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公开(公告)号：US09428755B2
公开(公告)日：2016-08-30
申请号：US14592208
申请日：2015-01-08
Applicant: Coskata, Inc.
Inventor： Andrew Reeves
CPC classification number: C12N15/74 , C12N9/1007 , C12N15/63 , C12N15/70 , C12N15/87 , C12Q2521/331 , C12Y201/01072
Abstract: This invention provides isolated polynucleotides encoding DNA Type I methyltransferase and uses thereof for improving transformation efficiencies of exogenous and endogenous plasmid DNA into Clostridial hosts.
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公开(公告)号：US09284538B2
公开(公告)日：2016-03-15
申请号：US14083007
申请日：2013-11-18
Applicant: Coskata, Inc.
Inventor： Andrew Reeves , Rathin Datta
CPC classification number: C12N9/1029 , C12N9/1217 , C12N15/52 , C12N15/74 , C12P7/065 , Y02E50/17
Abstract: Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established. Key genes of interest for metabolic catalyzing activity in clostridial species include a three-gene operon coding for CODH activity, a two-gene operon coding for PTA-ACK, and a novel acetyl coenzyme A reductase. The promoter regions of the two operons and the acetyl coA reductase are manipulated to increase ethanol production.
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3.发明申请Syntrophic co-culture of anaerobic microorganism for production of n-butanol from syngas 审中-公开用于从合成气生产正丁醇的厌氧微生物的合成共培养物公开(公告)号：US20150322402A1
公开(公告)日：2015-11-12
申请号：US14812182
申请日：2015-07-29
Applicant: Coskata, Inc.
Inventor： Rathin Datta , Andrew Reeves
Abstract: This invention provides compositions for the production of butanol. Specifically, the compositions of the present invention use syntrophic co-cultures for the production of butanol from syngas.
Abstract translation: 本发明提供了用于生产丁醇的组合物。 具体地，本发明的组合物使用合成共培养物从合成气生产丁醇。
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公开(公告)号：US20150191736A1
公开(公告)日：2015-07-09
申请号：US14592208
申请日：2015-01-08
Applicant: Coskata, Inc.
Inventor： Andrew Reeves
CPC classification number: C12N15/74 , C12N9/1007 , C12N15/63 , C12N15/70 , C12N15/87 , C12Q2521/331 , C12Y201/01072
Abstract: This invention provides isolated polynucleotides encoding DNA Type I methyltransferase and uses thereof for improving transformation efficiencies of exogenous and endogenous plasmid DNA into Clostridial hosts.
Abstract translation: 本发明提供编码DNA I型甲基转移酶的分离的多核苷酸及其用于提高外源和内源质粒DNA转化成梭菌宿主的转化效率的用途。
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公开(公告)号：US09045758B2
公开(公告)日：2015-06-02
申请号：US14209634
申请日：2014-03-13
Applicant: Coskata, Inc.
Inventor： Andrew Reeves
CPC classification number: C12N15/74 , C12N9/1007 , C12N15/63 , C12N15/70 , C12N15/87 , C12Q2521/331 , C12Y201/01072
Abstract: This invention provides isolated polynucleotides encoding DNA Type I methyltransferase and uses thereof for improving transformation efficiencies of exogenous and endogenous plasmid DNA into Clostridial hosts.
Abstract translation: 本发明提供编码DNA I型甲基转移酶的分离的多核苷酸及其用于提高外源和内源质粒DNA转化成梭菌宿主的转化效率的用途。
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Patent Agency Ranking
6.发明申请Syntrophic co-culture of anaerobic microorganism for production of n-butanol from syngas 审中-公开用于从合成气生产正丁醇的厌氧微生物的合成共培养物公开(公告)号：US20140206066A1
公开(公告)日：2014-07-24
申请号：US13745177
申请日：2013-01-18
Applicant: COSKATA, INC.
Inventor： Rathin Datta , Andrew Reeves
Abstract: This invention provides compositions for the production of butanol. Specifically, the compositions of the present invention use syntrophic co-cultures for the production of butanol from syngas.
Abstract translation: 本发明提供了用于生产丁醇的组合物。 具体地说，本发明的组合物使用合成共培养物从合成气生产丁醇。
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7.发明申请Genes Encoding Key Catalyzing Mechanisms for Ethanol Production From Syngas Fermentation 有权编码合成气发酵乙醇生产关键催化机理的基因公开(公告)号：US20140206054A1
公开(公告)日：2014-07-24
申请号：US14083007
申请日：2013-11-18
Applicant: Coskata, Inc.
Inventor： Andrew Reeves , Rathin Datta
CPC classification number: C12N9/1029 , C12N9/1217 , C12N15/52 , C12N15/74 , C12P7/065 , Y02E50/17
Abstract: Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established. Key genes of interest for metabolic catalyzing activity in clostridial species include a three-gene operon coding for CODH activity, a two-gene operon coding for PTA-ACK, and a novel acetyl coenzyme A reductase. The promoter regions of the two operons and the acetyl coA reductase are manipulated to increase ethanol production.
Abstract translation: 对重要的乙型梭菌种的基因序列进行测序和分离。 确定了感兴趣的基因，建立了功能。 梭菌中代谢催化活性的关键基因包括编码CODH活性的三基因操纵子，编码PTA-ACK的双基因操纵子和新型乙酰辅酶A还原酶。 操纵两个操纵子的启动子区域和乙酰辅酶A还原酶以增加乙醇生成。
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8.发明授权Methods for sustaining the viability of acetogens during a decrease or cessation of syngas flow 有权在合成气流减少或停止期间维持乙酰菌的活力的方法公开(公告)号：US09464302B2
公开(公告)日：2016-10-11
申请号：US14327165
申请日：2014-07-09
Applicant: Coskata, Inc.
Inventor： Robert Hickey , Andrew Reeves
Abstract: The methods are disclosed for sustaining a population of microorganisms in an aqueous fermentation broth used in a process to convert syngas to alcohol when the supply of syngas is decreased or ceased. The methods involve supplying at least one reducible anion in a rate an amount sufficient to maintain the population of microorganisms.
Abstract translation: 公开了用于在合成气的供应减少或停止时在用于将合成气转化为醇的方法中使用的水性发酵液中维持微生物群的方法。 所述方法包括以足以维持微生物群体的量提供至少一种可还原阴离子。
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9.发明申请Essential Genes Encoding Conserved Metabolic Pathway Function in Autotrophic Solventogenic Clostridial Species 审中-公开编码保护性代谢途径功能的自身致病性梭菌物种的基本基因公开(公告)号：US20150191749A1
公开(公告)日：2015-07-09
申请号：US14665894
申请日：2015-03-23
Applicant: Coskata, Inc.
Inventor： Andrew Reeves , Fenglin Yin
CPC classification number: C12P7/06 , C12N9/0008 , C12N15/52 , C12P7/065 , C12Y102/02004 , Y02E50/17
Abstract: Essential genes coding for the metabolic pathway of solventogenic autotrophic Clostridia were sequenced, and functionality was confirmed. The present invention utilizes a comparative inter-species approach to develop the minimum set of essential genes for metabolic function and estimate productivity in species of suspected solventogenic capability.
Abstract translation: 编码溶剂性自养型梭菌代谢途径的基本基因进行了测序，确定了功能。 本发明利用比较物种间方法来开发用于代谢功能的必需基因的最小集合，并估计疑似溶剂生成能力的物种的生产力。
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10.发明授权Processes for the anaerobic bioconverison of syngas to oxygenated organic compound with in situ protection from hydrogen cyanide 有权合成气对含氧有机化合物的厌氧生物反应的过程，原位保护不受氰化氢的影响公开(公告)号：US09034617B2
公开(公告)日：2015-05-19
申请号：US13828542
申请日：2013-03-14
Applicant: COSKATA, INC.
Inventor： Robert Hickey , Jianxin Du , Andrew Reeves , Richard E. Tobey
CPC classification number: C12P7/16 , C12N1/20 , C12N1/38 , C12P7/04 , C12P7/06 , Y02E50/10 , Y02E50/17
Abstract: Processes are disclosed for the anaerobic bioconversion of syngas to oxygenated organic compound that use an in situ method for protecting the microorganisms from hydrogen cyanide contained in the syngas that passes to the fermentation broth. The fermentation broth is maintained at a pH of between about 4 and 6, and dissolved metal cation of one or more of iron, cobalt, nickel and zinc is provided to the fermentation broth in an amount sufficient to form, under the conditions of the fermentation broth, a substantially insoluble metal complex with the metal cation and cyanide anion. The rate of formation of the insoluble complex is sufficiently high that that the amount of cyanide that is taken up by microorganisms does not result in an undue adverse effect on the population of microorganisms.
Abstract translation: 公开了将合成气厌氧生物转化为含氧有机化合物的方法，其使用原位方法保护微生物免受通过发酵液的合成气中所含的氰化氢。 发酵液的pH值保持在4〜6左右之间，并在发酵液中提供一种或多种铁，钴，镍，锌溶解的金属阳离子，其量足以在发酵条件下形成 肉汤，与金属阳离子和氰化物阴离子基本不溶的金属络合物。 不溶性络合物的形成速率足够高，使得微生物吸收的氰化物的量不会对微生物群体产生不适当的不利影响。
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