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1.发明申请Method for production of n-butanol from syngas using syntrophic co-cultures of anaerobic microorganisms 有权使用厌氧微生物的合成共培养物从合成气生产正丁醇的方法公开(公告)号：US20140206052A1
公开(公告)日：2014-07-24
申请号：US13745155
申请日：2013-01-18
Applicant: COSKATA, INC.
Inventor： Mike Enzien , Rathin Datta , Richard Tobey
IPC: C12P7/16
Abstract: This invention provides methods and systems for the production of butanol. Specifically, the methods and systems of the present invention use syntrophic co-cultures for the production of butanol from syngas.
Abstract translation: 本发明提供了生产丁醇的方法和系统。 具体地，本发明的方法和系统使用合成共培养物从合成气生产丁醇。
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2.发明授权Method for production of n-butanol from syngas using syntrophic co-cultures of anaerobic microorganisms 有权使用厌氧微生物的合成共培养物从合成气生产正丁醇的方法公开(公告)号：US09469860B2
公开(公告)日：2016-10-18
申请号：US13745155
申请日：2013-01-18
Applicant: Coskata, Inc.
Inventor： Mike Enzien , Rathin Datta , Richard Tobey
Abstract: This invention provides methods and systems for the production of butanol. Specifically, the methods and systems of the present invention use syntrophic co-cultures for the production of butanol from syngas.
Abstract translation: 本发明提供了生产丁醇的方法和系统。 具体地，本发明的方法和系统使用合成共培养物从合成气生产丁醇。
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公开(公告)号：US09284538B2
公开(公告)日：2016-03-15
申请号：US14083007
申请日：2013-11-18
Applicant: Coskata, Inc.
Inventor： Andrew Reeves , Rathin Datta
CPC classification number: C12N9/1029 , C12N9/1217 , C12N15/52 , C12N15/74 , C12P7/065 , Y02E50/17
Abstract: Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established. Key genes of interest for metabolic catalyzing activity in clostridial species include a three-gene operon coding for CODH activity, a two-gene operon coding for PTA-ACK, and a novel acetyl coenzyme A reductase. The promoter regions of the two operons and the acetyl coA reductase are manipulated to increase ethanol production.
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Patent Agency Ranking
4.发明申请Syntrophic co-culture of anaerobic microorganism for production of n-butanol from syngas 审中-公开用于从合成气生产正丁醇的厌氧微生物的合成共培养物公开(公告)号：US20150322402A1
公开(公告)日：2015-11-12
申请号：US14812182
申请日：2015-07-29
Applicant: Coskata, Inc.
Inventor： Rathin Datta , Andrew Reeves
Abstract: This invention provides compositions for the production of butanol. Specifically, the compositions of the present invention use syntrophic co-cultures for the production of butanol from syngas.
Abstract translation: 本发明提供了用于生产丁醇的组合物。 具体地，本发明的组合物使用合成共培养物从合成气生产丁醇。
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5.发明申请公开(公告)号：US20140228598A1
公开(公告)日：2014-08-14
申请号：US13942311
申请日：2013-07-15
Applicant: COSKATA, INC.
Inventor： Rathin Datta , Steve Calderone , Loula Sassaris Merkel
IPC: C12P7/06
CPC classification number: C12P7/04 , C12P7/065 , C12P7/08 , C12P7/16 , Y02E50/10 , Y02E50/17 , Y02E50/343 , Y02E50/346 , Y02P20/125
Abstract: Integrated processes are disclosed for reducing the carbon foot print related to the use of non-renewable hydrocarbon gas streams for producing alcohols by anaerobic bioconversion of reformed gas. These processes combine renewable and non-renewable gas sources of hydrogen, carbon monoxide and carbon dioxide to produce alcohol. Thus the invention found a highly a practical way to make use of non-renewable carbon oxide sources while still lowering the carbon footprint of such alcohols produced thereby, especially when combined with corn ethanol production. In the case of motor fuel use, the renewable portion of the alcohol produced in this manner provides a reduction in greenhouse gases by 50% or more when compared to gasoline.
Abstract translation: 公开了一种综合方法，用于通过改性气体的厌氧生物转化来减少与用于生产醇的不可再生烃气流相关的碳脚印。 这些方法将可再生和不可再生气体的氢气，一氧化碳和二氧化碳组合起来生产酒精。 因此，本发明发现使用不可再生碳氧化物源的高度实用的方法，同时仍然降低由此产生的这种醇的碳足迹，特别是当与玉米乙醇生产相结合时。 在使用机动车燃料的情况下，与汽油相比，以这种方式生产的醇的可再生部分使温室气体减少了50％以上。
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6.发明申请MEMBRANE SUPPORTED BIOREACTOR FOR CONVERSION OF SYNGAS COMPONENTS TO LIQUID PRODUCTS 审中-公开用于转换液体产品的SYNGAS组分的膜支持生物反应器公开(公告)号：US20140377822A1
公开(公告)日：2014-12-25
申请号：US14481746
申请日：2014-09-09
Applicant: Coskata, Inc.
Inventor： Robert Hickey , Rathin Datta , Shih-Perng Tsai , Rahul Basu
IPC: C12P7/06
CPC classification number: C12P7/065 , C12M21/12 , C12M23/58 , C12M25/10 , C12M29/16 , C12M41/28 , C12P7/04 , Y02E50/17
Abstract: Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO2 and H2 with a surface of a membrane under anaerobic conditions and transferring these components into contact with a biofilm on the opposite side of the membrane. These steps provide a stable system for producing liquid products such as ethanol, butanol and other chemicals. The gas fed on the membrane's gas contact side transports through the membrane to form a biofilm of anaerobic microorganisms that converted the syngas to desired liquid products. The system can sustain production with a variety of microorganisms and membrane configurations.
Abstract translation: 乙醇和其它液体产物是通过将合成气组分如CO或CO 2和H 2的混合物与膜的表面在厌氧条件下接触而生产的，并将这些组分与膜的相反侧的生物膜接触。 这些步骤为生产液体产品如乙醇，丁醇和其他化学品提供了稳定的系统。 供给在膜的气体接触侧的气体输送通过膜以形成将合成气转化为所需液体产物的厌氧微生物生物膜。 该系统可以通过各种微生物和膜结构来维持生产。
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7.发明申请Syntrophic co-culture of anaerobic microorganism for production of n-butanol from syngas 审中-公开用于从合成气生产正丁醇的厌氧微生物的合成共培养物公开(公告)号：US20140206066A1
公开(公告)日：2014-07-24
申请号：US13745177
申请日：2013-01-18
Applicant: COSKATA, INC.
Inventor： Rathin Datta , Andrew Reeves
Abstract: This invention provides compositions for the production of butanol. Specifically, the compositions of the present invention use syntrophic co-cultures for the production of butanol from syngas.
Abstract translation: 本发明提供了用于生产丁醇的组合物。 具体地说，本发明的组合物使用合成共培养物从合成气生产丁醇。
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8.发明申请Genes Encoding Key Catalyzing Mechanisms for Ethanol Production From Syngas Fermentation 有权编码合成气发酵乙醇生产关键催化机理的基因公开(公告)号：US20140206054A1
公开(公告)日：2014-07-24
申请号：US14083007
申请日：2013-11-18
Applicant: Coskata, Inc.
Inventor： Andrew Reeves , Rathin Datta
CPC classification number: C12N9/1029 , C12N9/1217 , C12N15/52 , C12N15/74 , C12P7/065 , Y02E50/17
Abstract: Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established. Key genes of interest for metabolic catalyzing activity in clostridial species include a three-gene operon coding for CODH activity, a two-gene operon coding for PTA-ACK, and a novel acetyl coenzyme A reductase. The promoter regions of the two operons and the acetyl coA reductase are manipulated to increase ethanol production.
Abstract translation: 对重要的乙型梭菌种的基因序列进行测序和分离。 确定了感兴趣的基因，建立了功能。 梭菌中代谢催化活性的关键基因包括编码CODH活性的三基因操纵子，编码PTA-ACK的双基因操纵子和新型乙酰辅酶A还原酶。 操纵两个操纵子的启动子区域和乙酰辅酶A还原酶以增加乙醇生成。
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