公开(公告)号：US20250067258A1

公开(公告)日：2025-02-27

申请号：US18847659

申请日：2023-04-12

Applicant: CYTIVA SWEDEN AB

Inventor： Andreas Lundin ,  Christopher Ford ,  Klaus Gebauer ,  Per Stromberg

IPC: F04B43/073 ,  F04B43/00 ,  F04B53/16

Abstract: The present disclosure relates to a pump (100, 1100, 2100) for providing substantially continuous liquid flow in a bioprocessing system (200), the pump (100, 1100, 2100) comprising: a pressurisable outlet chamber (122, 1122) in fluidic communication with an outlet (126, 1126, 2126) of the pump (100, 1100, 2100); and a pressurisable feed chamber (120, 1120) connected in series with the outlet chamber (122, 1122), wherein the feed chamber (120, 1120) is configured to fill the outlet chamber (122, 1122) during discharge of liquid from the outlet chamber (122, 1122).

公开(公告)号：US20220275798A1

公开(公告)日：2022-09-01

申请号：US17634455

申请日：2020-06-24

Applicant: Cytiva Sweden AB

Inventor： Klaus Gebauer ,  Andreas Lundin ,  Andreas Marcstrom ,  David Gronowitz ,  Bjorn Johansson ,  Mats Nilsson ,  Bjorn Olovsson

IPC: F04B43/02 ,  F04B53/10 ,  F04B43/00

Abstract: A diapharagm pump for a bioprocess system comprises a pump head (1; 101; 201; 301) comprising: a common inlet (3); a common outlet (5); a plurality of pump cavities (7) each including at least one cooperating pair of one-way valves, the at least one pair of one-way valves including an inlet valve (9) and an outlet valve (11), wherein the respective inlet valves (9) are in fluid communication with the common inlet (3) and the respective outlet valves (11) are in fluid communication with the common outlet (5) and wherein a centre of the outlet valve (11) for each pump cavity is positionable above a centre of the inlet valve (9) for the same pump cavity when the diaphragm pump is oriented for use to inhibit trapped gas; and a plurality of moveable diaphragms (13) each respectively provided in a respective of said pump cavities (7) for varying a volume of the pump cavities. The system further comprises a pump drive (31) which is configured to transfer a motion to the diaphragms (13) of the pump head (1; 101; 201) for accomplishing a fluid displacement from the common inlet (3) to the common outlet (5) of the pump head (1; 101; 201; 301) as a result of said varying of the volume of the pump cavities (7).

公开(公告)号：US20220025313A1

公开(公告)日：2022-01-27

申请号：US17296711

申请日：2019-12-10

Applicant: Cytiva Sweden AB

Inventor： Bjorn Olovsson ,  Andreas Lundin ,  Klaus Gebauer ,  Tim Francois ,  Kerstin Erickson

IPC: C12M1/00

Abstract: A flow distribution device for bioprocess systems, comprising: ⋅—a flow distribution manifold (12; 112; 212; 312) comprising: ⋅o at least four fluid connection tubes (14), wherein each fluid connection tube (14) comprises a first end (18) for fluid connection and an opposite second end (20) ⋅o a central common compartment (30; 130; 230; 330) to which the second ends (20) of each of the fluid connection tubes (14) are connected, whereby the first ends (18) of each of the fluid connection tubes (14) can be in fluid communication with the central common compartment (30; 130; 230; 330) ⋅—at least three pinching members (41) which are provided in connection with one fluid connection tube (14) of the flow distribution manifold (12; 112; 212; 312) each, wherein each of said pinching members (41) can be controlled into at least a first and a second position, wherein in the first position for each of the pinching members (41) the pinching member pinches one of the fluid connection tubes (14) such that fluid flow is prevented between the first end (18) and the second end (20) of this fluid connection tube (14)

公开(公告)号：US20220033750A1

公开(公告)日：2022-02-03

申请号：US17296726

申请日：2019-12-10

Applicant: Cytiva Sweden AB

Inventor： Andreas Lundin ,  Bjorn Olovsson ,  Klaus Gebauer ,  Tim Francois ,  Kerstin Erickson

IPC: C12M1/00 ,  C12M1/34

Abstract: A flow distribution device for bioprocess systems, comprising: a flow distribution manifold (12; 112) comprising: at least four fluid connection conduits (14), wherein each fluid connection conduit (14) comprises a first end (18) for fluid connection and an opposite second end (20), and wherein at least three of the fluid connection conduits comprise a membrane (19a) and a valve seat (19b), which membrane (19a) can be put in at least two different positions in relation to the valve seat (19b) for allowing or preventing fluid flow between the first end (18) and the second end (20) of the fluid connection conduit (14); and a central common compartment (30) to which the second ends (20) of each of the fluid connection conduits (14) are connected, whereby the first ends (18) of each of the fluid connection conduits (14) can be in fluid communication with the central common compartment (30) and wherein the fluid connection conduits (14) are entering the central common compartment (30) from at least three different directions; wherein said flow distribution device (10) further comprises at least three membrane actuation members (41) which are provided in connection with one membrane (19a) of the flow distribution manifold (12; 112) each, wherein each of said membrane actuation members (41) is configured for actuating the membrane (19a) to be in at least two different positions in relation to the valve seat (19b), wherein a first position of the membrane (19a) allows flow between the first end (18) and the second end (20) of the fluid connection conduit (14) and a second position of the membrane (19a) prevents flow between the first end (18) and the second end (20) of the fluid connection conduit (14).

公开(公告)号：US20240150697A1

公开(公告)日：2024-05-09

申请号：US18550075

申请日：2022-04-25

Applicant: CYTIVA SWEDEN AB

Inventor： Klaus Gebauer ,  Tim Francois ,  Andreas Lundin ,  Bjorn Markus Olovsson ,  Kerstin Erickson ,  Tomas Dalmo

IPC: C12M1/00 ,  C12M1/36 ,  C12M3/00

CPC classification number: C12M23/40 ,  C12M23/28 ,  C12M23/44 ,  C12M29/04 ,  C12M29/06 ,  C12M41/48

Abstract: The present invention relates to a reconfigurable bioprocessing system (80) operable to perform a predetermined set of bioprocessing operations therein. The reconfigurable bioprocessing system (80) comprises a base unit (60) comprising a plurality of valve actuators (102). At least one of the plurality of valve actuators (102) is operable to releasably engage with at least part of a pinch valve cassette (103, 203) to control fluid flow through the pinch valve cassette (103, 203). At least part of the pinch valve cassette (103, 203) is removably attachable to the base unit (60) and the pinch valve cassette (103, 203) is provided adjacent to said plurality of valve actuators (102). The reconfigurable bioprocessing system (80) also includes a control system operable to selectively actuate respective of said plurality of valve actuators (102) to provide a valve configuration within the pinch valve cassette (103, 203) to enable the base unit (60) and the pinch valve cassette (103, 203) together to perform one of the predetermined set of bioprocessing operations. A flow kit (107) for use in reconfigurable bioprocessing systems (80) and various methods (1000) for reconfiguring bioprocessing systems (80) (e.g. automatically) are also disclosed.

公开(公告)号：US20210162317A1

公开(公告)日：2021-06-03

申请号：US17268497

申请日：2019-08-20

Applicant: Cytiva Sweden AB

Inventor： Klaus Gebauer ,  Andreas Lundin ,  Fredrik Lundström

IPC: B01D15/18 ,  G01N30/20 ,  G01N30/38 ,  G01N30/46

Abstract: A connection device (1; 101) configured for connecting a separation system (3) with a separation device (5), wherein a fluid can be flowed from a separation system outlet connection (19), through a bypass fluid path (27) of the connection device to the separation system inlet connection (15) while a connected separation device (5) is by passed. For achieving this at least one of an inlet and an outlet valve (31, 33) provided in the connection device is provided in a closed state and at least one bypass valve (35, 35a, 35b) provided in the connection device is provided in an open state.

公开(公告)号：US20240182834A1

公开(公告)日：2024-06-06

申请号：US18553821

申请日：2022-04-25

Applicant: CYTIVA SWEDEN AB

Inventor： Andreas Lundin ,  Mats Rimmo

IPC: C12M1/00 ,  C12M1/34 ,  C12M1/36 ,  C12M3/00

CPC classification number: C12M29/04 ,  C12M23/40 ,  C12M23/42 ,  C12M23/44 ,  C12M41/30 ,  C12M41/48

Abstract: The present disclosure relates to a reconfigurable bioprocessing system (80) operable to perform a predetermined set of bioprocessing operations within the bioprocessing system (80), the bioprocessing system (80) comprising: a base unit (60) comprising a plurality of valve actuators, wherein at least one of the plurality of valve actuators is configured to releasably engage with a membrane valve cassette (200, 300, 400) that is removably attachable to the base unit (60), and wherein the at least one of the plurality of valve actuators is actuatable to regulate fluid flow through the membrane valve cassette (200, 300, 400); and a control system (20) operable to selectively actuate respective ones of the plurality of valve actuators to provide a valve configuration within the membrane valve cassette (200, 300, 400) to enable the base unit (60) and the membrane valve cassette (200, 300, 400) together to perform one of the predetermined set of bioprocessing operations.