage of the present invention can be widely used as an active ingredient for therapeutic agents, animal feeds or drinking water, cleaners and sanitizers for preventing and treating the infectious diseases caused by Salmonella enteritidis, Salmonella typhimurium, Salmonella gallinarum or Salmonella pullorum including salmonellosis, Salmonella food poisoning, Fowl Typhoid, and Pullorum disease or for controlling the Salmonella bacteria. The present invention also provides important insights into prevention and control strategies against Salmonella infection and suggests that the use of bacteriophage can be a novel, safe, and effectively plausible alternative to antibiotics for the prevention of Salmonella infection in poultry.
摘要翻译： 本文公开了一种新型噬菌体，其对一种或多种选自肠炎沙门氏菌，鼠伤寒沙门氏菌，沙门氏菌和沙门氏菌的沙门菌细菌具有特异杀菌活性，而不影响有益细菌，除了显示对酸，热的良好耐受性 和干燥。 本发明的新型噬菌体可广泛用作治疗剂，动物饲料或饮用水，清洁剂和消毒剂，用于预防和治疗由肠炎沙门氏菌，鼠伤寒沙门氏菌，沙门氏菌或沙门氏菌包括沙门氏菌病引起的感染性疾病的活性成分 ，沙门氏菌食物中毒，家禽伤寒和Pullorum病或用于控制沙门氏菌。 本发明还提供了针对沙门氏菌感染的预防和控制策略的重要见解，并表明使用噬菌体可以是预防家禽沙门氏菌感染的抗生素的新颖，安全和有效的合理替代方法。
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公开(公告)号：US20140348799A1
公开(公告)日：2014-11-27
申请号：US14345642
申请日：2012-09-20
发明人： Si Yong Yang , Jae Won Kim , Young Wook Cho , Young Sa Kim , Eun Mi Shin
IPC分类号： A61K35/76
CPC分类号： A61K35/76 , A01N63/00 , A23K20/10 , A23K20/147 , A23K20/195 , A23K50/10 , A23K50/30 , A23K50/75 , C12N7/00 , C12N2795/10321 , C12N2795/10331 , C12N2795/10332 , C12R1/91
摘要： The present invention relates to a novel bacteriophage having a specific bactericidal activity against salmonella, a composition for the prevention or treatment of infectious diseases comprising the bacteriophage as an active ingredient, an antibiotic comprising the bacteriophage as an active ingredient, an animal feed or drinking water comprising the bacteriophage as an active ingredient, and a sanitizer or cleaner comprising the bacteriophage as an active ingredient. The novel bacteriophage of the present invention has a specific bactericidal activity against Salmonella choleraesuis, Salmonella typhimurium, Salmonella derby, Salmonella infantis or Salmonella newport with no influences on beneficial bacteria, as well as excellent acid- and heat-resistance and desiccation tolerance. Therefore, the novel bacteriophage can be used for the prevention or treatment of salmonellosis or salmonella food poisoning, which is an infectious disease caused by Salmonella choleraesuis, Salmonella typhimurium, Salmonella derby, Salmonella infantis or Salmonella newport, and also widely used in animal feeds, drinking water for livestock, sanitizers, and cleaners.
摘要翻译： 本发明涉及对沙门氏菌具有特异杀菌活性的新型噬菌体，用于预防或治疗感染性疾病的组合物，其包含作为活性成分的噬菌体，包含噬菌体作为活性成分的抗生素，动物饲料或饮用水 包括噬菌体作为活性成分，以及消毒剂或清洁剂，其包含所述噬菌体作为活性成分。 本发明的新型噬菌体具有对霍乱沙门氏菌，鼠伤寒沙门氏菌，沙门氏菌，婴幼儿沙门氏菌或沙门氏菌新港的特异杀菌活性，对有益菌无影响，以及优良的耐酸耐热性和干燥耐受性。 因此，新型噬菌体可用于预防或治疗沙门氏菌病或沙门氏菌食物中毒，这是由霍乱沙门氏菌，鼠伤寒沙门氏菌，沙门氏菌，沙门氏菌或沙门氏菌引起的感染性疾病，也广泛用于动物饲料， 为家畜，消毒剂和清洁剂饮用水。
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公开(公告)号：US20140017205A1
公开(公告)日：2014-01-16
申请号：US13621688
申请日：2012-09-17
发明人： Soo An Shin , Min Tae Park , Hyang Choi , Young Wook Cho , In Hye Kang , Su Jin Choi
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A01N63/00 , A61K35/76 , C12N2795/10311 , C12N2795/10321 , C12N2795/10331 , C12N2795/10332 , C12N2795/10351 , C12N2795/10371
摘要： Disclosed herein is a novel bacteriophage which has specific bactericidal activity against one or more Salmonella bacteria selected from the group consisting of Salmonella enteritidis, Salmonella typhimurium, Salmonella gallinarum, and Salmonella pullorum without affecting beneficial bacteria, in addition to showing excellent tolerance to acid, heat and desiccation. The novel bacteriophage of the present invention can be widely used as an active ingredient for therapeutic agents, animal feeds or drinking water, cleaners and sanitizers for preventing and treating the infectious diseases caused by Salmonella enteritidis, Salmonella typhimurium, Salmonella gallinarum or Salmonella pullorum including salmonellosis, Salmonella food poisoning, Fowl Typhoid, and Pullorum disease or for controlling the Salmonella bacteria. The present invention also provides important insights into prevention and control strategies against Salmonella infection and suggests that the use of bacteriophage can be a novel, safe, and effectively plausible alternative to antibiotics for the prevention of Salmonella infection in poultry.
摘要翻译： 本文公开了一种新型噬菌体，其对一种或多种选自肠炎沙门氏菌，鼠伤寒沙门氏菌，沙门氏菌和沙门氏菌的沙门菌细菌具有特异杀菌活性，而不影响有益细菌，除了显示对酸，热的良好耐受性 和干燥。 本发明的新型噬菌体可广泛用作治疗剂，动物饲料或饮用水，清洁剂和消毒剂，用于预防和治疗由肠炎沙门氏菌，鼠伤寒沙门氏菌，沙门氏菌或沙门氏菌包括沙门氏菌病引起的感染性疾病的活性成分 ，沙门氏菌食物中毒，家禽伤寒和Pullorum病或用于控制沙门氏菌。 本发明还提供了针对沙门氏菌感染的预防和控制策略的重要见解，并表明使用噬菌体可以是预防家禽沙门氏菌感染的抗生素的新颖，安全和有效的合理替代方法。
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公开(公告)号：US20130202643A1
公开(公告)日：2013-08-08
申请号：US13856563
申请日：2013-04-04
发明人： Hyang CHOI , Soo An Shin , Si Yong Yang , Young Wook Cho
IPC分类号： A61K39/112
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/552 , C07K14/255 , Y02A50/482
摘要： The present invention relates to avirulent Salmonella Gallinarum variants by inactivating virulence gene clusters of Salmonella Gallinarum (SG), a main pathogen of avian salmonellosis, and various uses thereof notably in the production of Salmonella-specific lytic bacteriophages, pharmaceutical compositions and feed additives.
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公开(公告)号：US10166264B2
公开(公告)日：2019-01-01
申请号：US15249234
申请日：2016-08-26
发明人： Si Yong Yang , Jae Won Kim , Young Wook Cho , Young Sa Kim , Eun Mi Shin
IPC分类号： A61K35/76 , A23K20/147 , A23K20/10 , A23K20/195 , A23K50/10 , A23K50/30 , A23K50/75 , C12N7/00 , C12R1/92 , A01N63/00 , C12R1/91
摘要： The present invention relates to a bacteriophage having a specific bactericidal activity against Salmonella, a composition for the prevention or treatment of infectious diseases comprising the bacteriophage as an active ingredient, an antibiotic comprising the bacteriophage as an active ingredient, an animal feed or drinking water comprising the bacteriophage as an active ingredient, and a sanitizer or cleaner comprising the bacteriophage as an active ingredient. The bacteriophage of the present invention has a specific bactericidal activity against Salmonella choleraesuis, Salmonella typhimurium, Salmonella derby, Salmonella infantis or Salmonella newport with no influences on beneficial bacteria, as well as excellent acid- and heat-resistance and desiccation tolerance.
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8.发明授权Avirulent Salmonella gallinarum variants and pharmaceutical composition using the same 有权无毒性沙门氏菌变种和使用其的药物组合物公开(公告)号：US09192658B2
公开(公告)日：2015-11-24
申请号：US13856563
申请日：2013-04-04
发明人： Hyang Choi , Soo An Shin , Si Yong Yang , Young Wook Cho
IPC分类号： A61K39/112 , C12N1/20 , C07K14/255 , A61K39/00
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/552 , C07K14/255 , Y02A50/482
摘要： The present invention relates to avirulent Salmonella Gallinarum variants by inactivating virulence gene clusters of Salmonella Gallinarum (SG), a main pathogen of avian salmonellosis, and various uses thereof notably in the production of Salmonella-specific lytic bacteriophages, pharmaceutical compositions and feed additives.
摘要翻译： 本发明涉及无毒性沙门氏菌变种，其通过灭活禽沙门氏菌病的主要病原体沙门氏菌（SG）的毒力基因簇，以及其特别用于产生沙门氏菌特异性裂解噬菌体，药物组合物和饲料添加剂的各种用途。
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公开(公告)号：US20130260424A1
公开(公告)日：2013-10-03
申请号：US13832462
申请日：2013-03-15
发明人： Brian BRAZEAU , Jin-Sook Chang , Kwang Myung Cho , Young Wook Cho , Mervyn Desouza , Holly J. Jessen , So-Young Kim , Wei Niu , Fernando A. Sanchez-Reira , Yong-Uk Shin , Hyewon Um
IPC分类号： C12P13/12
CPC分类号： C12P13/12 , C12N9/1029 , C12N15/63 , C12N15/70 , C12N15/74 , C12Y203/01046 , Y02P20/52
摘要： Described herein are microorganisms that produce methionine and related products from endogenous genes in a transsulfuration pathway, as well as from exogenous genes providing a direct sulfhydrylation pathway. Novel genes that are useful for methionine and SAMe production are disclosed.
摘要翻译： 这里描述的是从转基因途径中的内源基因以及提供直接巯基化途径的外源基因产生甲硫氨酸和相关产物的微生物。 公开了可用于甲硫氨酸和SAMe生产的新型基因。
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公开(公告)号：US20130022579A1
公开(公告)日：2013-01-24
申请号：US13621730
申请日：2012-09-17
发明人： In Hye Kang , Min Tae Park , Young Wook Cho , Soo An Shin , Hyang Choi
CPC分类号： A61K35/76 , A23K10/18 , A23K50/75 , C12N2795/10332
摘要： The present invention relates to a novel bacteriophage, more particularly, a bacteriophage that has a specific bactericidal activity against Salmonella typhimurium, Salmonella gallinarum, or Salmonella pullorum, a composition for the prevention or treatment of infectious diseases including salmonellosis and Salmonella food poisoning caused by Salmonella typhimurium, Fowl typhoid caused by Salmonella gallinarum, and Pullorum disease caused by Salmonella pullorum, which comprises the bacteriophage as an active ingredient, and an animal feed, drinking water, cleaner, and sanitizer which comprise the bacteriophage as an active ingredient. The present invention also provides important insights into prevention and control strategies against Salmonella infection and suggests that the use of bacteriophage can be a novel, safe, and effectively plausible alternative to antibiotics for the prevention of Salmonella infection in poultry.
摘要翻译： 本发明涉及一种新的噬菌体，更具体地说，涉及对鼠伤寒沙门氏菌，沙门氏菌或沙门氏菌具有特异杀菌活性的噬菌体，用于预防或治疗由沙门氏菌引起的沙门氏菌病和沙门氏菌食物中毒的传染病的组合物 鼠伤寒沙门氏菌引起的家禽伤寒，以及包含噬菌体作为活性成分的沙门氏菌引起的白花病，以及包含噬菌体作为活性成分的动物饲料，饮用水，清洁剂和消毒剂。 本发明还提供了针对沙门氏菌感染的预防和控制策略的重要见解，并表明使用噬菌体可以是预防家禽沙门氏菌感染的抗生素的新颖，安全和有效的合理替代方法。
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