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1.发明申请CONCATAMERIC LIGATION PRODUCTS: COMPOSITIONS METHODS AND KITS FOR SAME 审中-公开CONCATAMERIC LIGATION产品：组合物方法和用途相同公开(公告)号：US20120190019A1
公开(公告)日：2012-07-26
申请号：US13333302
申请日：2011-12-21
申请人： Caifu Chen , Kevin Hennessy , Kai Qin Lao , Teodoro Paner , Vinod Mirchandani
发明人： Caifu Chen , Kevin Hennessy , Kai Qin Lao , Teodoro Paner , Vinod Mirchandani
CPC分类号： C12Q1/6876 , C12Q1/6816 , C12Q2533/107 , C12Q2525/301
摘要： The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form a concatameric ligation product. In some embodiments of the present teachings, the concatameric ligation product can be amplified, and the identity and quantity of the target polynucleotides determined based on sequence introduced in the ligation reaction. Some embodiments of the present teachings provide methods for removing unligated probes from the reaction mixture. Some embodiments of the present teachings provide for highly multiplexed detection, identification, and quantification of a plurality of target polynucleotides using a variety of analytical procedures.
摘要翻译： 本教导涉及用于检测样品中的一种或多种靶多核苷酸序列的方法，组合物和试剂盒，以及用于形成连续连接产物的方法组合物和试剂盒。 在本教导的一些实施方案中，寡核苷酸与互补靶多核苷酸杂交并连接在一起以形成连接产物。 在本教导的一些实施方案中，可以扩增连续连接产物，并且基于在连接反应中引入的序列确定靶多核苷酸的身份和数量。 本教导的一些实施方案提供从反应混合物中除去未螯合的探针的方法。 本教导的一些实施方案使用各种分析程序提供多重检测，鉴定和定量多个靶多核苷酸。
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2.发明申请CONCATAMERIC LIGATION PRODUCTS: COMPOSITIONS METHODS AND KITS FOR SAME 审中-公开CONCATAMERIC LIGATION产品：组合物方法和用途相同公开(公告)号：US20100015631A1
公开(公告)日：2010-01-21
申请号：US12559476
申请日：2009-09-14
申请人： Caifu CHEN , Kevin Hennessy , Kai Qin Lao , Teodoro Paner , Vinod Mirchandani
发明人： Caifu CHEN , Kevin Hennessy , Kai Qin Lao , Teodoro Paner , Vinod Mirchandani
CPC分类号： C12Q1/6876 , C12Q1/6816 , C12Q2533/107 , C12Q2525/301
摘要： The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form a concatameric ligation product. In some embodiments of the present teachings, the concatameric ligation product can be amplified, and the identity and quantity of the target polynucleotides determined based on sequence introduced in the ligation reaction. Some embodiments of the present teachings provide methods for removing unligated probes from the reaction mixture. Some embodiments of the present teachings provide for highly multiplexed detection, identification, and quantification of a plurality of target polynucleotides using a variety of analytical procedures.
摘要翻译： 本教导涉及用于检测样品中的一种或多种靶多核苷酸序列的方法，组合物和试剂盒，以及用于形成连续连接产物的方法组合物和试剂盒。 在本教导的一些实施方案中，寡核苷酸与互补靶多核苷酸杂交并连接在一起以形成连接产物。 在本教导的一些实施方案中，可以扩增连续连接产物，并且基于在连接反应中引入的序列确定靶多核苷酸的身份和数量。 本教导的一些实施方案提供从反应混合物中除去未螯合的探针的方法。 本教导的一些实施方案使用各种分析程序提供多重检测，鉴定和定量多个靶多核苷酸。
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3.发明授权公开(公告)号：US07208278B2
公开(公告)日：2007-04-24
申请号：US10982619
申请日：2004-11-04
申请人： Caifu Chen , Kevin Hennessy , Kai Qin Lao , Teodoro Paner , Vinod Mirchandani
发明人： Caifu Chen , Kevin Hennessy , Kai Qin Lao , Teodoro Paner , Vinod Mirchandani
CPC分类号： C12P19/34 , C12Q1/6813 , C12Q1/6816 , C12Q2600/156 , C12Q2525/125 , C12Q2521/501 , C12Q2521/319 , C12Q2525/301 , C12Q2565/125 , C12Q2533/107
摘要： The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form a concatameric ligation product. In some embodiments of the present teachings, the concatameric ligation product can be amplified, and the identity and quantity of the target polynucleotides determined based on sequence introduced in the ligation reaction. Some embodiments of the present teachings provide methods for removing unligated probes from the reaction mixture. Some embodiments of the present teachings provide for highly multiplexed detection, identification, and quantification of a plurality of target polynucleotides using a variety of analytical procedures.
摘要翻译： 本教导涉及用于检测样品中的一种或多种靶多核苷酸序列的方法，组合物和试剂盒，以及用于形成连续连接产物的方法组合物和试剂盒。 在本教导的一些实施方案中，寡核苷酸与互补靶多核苷酸杂交并连接在一起以形成连接产物。 在本教导的一些实施方案中，可以扩增连续连接产物，并且基于在连接反应中引入的序列确定靶多核苷酸的身份和数量。 本教导的一些实施方案提供从反应混合物中除去未螯合的探针的方法。 本教导的一些实施方案使用各种分析程序提供多重检测，鉴定和定量多个靶多核苷酸。
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公开(公告)号：US20070259356A1
公开(公告)日：2007-11-08
申请号：US11609767
申请日：2006-12-12
申请人： Caifu Chen , Kevin Hennessy , Kai Lao , Teodoro Paner , Vinod Mirchandani
发明人： Caifu Chen , Kevin Hennessy , Kai Lao , Teodoro Paner , Vinod Mirchandani
CPC分类号： C12Q1/6876 , C12Q1/6816 , C12Q2533/107 , C12Q2525/301
摘要： The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form a concatameric ligation product. In some embodiments of the present teachings, the concatameric ligation product can be amplified, and the identity and quantity of the target polynucleotides determined based on sequence introduced in the ligation reaction. Some embodiments of the present teachings provide methods for removing unligated probes from the reaction mixture. Some embodiments of the present teachings provide for highly multiplexed detection, identification, and quantification of a plurality of target polynucleotides using a variety of analytical procedures.
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5.发明申请公开(公告)号：US20070099228A1
公开(公告)日：2007-05-03
申请号：US11609776
申请日：2006-12-12
申请人： Caifu Chen , Kevin Hennessy , Kai Lao , Teodoro Paner , Vinod Mirchandani
发明人： Caifu Chen , Kevin Hennessy , Kai Lao , Teodoro Paner , Vinod Mirchandani
CPC分类号： C12Q1/6876 , C12Q1/6816 , C12Q2533/107 , C12Q2525/301
摘要： The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form a concatameric ligation product. In some embodiments of the present teachings, the concatameric ligation product can be amplified, and the identity and quantity of the target polynucleotides determined based on sequence introduced in the ligation reaction. Some embodiments of the present teachings provide methods for removing unligated probes from the reaction mixture. Some embodiments of the present teachings provide for highly multiplexed detection, identification, and quantification of a plurality of target polynucleotides using a variety of analytical procedures.
摘要翻译： 本教导涉及用于检测样品中的一种或多种靶多核苷酸序列的方法，组合物和试剂盒，以及用于形成连续连接产物的方法组合物和试剂盒。 在本教导的一些实施方案中，寡核苷酸与互补靶多核苷酸杂交并连接在一起以形成连接产物。 在本教导的一些实施方案中，可以扩增连续连接产物，并且基于在连接反应中引入的序列确定靶多核苷酸的身份和数量。 本教导的一些实施方案提供从反应混合物中除去未螯合的探针的方法。 本教导的一些实施方案使用各种分析程序提供多重检测，鉴定和定量多个靶多核苷酸。
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6.发明申请公开(公告)号：US20060063163A1
公开(公告)日：2006-03-23
申请号：US10982619
申请日：2004-11-04
申请人： Caifu Chen , Kevin Hennessy , Kai Lao , Teodoro Paner , Vinod Mirchandani
发明人： Caifu Chen , Kevin Hennessy , Kai Lao , Teodoro Paner , Vinod Mirchandani
CPC分类号： C12P19/34 , C12Q1/6813 , C12Q1/6816 , C12Q2600/156 , C12Q2525/125 , C12Q2521/501 , C12Q2521/319 , C12Q2525/301 , C12Q2565/125 , C12Q2533/107
摘要： The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form a concatameric ligation product. In some embodiments of the present teachings, the concatameric ligation product can be amplified, and the identity and quantity of the target polynucleotides determined based on sequence introduced in the ligation reaction. Some embodiments of the present teachings provide methods for removing unligated probes from the reaction mixture. Some embodiments of the present teachings provide for highly multiplexed detection, identification, and quantification of a plurality of target polynucleotides using a variety of analytical procedures.
摘要翻译： 本教导涉及用于检测样品中的一种或多种靶多核苷酸序列的方法，组合物和试剂盒，以及用于形成连续连接产物的方法组合物和试剂盒。 在本教导的一些实施方案中，寡核苷酸与互补靶多核苷酸杂交并连接在一起以形成连接产物。 在本教导的一些实施方案中，可以扩增连续连接产物，并且基于在连接反应中引入的序列确定靶多核苷酸的身份和数量。 本教导的一些实施方案提供从反应混合物中除去未螯合的探针的方法。 本教导的一些实施方案使用各种分析程序提供多重检测，鉴定和定量多个靶多核苷酸。
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公开(公告)号：US09641123B2
公开(公告)日：2017-05-02
申请号：US13421740
申请日：2012-03-15
申请人： Anders Swahn , Neil Morris , Kevin Hennessy , Thomas Peter Hunt , Paul Adriani
发明人： Anders Swahn , Neil Morris , Kevin Hennessy , Thomas Peter Hunt , Paul Adriani
CPC分类号： H02S20/30 , F24S25/11 , F24S25/632 , F24S2025/012 , F24S2025/014 , F24S2025/6007 , F24S2025/601 , F24S2030/17 , F24S2080/012 , F24S2080/015 , H02S20/00 , Y02E10/47 , Y02E10/50 , Y10T29/49959 , Y10T29/49966
摘要： System and method for mounting one or more photovoltaic modules includes one or more flexible rods, including a first end and a second end opposite the first end, each of the one or more flexible rods further including an inner core and a first jacket surrounding the inner core between the first end and the second end. The first end is configured to be attached to at least one photovoltaic module using one or more first adhesive materials. The second end is configured to be inserted into at least one hole of a modular rail and attached to at least the modular rail using one or more second adhesive materials. The one or more flexible rods are configured to allow at least a lateral movement in a first direction between the photovoltaic module and the modular rail and support at least the photovoltaic module in a second direction.
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公开(公告)号：US20080003604A1
公开(公告)日：2008-01-03
申请号：US11743517
申请日：2007-05-02
申请人： David Ruff , Mark Shannon , Kenneth Livak , Karl Guegler , Kevin Hennessy
发明人： David Ruff , Mark Shannon , Kenneth Livak , Karl Guegler , Kevin Hennessy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C07K14/47 , C07K14/4711 , C12Q1/6816 , C12Q2533/107
摘要： The present teachings provide methods, compositions, and kits for detecting the presence of protein aggregates. In some embodiments, the protein aggregate is treated with a labeled precursor, and the labeled precursor is incorporated into the protein aggregate to form a labeled protein aggregate. The labeled protein aggregate is then measured, thus detecting the presence of the protein aggregate. In some embodiments, the labeled protein aggregate is detected by interaction of labeled precursors, for example by a proximity ligation assay.
摘要翻译： 本教导提供了用于检测蛋白质聚集体的存在的方法，组合物和试剂盒。 在一些实施方案中，用标记的前体处理蛋白质聚集体，并将标记的前体掺入蛋白质聚集体中以形成标记的蛋白质聚集体。 然后测量标记的蛋白质聚集体，从而检测蛋白质聚集体的存在。 在一些实施方案中，标记的蛋白质聚集体通过标记的前体的相互作用来检测，例如通过邻近连接测定。
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公开(公告)号：US20070281367A1
公开(公告)日：2007-12-06
申请号：US11743052
申请日：2007-05-01
申请人： Kevin Hennessy , Jeffrey Rice
发明人： Kevin Hennessy , Jeffrey Rice
IPC分类号： G01N33/566 , C07H21/00 , C12N9/00
CPC分类号： C12Q1/6876 , C07K14/47 , C07K14/4711 , C12Q1/6816 , C12Q2533/107
摘要： The present teachings provide methods, compositions, and kits for quantitating antibodies. In some embodiments, the method comprises binding two proximity probes to two binding sites on the target antibody, wherein the proximity probes are comprised of a binding moiety and a thereto coupled oligonucleotide, wherein the binding moities of each proximity probe are the same, and wherein the binding sites for the binding moieties of the proximity probes are on one and the same target antibody. The binding moieties are allowed to bind to the target antibody and the oligonucleotides interact with each other if they are in close proximity to each other. Quantitating the degree of interaction between the oligonucleotides allows for quantitation of the target antibody.
摘要翻译： 本教导提供了用于定量抗体的方法，组合物和试剂盒。 在一些实施方案中，所述方法包括将两个邻近探针结合到靶抗体上的两个结合位点，其中所述接近探针由结合部分和其耦合的寡核苷酸组成，其中每个邻近探针的结合度相同，并且其中 接近探针的结合部分的结合位点在同一个靶抗体上。 允许结合部分与靶抗体结合，并且如果寡核苷酸彼此接近，则寡核苷酸彼此相互作用。 量化寡核苷酸之间的相互作用程度允许定量靶抗体。
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公开(公告)号：US20050271553A1
公开(公告)日：2005-12-08
申请号：US11021039
申请日：2004-12-21
申请人： Paul Ramstad , Michael Harrold , Kevin Hennessy , Aldrich Lau
发明人： Paul Ramstad , Michael Harrold , Kevin Hennessy , Aldrich Lau
CPC分类号： B01L3/50853 , B01J20/3293 , B01J47/016 , B01L2200/0631 , B01L2300/046 , B01L2300/0829
摘要： Devices are provided which include supports upon which one or more ion-exchange materials can be disposed for purifying a sample. In various embodiments, the supports include a plurality of deformable members, for example, petal-shaped purification members, that provide binding sites for ion-exchange material and optionally biochemical species, chemicals, salts, or other materials. An apparatus and method are also provided for the insertion and removal of the purification members into respective wells of a multi-well microplate.
摘要翻译： 提供了包括可以设置一种或多种离子交换材料用于纯化样品的载体的装置。 在各种实施例中，支撑件包括多个可变形构件，例如花瓣形净化构件，其提供用于离子交换材料和任选的生化物质，化学物质，盐或其它材料的结合位点。 还提供了一种用于将净化构件插入和移除到多孔微板的相应孔中的装置和方法。
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