公开(公告)号：US20210403535A1

公开(公告)日：2021-12-30

申请号：US17474434

申请日：2021-09-14

申请人： COLZYX AB

发明人： Matthias MÖRGELIN ,  Suado ABDILLAHI

IPC分类号： C07K14/78 ,  A61L27/54 ,  A61L15/44 ,  C07K14/47 ,  A61P17/02 ,  A61P31/04 ,  A01N47/44 ,  A61L15/32 ,  A61L17/00 ,  A61L17/14 ,  A61L24/00 ,  A61L24/10 ,  A61L27/22 ,  A61L27/24 ,  A61L27/34 ,  A61L27/60 ,  A61L29/04 ,  A61L29/08 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  C07K14/755

摘要： The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from collagen type VI or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof, wherein the polypeptide, fragment, variant, fusion or derivative is capable of killing or attenuating the growth of microorganisms. Related aspects of the invention provide corresponding isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of microbial infections and in wound care. Also provided are a method of killing microorganisms in vitro and a medical device associated with the pharmaceutical composition.

公开(公告)号：US20190023767A1

公开(公告)日：2019-01-24

申请号：US16066912

申请日：2017-01-20

申请人： COLZYX AB

发明人： Matthias MÖRGELIN ,  Suado ABDILLAHI

IPC分类号： C07K14/78 ,  C07K14/755 ,  A61K9/00 ,  A61L31/16 ,  A61L31/10 ,  A61L31/04 ,  A61L29/16 ,  A61L29/08 ,  A61L29/04 ,  A61L27/54 ,  A61L27/60 ,  A61L27/34 ,  A61L27/24 ,  A61L27/22 ,  A61L24/10 ,  A61L24/00 ,  A61L17/00 ,  A61L17/14 ,  A61L15/44 ,  A61L15/32 ,  A61P31/04 ,  A01N47/44 ,  A61P17/02

CPC分类号： C07K14/78 ,  A01N47/44 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/7023 ,  A61K38/00 ,  A61L15/32 ,  A61L15/325 ,  A61L15/44 ,  A61L17/005 ,  A61L17/145 ,  A61L24/0015 ,  A61L24/102 ,  A61L24/108 ,  A61L27/227 ,  A61L27/24 ,  A61L27/34 ,  A61L27/54 ,  A61L27/60 ,  A61L29/045 ,  A61L29/048 ,  A61L29/085 ,  A61L29/16 ,  A61L31/044 ,  A61L31/047 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2420/00 ,  A61L2430/34 ,  A61P17/02 ,  A61P31/04 ,  C07K14/4723 ,  C07K14/755 ,  C07K2319/00

摘要： The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from collagen type VI or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof, wherein the polypeptide, fragment, variant, fusion or derivative is capable of killing or attenuating the growth of microorganisms. Related aspects of the invention provide corresponding isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of microbial infections and in wound care. Also provided are a method of killing microorganisms in vitro and a medical device associated with the pharmaceutical composition.

公开(公告)号：US20240043500A1

公开(公告)日：2024-02-08

申请号：US18483108

申请日：2023-10-09

申请人： COLZYX AB

发明人： Matthias MÖRGELIN ,  Suado ABDILLAHI

IPC分类号： C07K14/78 ,  A61L27/54 ,  A61L15/44 ,  C07K14/47 ,  A61P17/02 ,  A61P31/04 ,  A01N47/44 ,  A61L15/32 ,  A61L17/00 ,  A61L17/14 ,  A61L24/00 ,  A61L24/10 ,  A61L27/22 ,  A61L27/24 ,  A61L27/34 ,  A61L27/60 ,  A61L29/04 ,  A61L29/08 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  C07K14/755

CPC分类号： C07K14/78 ,  A61L27/54 ,  A61L15/44 ,  C07K14/4723 ,  A61P17/02 ,  A61P31/04 ,  A01N47/44 ,  A61L15/32 ,  A61L15/325 ,  A61L17/005 ,  A61L17/145 ,  A61L24/0015 ,  A61L24/102 ,  A61L24/108 ,  A61L27/227 ,  A61L27/24 ,  A61L27/34 ,  A61L27/60 ,  A61L29/045 ,  A61L29/048 ,  A61L29/085 ,  A61L29/16 ,  A61L31/044 ,  A61L31/047 ,  A61L31/10 ,  A61L31/16 ,  C07K14/755 ,  A61L2300/404 ,  A61K9/7023

摘要： The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from collagen type VI or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof, wherein the polypeptide, fragment, variant, fusion or derivative is capable of killing or attenuating the growth of microorganisms. Related aspects of the invention provide corresponding isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of microbial infections and in wound care. Also provided are a method of killing microorganisms in vitro and a medical device associated with the pharmaceutical composition.