-
1.发明申请Endless Fibres on the Basis of Hyaluronan Selectively Oxidized in the Position 6 of the N-Acetyl-D-Glucosamine Group, Preparation and Use Thereof, Threads, Staples, Yarns, Fabrics Made Thereof and Method for Modifying the Same 审中-公开在N-乙酰基-D-氨基葡糖胺基团的位置6中选择性氧化的透明质酸基础上的无限纤维，其制备和使用，其制造的线，钉子，纱线，织物及其修饰方法公开(公告)号：US20150299911A1
公开(公告)日：2015-10-22
申请号：US14647595
申请日：2013-11-26
发明人： Jiri Betak , Radovan Buffa , Miroslava Nemcova , Tomas Pitucha , Jaromir Kulhanek , Ilona Matejkova , Jana Novakova , Lucie Vistejnova , Pavel Klein , Gabriela Kubickova , Marketa Broulikova , Michaela Felgrova , Vladimir Velebny
CPC分类号： D01F11/00 , A61L27/20 , A61L27/50 , C08B37/0072 , C08L5/08 , D01D5/06 , D01F9/00 , D03D3/02 , D03D25/00 , D04H13/00 , D06M13/144 , D06M13/422 , D06M23/10 , D10B2331/06
摘要： The present invention relates to the preparation of textile processable endless monofilaments and multifilaments on the basis of hyaluronan which has been selectively oxidized to aldehyde in the position 6 of its/V-acetyl-D-glucosamine group and to the subsequent modification of such filaments with low molecular dihydrazides. The fibres as well as the fabrics, which are subsequently prepared from the former, exhibit a time-varying solubility in saline depending on the external modification of the fibres. After having been externally modified, the fibres as well as the fabrics exhibit a prolong period of transition into an evenly distributed gel layer. The externally modified fibrous materials retain their full biocompatibility.
摘要翻译： 本发明涉及以透明质酸为基础的可纺加工无端单丝和复丝的制备方法，该透明质酸已经在其N-乙酰基-D-葡糖胺基团的位置6选择性氧化成醛， 低分子二酰肼。 随后由前者制备的纤维以及织物随着纤维的外部改性而在盐水中表现出时变的溶解性。 在经过外部改性之后，纤维以及织物表现出延长的过渡到均匀分布的凝胶层的时间段。 外部改性的纤维材料保持其完全的生物相容性。
-
2.发明申请C6-C18-Acylated Derivative of Hyaluronic Acid, Method of Preparation Thereof, Nanomicellar Composition on its Basis, Method of Preparation Thereof and Method of Preparation Stabilized Nanomicellar Composition, and Use Thereof 有权透明质酸的C6-C18-酰基化衍生物，其制备方法，其基础上的纳米组合物的制备方法和制备方法稳定的纳米组合物及其用途公开(公告)号：US20150320873A1
公开(公告)日：2015-11-12
申请号：US14647626
申请日：2013-11-26
发明人： Daniela Smejkalova , Gloria Huerta-Angeles , Martin Bobek , Martina Hermannova , Lucie Vistejnova , Jaroslav Novotny , Eva Prikopova , Kristina Nesporova , Miroslava Nemcova , Klara Slezingrova , Jaromir Kulhanek , Dagmar Cozikova , Jana Sogorkova , Jan Kucera , Pavel Klein , Vladimir Velebny
IPC分类号： A61K47/48 , A61K31/355 , A61K31/337 , A61K31/685 , A61Q19/00 , A61K36/185 , C08K3/30 , C08J3/24 , A61K8/02 , A61K8/73 , C08B37/08 , A61K31/122
CPC分类号： A61K47/61 , A61K8/0291 , A61K8/735 , A61K9/1075 , A61K31/122 , A61K31/337 , A61K31/355 , A61K31/685 , A61K36/00 , A61K47/36 , A61K47/6907 , A61K2800/10 , A61K2800/413 , A61K2800/56 , A61Q19/00 , C08B37/0072 , C08K3/30 , C08K2003/3045
摘要： The invention relates to a method of preparation hydrophobized hyaluronic acid (Formula I) and further to a method of encapsulating biologically active substances into the nanomicelles of hydrophobized hyaluronan serving as carriers of biologically active hydrophobic substances. The hydrophobization of hyaluronan is carried out through an esterification reaction of hyaluronan with long-chain carboxylic acids, the latter being activated by a halogenide derivative of 2,4,6-trichlorobenzoic acid or by another organic chloride. In an aqueous environment, water-soluble hydrophobized derivatives can form nanomicelles in which nonpolar substances can be bound by means of non-covalent physical interactions. The core of a nanomicelle is formed by hydrophobic acyl functional groups while the shell of a nanomicelle is formed by hyaluronic acid. The encapsulation of the substances into nanomicelles can be performed by means of the solvent exchange method or by means of sonication. Hyaluronic nanomicelles support the penetration of bound substances in topical applications and enable the bound substances to be transferred into the individual cells. The nanomicelles obtained from hydrophobized hyaluronan derivatives are usable in cosmetic and pharmaceutical applications.
摘要翻译： 本发明涉及一种制备疏水化透明质酸（式I）的方法，还涉及一种将生物活性物质包封在作为生物活性疏水物质的载体的疏水化透明质酸的纳米胶囊中的方法。 透明质酸的疏水化通过透明质酸与长链羧酸的酯化反应进行，后者由2,4,6-三氯苯甲酸的卤化物衍生物或另一种有机氯化物活化。 在水性环境中，水溶性疏水化衍生物可以形成纳米胶束，其中非极性物质可以通过非共价物理相互作用结合。 纳米胶束的核心由疏水性酰基官能团形成，而纳米胶束的壳由透明质酸形成。 可以通过溶剂交换法或通过超声处理将物质包封在纳米胶束中。 透明质酸纳米胶囊支持局部应用中结合物质的渗透，并使结合物质转移到单个细胞中。 从疏水化透明质酸衍生物获得的纳米胶囊可用于化妆品和药物应用。
-
公开(公告)号：US09999678B2
公开(公告)日：2018-06-19
申请号：US14647626
申请日：2013-11-26
发明人： Daniela Smejkalova , Gloria Huerta-Angeles , Martin Bobek , Martina Hermannova , Lucie Vistejnova , Jaroslav Novotny , Eva Prikopova , Kristina Nesporova , Miroslava Nemcova , Klara Slezingrova , Jaromir Kulhanek , Dagmar Cozikova , Jana Sogorkova , Jan Kucera , Pavel Klein , Vladimir Velebny
IPC分类号： A61K31/728 , C08B37/08 , A61K47/48 , A61K31/355 , A61K31/337 , A61K31/685 , A61K31/122 , C08K3/30 , A61K8/02 , A61K8/73 , A61Q19/00 , A61K47/36 , A61K9/107 , A61K47/69 , A61K36/00
CPC分类号： A61K47/61 , A61K8/0291 , A61K8/735 , A61K9/1075 , A61K31/122 , A61K31/337 , A61K31/355 , A61K31/685 , A61K36/00 , A61K47/36 , A61K47/6907 , A61K2800/10 , A61K2800/413 , A61K2800/56 , A61Q19/00 , C08B37/0072 , C08K3/30 , C08K2003/3045
摘要： The invention relates to a method of preparation hydrophobized hyaluronic acid (Formula I) and further to a method of encapsulating biologically active substances into the nanomicelles of hydrophobized hyaluronan serving as carriers of biologically active hydrophobic substances. The hydrophobization of hyaluronan is carried out through an esterification reaction of hyaluronan with long-chain carboxylic acids, the latter being activated by a halogenide derivative of 2,4,6-trichlorobenzoic acid or by another organic chloride. In an aqueous environment, water-soluble hydrophobized derivatives can form nanomicelles in which nonpolar substances can be bound by means of non-covalent physical interactions. The core of a nanomicelle is formed by hydrophobic acyl functional groups while the shell of a nanomicelle is formed by hyaluronic acid. The encapsulation of the substances into nanomicelles can be performed by means of the solvent exchange method or by means of sonication. Hyaluronic nanomicelles support the penetration of bound substances in topical applications and enable the bound substances to be transferred into the individual cells. The nanomicelles obtained from hydrophobized hyaluronan derivatives are usable in cosmetic and pharmaceutical applications.
-
-
搜索结果
3 条记录 (耗时 0.014 秒)
